Update on recent developments in imaging of inflammation in osteoarthritis: a narrative review

Article Radiology, Nuclear Medicine & Medical Imaging

Impact of Sustained Synovitis on Knee Joint Structural Degeneration: 4-Year MRI Data from the Osteoarthritis Initiative

Sara Ramezanpour et al.

Summary: This study investigates the impact of sustained synovitis on the progression of knee degenerative changes. The results suggest that sustained synovitis is associated with greater progression of structural degenerative disease.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2023)

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Article Orthopedics

Infrapatellar fat pad volume and Hoffa-synovitis after ACL reconstruction: Association with early osteoarthritis features and pain over 5 years

Harvi F. Hart et al.

Summary: The study found no significant differences between participants 1-year post-ACLR and uninjured controls. Greater IPFP volume and Hoffa-synovitis may be associated with the presence and worsening of some early OA features in those post-ACLR, but not with pain.

JOURNAL OF ORTHOPAEDIC RESEARCH (2022)

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Article Rheumatology

Novel Framework for Measuring Whole Knee Osteoarthritis Progression Using Magnetic Resonance Imaging

Jeffrey B. Driban et al.

Summary: In this study, a set of composite scores combining measurements of hyaline cartilage damage, BMLs, and effusion-synovitis based on MRI were developed and validated. By evaluating the ability and sensitivity of these composite scores in knee osteoarthritis progression, two composite scores emerged that reflected cumulative damage and dynamic disease activity. These findings are important for understanding the progression of knee osteoarthritis.

ARTHRITIS CARE & RESEARCH (2022)

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Article Rheumatology

Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

David J. Hunter et al.

Summary: This study identifies the optimal combination of imaging and biochemical biomarkers for predicting knee osteoarthritis progression. These biomarkers have the potential to be used in future disease-modifying trials to select participants likely to experience progression of knee OA.

ARTHRITIS CARE & RESEARCH (2022)

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Review Orthopedics

Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review

P. Dainese et al.

Summary: This article systematically reviews the relationship between markers of inflammation and pain in patients with knee osteoarthritis. The study found a moderate correlation between inflammation and pain, but the quality of evidence was conflicting.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Article Rheumatology

Presence of Magnetic Resonance Imaging-Defined Inflammation Particularly in Overweight and Obese Women Increases Risk of Radiographic Knee Osteoarthritis: The POMA Study

Frank W. Roemer et al.

Summary: Overweight and obese women have increased odds for developing radiographic OA, especially in the presence of inflammatory markers.

ARTHRITIS CARE & RESEARCH (2022)

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Article Rheumatology

Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis

Erin M. Macri et al.

Summary: This study aimed to evaluate the association between patellofemoral and tibiofemoral osteoarthritis (OA) features and localized anterior knee pain (AKP), and found that patellofemoral joint OA features and inflammation were associated with AKP.

ARTHRITIS CARE & RESEARCH (2022)

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Article Biophysics

Gadolinium-free assessment of synovitis using diffusion tensor imaging

Halston J. C. Sandford et al.

Summary: In this study, DTI was found to quantify the intensity of synovitis in knees with osteoarthritis without the use of exogenous contrast agent, providing additional assessment information on the severity of arthritis. Comparisons between DTI and DCE-MRI measures with semi-quantitative grading systems showed that quantitative measures of synovitis intensity may offer valuable insights for evaluating OA severity.

NMR IN BIOMEDICINE (2022)

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Article Multidisciplinary Sciences

Automatic estimation of knee effusion from limited MRI data

Sandhya Raman et al.

Summary: The study investigates the accuracy of a neural network in classifying knee effusion from low-resolution MRI images, showing similar performance to a human radiologist and suggesting potential as an assessment tool.

SCIENTIFIC REPORTS (2022)

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Article Medicine, General & Internal

Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial

Zoe Paskins et al.

Summary: This study compared the clinical effectiveness of adding ultrasound guided intra-articular hip injection of corticosteroid and local anaesthetic to advice and education in adults with hip osteoarthritis. The results showed that this treatment option can improve hip pain intensity, especially for patients with synovitis or effusion.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Article Orthopedics

Synovitis mediates the association between bone marrow lesions and knee pain in osteoarthritis: data from the Foundation for the National Institute of Health (FNIH) Osteoarthritis Biomarkers Consortium

X. Wang et al.

Summary: Subchondral bone marrow lesions (BMLs) and synovitis are important sources of pain in knee osteoarthritis (KOA), and this study found that synovitis partially mediates the relationship between BMLs and knee pain.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Article Orthopedics

Effusion-synovitis worsening mediates the association between body mass index and Kellgren-Lawrence progression in obese individuals: data from the Osteoarthritis Initiative

M. Banuls-Mirete et al.

Summary: This study investigated the relationship between body mass index (BMI), synovitis, and knee osteoarthritis (KOA) progression. The results showed that worsening effusion-synovitis mediated the association between BMI and KOA progression and was associated with increased risk of KOA progression, particularly among obese individuals.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Article Medicine, Research & Experimental

Study protocol for a randomised controlled trial of diacerein versus placebo to treat knee osteoarthritis with effusion-synovitis (DICKENS)

Guoqi Cai et al.

