☆ 4.7 Article

Self-propelled quantum dots-based spherical nucleic amplifier for ratiometric imaging of intracellular microRNAs

SENSORS AND ACTUATORS B-CHEMICAL (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Analytical

Framework Nucleic Acid-Based Spatial-Confinement Amplifier for miRNA Imaging in Living Cells

Yinghui Feng et al.

Summary: In this study, a framework nucleic acid (FNA)-based nonenzymatic spatial-confinement amplifier was developed for rapid and reliable intracellular miRNA imaging. By encapsulating the localized catalytic hairpin assembly (L-CHA) reactor in the inner cavity of the FNA and utilizing the spatial-confinement effect, the reaction rate was accelerated and the dynamic performance was improved.

ANALYTICAL CHEMISTRY (2022)

Add to Collection

Article Chemistry, Analytical

Synthesis of quantum dot encoded multicolour nanobeads for the ultrasensitive and multiplex immunochromatographic detection of neonicotinoid insecticides

Hui Cao et al.

Summary: A novel fluorescent immunochromatographic assay strip based on quantum dot encoded multicolour nanobead was developed for simultaneous detection of three neonicotinoid insecticides in vegetable samples. This QB-ICA approach demonstrated higher sensitivity and stability, making it a potential choice for multiplex detection in agricultural products.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Add to Collection

Article Chemistry, Analytical

Calcium-Differentiated Cellular Internalization of Allosteric Framework Nucleic Acids for Targeted Payload Delivery

Jiao Zheng et al.

Summary: This study presents a novel target delivery system that utilizes the 2D-to-3D transformation of nucleic acid nano vehicles to enhance cellular internalization and enable live-cell mRNA imaging. This system holds potential for precise disease treatment.

ANALYTICAL CHEMISTRY (2022)

Add to Collection

Article Chemistry, Analytical

Freezing-assisted nano-sweeping of short oligonucleotides using spherical nucleic acids: A fluorometric platform for quantification of microRNAs

Abbas Karami et al.

Summary: This study presents a new biosensing platform called nano-sweeping for quantitative detection of miRNA-30a. The method utilizes gold nanoparticle-core spherical nucleic acid hybridization and gravitational separation to achieve rapid and accurate quantification of miRNA-30a. The approach is fluorophore independent, allowing for attachment of any fluorescent dye, and has a linear response within a concentration range of 0-3.55 ng/μL.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Add to Collection

Article Chemistry, Analytical

Dual-channel fluorescent imaging of reactive oxygen species in living cells based on Ce(III) modified quantum dots with oxidation triggered phosphatase-like activity

Weilin Mao et al.

Summary: The two-wavelength fluorescent sensing and imaging of reactive oxygen species (ROS) was demonstrated using Ce(III) ions modified fluorescent quantum dots (QDs). Ce(IV)/QDs can catalyze the hydrolysis of 4-MUP to generate blue emission, while ROS has only slight effect on the red fluorescent signal of QDs. The successful ratiometric fluorescent detection of ROS and dual-channel fluorescent ROS imaging in cells were achieved.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Add to Collection

Article Biophysics

Fuel strand-powered self-propelled electrochemical DNA machine for enzyme-free and distinctly amplified detection of nucleic acid with tunable performance

Zhen Zhao et al.

Summary: A self-propelled DNA machine for enzyme-free and ultrasensitive electrochemical detection of nucleic acid was developed using a new strategy of fuel strand-powered target recycling and successive proximity-based inter-strand displacement. The system showed tunable detection performance and achieved a low detection limit of 0.1 fM, making it a powerful tool for amplified detection of nucleic acid with potential applications in bioanalysis, disease diagnosis, and biomedicine.

BIOSENSORS & BIOELECTRONICS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Flash Synthesis of Spherical Nucleic Acids with Record DNA Density

Yan Hao et al.

Summary: By using a rapid dehydration method, the synthesis of spherical nucleic acids with record-high DNA density is achieved in seconds, resulting in a 3-time increase in DNA density compared to traditional methods. This ultra-high density DNA grafting facilitates the formation of core-satellite assemblies, making the synthesis of spherical nucleic acids easier and enabling future explorations of the physical, chemical, and biological effects of high-density DNA spherical nucleic acids.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection

Article Chemistry, Analytical

Multiplexed detection of bladder cancer microRNAs based on core-shell-shell magnetic quantum dot microbeads and cascade signal amplification

Junwen Xu et al.

Summary: This study presented a microscopic imaging method for multiplexed detecting BC miRNAs using core-shell-shell bifunctional MFBs, incorporating CHA and TdT-mediated DNA polymerization. The strategy achieved sensitive and precise detection of miRNAs in clinical serum specimens, demonstrating consistency with qRT-PCR.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Add to Collection

Article Chemistry, Analytical

A near-infrared ratiometric fluorescent probe for selectively tracking human cytochrome P450 3A5 in living cells and tumor-bearing mice

Hefang Ji et al.

Summary: Two novel enzyme-activatable near-infrared ratiometric fluorescent probes, Hcy-Br and Hcy-Cl, were designed and synthesized to measure the activity of CYP3A5 in complex biological systems. These probes were successfully used to monitor endogenous CYP3A5 activity in living cells and tumor-bearing mice, representing a potential tool for investigating the function of CYP3A5 in drug metabolism and pathologic processes.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Many Birds, One Stone: A Smart Nanodevice for Ratiometric Dual-Spectrum Assay of Intracellular MicroRNA and Multimodal Synergetic Cancer Therapy

Peng He et al.

