Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 72, Issue 2, Pages 551-557Publisher
HUMANA PRESS INC
DOI: 10.1007/s12013-014-0501-8
Keywords
Mir-145 mimic; Suntinib; GBM
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Although aggressive therapeutic regimen has been applied in the treatment of Glioblastoma (GBM), the prognosis of patients with GBM remains poor. Preclinical studies have demonstrated the efficacy of Suntinib in GBM both in vitro and in vivo. In this study, we showed that the cytotoxicity was enhanced by transfection with miR-145 mimic. In addition, we suggested that the enhanced cytotoxicity of Sunitinib by miR-145 mimic was mediated by inhibition of both P-gp and Bcrp.
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