Summary: This study aims to evaluate the effectiveness of diacerein in knee osteoarthritis patients with effusion-synovitis, and provide high-quality evidence. The results may have significant benefits for patients with an inflammatory phenotype.

TRIALS (2022)

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Article Rheumatology

Metabolomics with severity of radiographic knee osteoarthritis and early phase synovitis in middle-aged women from the Iwaki Health Promotion Project: a cross-sectional study

Eiji Sasaki et al.

Summary: This study investigated the key plasma metabolites and metabolic pathways associated with radiographic osteoarthritis (OA) severity and synovitis. Large sample metabolome analysis revealed that cystine may be a potential metabolic biomarker for radiographic osteoarthritis and early phase synovitis.

ARTHRITIS RESEARCH & THERAPY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Contrast-enhanced CT techniques and MRI perform equally well in arthritis imaging of the hand: a prospective diagnostic accuracy study

Sevtap Tugce Ulas et al.

Summary: This study compared the performance of dual-energy CT and CT subtraction in detecting arthritis, with CT-S having the highest diagnostic accuracy. Both iMap and MRI showed good correlation and interreader reliability. Musculoskeletal ultrasound remains the most available modality for arthritis imaging and served as the gold standard in this study.

EUROPEAN RADIOLOGY (2022)

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Article Rheumatology

Effusion attenuates the effect of synovitis on radiographic progression in patients with hand osteoarthritis: a longitudinal magnetic resonance imaging study

W. Damman et al.

Summary: The study found that effusion in hand osteoarthritis patients is not associated with pain or radiographic progression. However, the association between other known risk factors and pain and progression is stronger in the absence of effusion.

CLINICAL RHEUMATOLOGY (2021)

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Article Orthopedics

Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative

Thanat Kanthawang et al.

Summary: Being overweight or obese was significantly associated with a greater prevalence and severity of synovial inflammation imaging biomarkers. The synovial inflammation imaging biomarkers showed positive associations with average T(2) values, WORMS maximum scores, and total WOMAC pain scores. The kappa values for imaging biomarkers showed high reproducibility among readers.

SKELETAL RADIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study

James W. MacKay et al.

Summary: K-trans demonstrated the best test-retest repeatability, discrimination between OA and HV, and responsiveness compared to IAUC(60) and VEP. Biomarkers derived from semiautomatic segmentation outperformed those derived from manual segmentation in all aspects. These findings suggest that K-trans is the optimal DCE-MRI biomarker for use in experimental medicine studies.

EUROPEAN RADIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Non-contrast MRI of synovitis in the knee using quantitative DESS

Jacob Thoenen et al.

Summary: The study demonstrates that qDESS has the potential to be an alternative MRI technique for assessing the severity of synovitis in the knee, with good consistency and diagnostic confidence.

EUROPEAN RADIOLOGY (2021)

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Article Orthopedics

[18F]NaF PET-MRI provides direct in-vivo evidence of the association between bone metabolic activity and adjacent synovitis in knee osteoarthritis: a cross-sectional study

J. W. MacKay et al.

Summary: The study demonstrated that synovitis was more intense adjacent to peripheral bone regions with increased metabolic activity, and bone metabolic activity was positively associated with the intensity of adjacent synovitis.

OSTEOARTHRITIS AND CARTILAGE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Feasibility of dual-phase 99mTc-MDP SPECT/CT imaging in rheumatoid arthritis evaluation

Yasser G. Abdelhafez et al.

Summary: This study demonstrates the feasibility of dual-phase SPECT/CT scanning in assessing small joints of RA patients, with reliable quantitative and qualitative measures obtained from the images. The findings suggest that SPECT/CT may offer a unique approach for evaluating synovitis and osseous involvement in RA joints.

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY (2021)

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Article Rheumatology

Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI

Bas A. de Vries et al.

Summary: The study found that qDESS MRI is able to detect synovitis in patients with knee OA, but with some underestimation. For detecting mild synovitis or higher, qDESS showed high sensitivity and specificity.

ARTHRITIS RESEARCH & THERAPY (2021)

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Article Rheumatology