Summary: The study presented an integrated smart nanodevice composed of Au@Cu2-xS@polydopamine nanoparticles and fuel DNA-conjugated tetrahedral DNA nanostructures for antitumor therapy and miRNA detection. Utilizing a SERS-FL dual-spectrum biosensor, the device achieved high detection sensitivity and low background signal for improved accuracy in diagnosing cancer cell miRNA.

ACS NANO (2021)

Add to Collection

Article Nanoscience & Nanotechnology

A One-Two-Three Multifunctional System for Enhanced Imaging and Detection of Intracellular MicroRNA and Chemogene Therapy

Xun Liu et al.

Summary: The study introduces a novel "one-two-three" system for enhanced imaging and detection of miRNA-21 in cancer cells, as well as chemogene therapy. The system features a miR-21-triggered endogenous substance-accelerated cyclic reaction, two signal switch modes, and three functions including enhanced imaging, detection, and comprehensive treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Framework nucleic acid programmed combinatorial delivery nanocarriers for parallel and multiplexed analysis

Yinghui Feng et al.

Summary: In this study, a nucleic acid programmed strategy was used to develop nanocarriers that can precisely package multiple cargos, allowing for multiplexed analysis and comparison between normal individuals and patients with prostate enlargement. Additionally, the nanocarriers were also able to image and distinguish between different cancer cells and normal cells.

CHEMICAL COMMUNICATIONS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Multicolor fluorescence encoding of different microRNAs in lung cancer tissues at the single-molecule level

Chen-chen Li et al.

Summary: The integration of multicolor fluorophore-encoded cascade signal amplification with single-molecule detection facilitates simultaneous measurement of different miRNAs in lung cancer tissues, demonstrating high sensitivity, good selectivity, and the capability of multiplexed assay. The method accurately quantifies miR-155 and miR-21, distinguishing their expression between non-small cell lung cancer patients and healthy individuals, validated by quantitative reverse transcription polymerase chain reaction.

CHEMICAL SCIENCE (2021)

Add to Collection

Article Chemistry, Analytical

A Spherical Nucleic Acid Probe Based on the Au-Se Bond

Peng Gao et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection

Article Chemistry, Analytical

Three-Dimensional DNA Nanomachine Biosensor by Integrating DNA Walker and Rolling Machine Cascade Amplification for Ultrasensitive Detection of Cancer-Related Gene

Na Wu et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Amplified FRET Nanoflares: An Endogenous mRNA-Powered Nanomachine for Intracellular MicroRNA Imaging

Jing Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection

Article Chemistry, Analytical

Construction of an Exonuclease III-Propelled Integrated DNAzyme Amplifier for Highly Efficient microRNA Detection and Intracellular Imaging with Ultralow Background

Yangjie Zhou et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Principles and Applications of Nucleic Acid Strand Displacement Reactions

Friedrich C. Simmel et al.

CHEMICAL REVIEWS (2019)

Add to Collection

Review Engineering, Biomedical

Quantum dots in biomedical applications

Angela M. Wagner et al.

ACTA BIOMATERIALIA (2019)

Add to Collection

Article Chemistry, Analytical

Erythrocyte membrane-biointerfaced spherical nucleic acids: Robust performance for microRNA quantification

Yi Yang et al.

ANALYTICA CHIMICA ACTA (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Catalytic Self-Assembly of Quantum-Dot-Based MicroRNA Nanosensor Directed by Toehold-Mediated Strand Displacement Cascade

Fei Ma et al.

NANO LETTERS (2019)

Add to Collection

Article Chemistry, Analytical

A Ratiometric Fluorescent Bioprobe Based on Carbon Dots and Acridone Derivate for Signal Amplification Detection Exosomal microRNA

Yaokun Xia et al.

ANALYTICAL CHEMISTRY (2018)

Add to Collection

Article Chemistry, Analytical

Label-free detection of microRNA based on the fluorescence quenching of silicon nanoparticles induced by catalyzed hairpin assembly coupled with hybridization chain reaction

Longhua Ding et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Add to Collection

Article Chemistry, Analytical

Luminescent quantum dots for miRNA detection

O. A. Goryacheva et al.

TALANTA (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Multiplex microRNA imaging in living cells using DNA-capped-Au assembled hydrogels

Xiangdan Meng et al.

CHEMICAL SCIENCE (2018)

Add to Collection

Article Multidisciplinary Sciences

A microRNA-initiated DNAzyme motor operating in living cells

Hanyong Peng et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Chemistry, Multidisciplinary

The development of nanostructure assisted isothermal amplification in biosensors

Ruixue Duan et al.

CHEMICAL SOCIETY REVIEWS (2016)

Add to Collection

Article Materials Science, Multidisciplinary

Binding of Streptavidin to Surface-attached Biotin with Different Spacer Thicknesses

Li Yifei et al.

JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Spherical Nucleic Acids

Joshua I. Cutler et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Add to Collection

Article Chemistry, Multidisciplinary

Efficient protein-ligand interaction by guaranteeing mesospacing between immobilized biotins

YS Choi et al.

CHEMICAL COMMUNICATIONS (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.