Journal
SOUTH AFRICAN JOURNAL OF BOTANY
Volume 151, Issue -, Pages 614-627Publisher
ELSEVIER
DOI: 10.1016/j.sajb.2022.10.029
Keywords
Essential oil from Prunella vulgaris L; Chemical component; Anti-bacterial potency; Anti-inflammatory activity; Immunoregulatory effect
Categories
Funding
- National Key R&D Program of China
- Natural Science Foundation of Hunan Province
- First-class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine
- Hunan Health Commission
- Science and Tech-nology Project of Changsha
- [2017YFC1701900]
- [2021JJ40551]
- [2022JJ50008]
- [201803]
- [B202313057639]
- [kq2004054]
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The study demonstrated the favorable antibacterial, anti-inflammatory, and immunoregulatory effects of essential oil from Prunella vulgaris L., providing a reference for its application as food or drug.
Our preliminary results suggested a favorable therapeutical effect of essential oil from Prunella vulgaris L. (PVO) on pelvic inflammation. In this study, we further analyzed the chemical components of PVO through gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS), and its anti-bacterial, anti-inflammatory, and immunoregulatory properties. Fifty-six chemical com-ponents were identified with GC-MS, most of which were fatty acids. The positive and negative ion modes of LC-MS were used to detect 48 and 37 compounds with content above 0.1%, respectively, most of which were terpenoids and lipids. The anti-bacterial experiment revealed that PVO could strongly inhibit both gram -neg-ative and gram-positive bacteria. It had a significant inhibiting effect on influenza virus neuraminidase, with an inhibition ratio of over 50%. Besides, PVO dramatically inhibited the NO release and the levels of IL-6 in RAW264.7 cells induced by LPS. Moreover, immunological results indicated that PVO could synergistically facilitate concanavalin A (ConA) to stimulate the secretion of Th1 and Th2 cytokines from the splenic lym-phocytes of mice but also regulate the Th1/Th2 balance to exert dual immunoregulatory effects. Generally, these results proved the anti-bacterial, anti-inflammatory, and immunoregulatory effects of PVO, thus pro-viding a reference for the application of PVO as a food or drug.(c) 2022 Published by Elsevier B.V. on behalf of SAAB.
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