4.3 Article

Intermittent hypoxia BMSCs-derived exosomal miR-31-5p promotes lung adenocarcinoma development via WDR5-induced epithelial mesenchymal transition

Related references

Note: Only part of the references are listed.
Article Cell & Tissue Engineering

Human bone marrow mesenchymal stem cell-derived exosomes containing microRNA-425 promote migration, invasion and lung metastasis by down-regulating CPEB1

Guoqiang Wang et al.

Summary: This study found that BMSC-Exos could inhibit CPEB1 expression in lung cancer cells by delivering miR-425, promoting the malignant biological properties of lung cancer cells and their metastasis.

REGENERATIVE THERAPY (2022)

Article Medicine, Research & Experimental

WDR5 promotes the proliferation of lung adenocarcinoma by inducing SOX9 expression

Aihua Ji et al.

Summary: The study demonstrates the important roles of WDR5 and SOX9 in lung adenocarcinoma, both serving as prognostic biomarkers predicting poor outcomes. WDR5 could promote proliferation of lung adenocarcinoma by upregulating SOX9 expression.

BIOMARKERS IN MEDICINE (2021)

Article Cell Biology

Hypoxic bone marrow mesenchymal cell-extracellular vesicles containing miR-328-3p promote lung cancer progression via the NF2-mediated Hippo axis

Xi Liu et al.

Summary: The study demonstrated that EVs derived from hypoxic bone marrow mesenchymal cells can deliver miR-328-3p to lung cancer cells, promoting cancer cell proliferation, invasion, and migration by targeting the NF2 gene to inhibit the Hippo pathway. This ultimately leads to the occurrence and progression of lung cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Oncology

ESM1/HIF-1α pathway modulates chronic intermittent hypoxia-induced non-small-cell lung cancer proliferation, stemness and epithelial-mesenchymal transition

Xin Gu et al.

Summary: Obstructive sleep apnea (OSA) leads to chronic intermittent hypoxia (CIH) which promotes progression of non-small cell lung cancer (NSCLC) through the ESM1/HIF-1α pathway, enhancing lung cancer stem cell (LCSC) stemness, drug resistance, cell proliferation, migration, and invasion. Inhibition of ESM1 reverses the negative effects of CIH on LCSCs, suggesting ESM1 as a crucial mediator of CIH-induced lung cancer progression.

ONCOLOGY REPORTS (2021)

Article Biotechnology & Applied Microbiology

WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways

Tianli Chen et al.

Summary: This study demonstrates that WDR5 interacts with c-Myc in cholangiocarcinoma (CCA), leading to increased HIF-1 alpha expression and stability, thereby promoting tumor metastasis and invasion.

MOLECULAR THERAPY (2021)

Article Oncology

Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling

Fengqiang Yu et al.

Summary: Exosomal miR-31-5p derived from hypoxic LUAD cells plays a crucial role in promoting tumor progression by targeting specific genes and signaling pathways. Higher levels of circulating exosomal miR-31-5p were detected in LUAD patients, particularly those with metastatic disease, suggesting its potential as a diagnostic biomarker for LUAD.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Identification of key microRNAs and hub genes in non-small-cell lung cancer using integrative bioinformatics and functional analyses

Feifeng Song et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

Xina Zhang et al.

MOLECULAR CANCER (2019)

Article Medicine, Research & Experimental

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9

Dong-Mei Wu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Cell Biology

LncRNA DGCR5 promotes lung adenocarcinoma (LUAD) progression via inhibiting hsa-mir-22-3p

Hui-Xing Dong et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Intermittent hypoxia induces a metastatic phenotype in breast cancer

Anna Chen et al.

ONCOGENE (2018)

Review Cell Biology

Cell death-based treatment of lung adenocarcinoma

Tatiana V. Denisenko et al.

CELL DEATH & DISEASE (2018)

Article Cell Biology

Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7

Hao Wu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

Gastric cancer-derived exosomes promote peritoneal metastasis by destroying the mesothelial barrier

Guang Deng et al.

FEBS LETTERS (2017)

Review Biochemistry & Molecular Biology

Exosomes: From Garbage Bins to Promising Therapeutic Targets

Mohammed H. Rashed et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Oncology

New insights into the role of EMT in tumor immune escape

Stephane Terry et al.

MOLECULAR ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

CSN5 promotes renal cell carcinoma metastasis and EMT by inhibiting ZEB1 degradation

Shouhua Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Medicine, Research & Experimental

MicroRNA-31 initiates lung turnorigenesis and promotes mutant KRAS-driven lung cancer

Mick D. Edmonds et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Biochemistry & Molecular Biology

Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells

Katrin Gutsche et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Oncology

Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro

Zhen Qu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)

Review Oncology

The MYC-WDR5 Nexus and Cancer

Lance R. Thomas et al.

CANCER RESEARCH (2015)

Review Oncology

Signaling by exosomal microRNAs in cancer

Germana Falcone et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2015)

Article Clinical Neurology

Obstructive sleep apnea is associated with cancer mortality in younger patients

Miguel A. Martinez-Garcia et al.

SLEEP MEDICINE (2014)

Article Critical Care Medicine

Association between Obstructive Sleep Apnea and Cancer Incidence in a Large Multicenter Spanish Cohort

Francisco Campos-Rodriguez et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Biotechnology & Applied Microbiology

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Shin-ichiro Ohno et al.

MOLECULAR THERAPY (2013)

Article Physiology

Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea

Isaac Almendros et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2013)

Editorial Material Clinical Neurology

Here Come the Sleep Apnea-Cancer Studies

Paul E. Peppard et al.

SLEEP (2013)

Review Oncology

Regulatory networks defining EMT during cancer initiation and progression

Bram De Craene et al.

NATURE REVIEWS CANCER (2013)

Article Critical Care Medicine

Sleep-disordered Breathing and Cancer Mortality Results from the Wisconsin Sleep Cohort Study

F. Javier Nieto et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Letter Respiratory System

Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoea

I. Almendros et al.

EUROPEAN RESPIRATORY JOURNAL (2012)

Review Oncology

Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links

Christina Scheel et al.

SEMINARS IN CANCER BIOLOGY (2012)

Article Multidisciplinary Sciences

Isolation and Characterization of RNA-Containing Exosomes

Cecilia Lasser et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2012)

Article Biochemistry & Molecular Biology

Effect of Chronic Intermittent Hypoxia on Biological Behavior and Hypoxia-Associated Gene Expression in Lung Cancer Cells

Yonglei Liu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2010)

Review Medicine, General & Internal

Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship

Julian R. Molina et al.

MAYO CLINIC PROCEEDINGS (2008)