Related references
Note: Only part of the references are listed.Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review
Sajad Fakhri et al.
SEMINARS IN CANCER BIOLOGY (2022)
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
Shogo Kumagai et al.
CANCER CELL (2022)
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Adele M. Nicolas et al.
CANCER CELL (2022)
The hallmarks of cancer metabolism: Still emerging
Natalya N. Pavlova et al.
CELL METABOLISM (2022)
In Vivo Anticancer Activity of AZD3965: A Systematic Review
Ana Silva et al.
MOLECULES (2022)
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease
Jingyi Li et al.
NEUROBIOLOGY OF DISEASE (2022)
Cancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures
Bing Feng et al.
CANCER CELL INTERNATIONAL (2022)
Editorial: Metabolite and Nutrient Transporters in Cancer-Cell Metabolism: Role in Cancer Progression and Metastasis
Vadivel Ganapathy et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics
Dolly Sharma et al.
SEMINARS IN CANCER BIOLOGY (2022)
Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification
Chloe Buyse et al.
METABOLITES (2022)
Metabolic Reprogramming in Tumor Endothelial Cells
Melissa Garcia-Caballero et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Lactate increases stemness of CD8+T cells to augment anti-tumor immunity
Qiang Feng et al.
NATURE COMMUNICATIONS (2022)
Lactate metabolism in human health and disease
Xiaolu Li et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)
Tumor-Targeted Inhibition of Monocarboxylate Transporter 1 Improves T-Cell Immunotherapy of Solid Tumors
Tongyi Huang et al.
ADVANCED HEALTHCARE MATERIALS (2021)
The Chemosensitizing Role of Metformin in Anti-Cancer Therapy
Zhimin Tang et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)
SLC16 Family: From Atomic Structure to Human Disease
Patrick D. Bosshart et al.
TRENDS IN BIOCHEMICAL SCIENCES (2021)
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
Ahmad A. Cluntun et al.
CELL METABOLISM (2021)
Targeting hypoxic tumor microenvironment in pancreatic cancer
Jinxin Tao et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)
Non-coding RNAs rewire cancer metabolism networks
Xiaorong Lin et al.
SEMINARS IN CANCER BIOLOGY (2021)
Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells
Xiangru Li et al.
ONCOLOGY LETTERS (2021)
Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities
Bryce Ordway et al.
CANCERS (2021)
Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome
Martin Leu et al.
SCIENTIFIC REPORTS (2021)
Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy
Robert D. Leone et al.
CANCER IMMUNOLOGY RESEARCH (2021)
Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors
Anna-Lena Kopnick et al.
FEBS JOURNAL (2021)
Lactate in the tumour microenvironment: From immune modulation to therapy
Zi-Hao Wang et al.
EBIOMEDICINE (2021)
Role of the Heart in Lactate Shuttling
George A. Brooks
FRONTIERS IN NUTRITION (2021)
Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL).
Sarah E. R. Halford et al.
JOURNAL OF CLINICAL ONCOLOGY (2021)
Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology
Timo Heinrich et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition
Catherine Vander Linden et al.
CELL REPORTS (2021)
PXR Modulates the Prostate Cancer Cell Response to Afatinib by Regulating the Expression of the Monocarboxylate Transporter SLC16A1
Alice Matheux et al.
CANCERS (2021)
MCT1 Is a New Prognostic Biomarker and Its Therapeutic Inhibition Boosts Response to Temozolomide in Human Glioblastoma
Vera Miranda-Goncalves et al.
CANCERS (2021)
Monocarboxylate transporters in cancer
Valery L. Payen et al.
MOLECULAR METABOLISM (2020)
A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma
Ali Khammanivong et al.
VETERINARY AND COMPARATIVE ONCOLOGY (2020)
Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway
Yana Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965
Rosie McNeillis et al.
BRITISH JOURNAL OF CANCER (2020)
Competitive glucose metabolism as a target to boost bladder cancer immunotherapy
Julieta Afonso et al.
NATURE REVIEWS UROLOGY (2020)
Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon
Timothy P. Brown et al.
PHARMACOLOGY & THERAPEUTICS (2020)
Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production
Xiangyu Zhang et al.
ONCOTARGETS AND THERAPY (2020)
Comprehensive analysis of the SLC16A gene family in pancreatic cancer via integrated bioinformatics
Shan Yu et al.
SCIENTIFIC REPORTS (2020)
Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy
Fatima Baltazar et al.
FRONTIERS IN ONCOLOGY (2020)
Mechanisms of Cancer Resistance to Immunotherapy
Rilan Bai et al.
FRONTIERS IN ONCOLOGY (2020)
Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential
Xiangyu Sun et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
Reem Saleh et al.
CANCER LETTERS (2020)
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer
Lisa M. Becker et al.
CELL REPORTS (2020)
Lactate Transporters Mediate Glia-Neuron Metabolic Crosstalk in Homeostasis and Disease
Mithilesh Kumar Jha et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2020)
The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment
Yaxin Huang et al.
CANCERS (2020)
Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival
Mohamed E. Abdraboh et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
A framework for advancing our understanding of cancer-associated fibroblasts
Erik Sahai et al.
NATURE REVIEWS CANCER (2020)
Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
Xinxing Lu et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)
Lactate: A Metabolic Driver in the Tumour Landscape
Luigi Ippolito et al.
TRENDS IN BIOCHEMICAL SCIENCES (2019)
Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology
Amit J. Sabnis et al.
TRENDS IN MOLECULAR MEDICINE (2019)
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma-MCT1 as potential target in diffuse large B cell lymphoma
Julieta Afonso et al.
CELLULAR ONCOLOGY (2019)
Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors
Shirisha Jonnalagadda et al.
Oncotarget (2019)
The roles of glucose metabolic reprogramming in chemo- and radio-resistance
Jinguan Lin et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells
Chen Guo et al.
CANCER CELL INTERNATIONAL (2019)
Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
Patrick D. Bosshart et al.
NATURE COMMUNICATIONS (2019)
Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma
Sarita Saraswati et al.
CELL COMMUNICATION AND SIGNALING (2019)
Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments
Yasna Contreras-Baeza et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
Chieh-Yu Lan et al.
JOURNAL OF FOOD AND DRUG ANALYSIS (2019)
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
Kathrin Renner et al.
CELL REPORTS (2019)
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
Karen G. de la Cruz-Lopez et al.
FRONTIERS IN ONCOLOGY (2019)
Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling
Alberto Cruz-Bermudez et al.
FREE RADICAL BIOLOGY AND MEDICINE (2019)
Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70
Linda S. Forero-Quintero et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Identification of a selective inhibitor of human monocarboxylate transporter 4
Yuya Futagi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
The Science and Translation of Lactate Shuttle Theory
George A. Brooks
CELL METABOLISM (2018)
Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy
Pascale Fisel et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2018)
Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells
Qing Fan et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
Lijun Jia et al.
LIFE SCIENCES (2018)
Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation
Shizheng Li et al.
PHYTOTHERAPY RESEARCH (2018)
Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor Immunity
Lianjun Zhang et al.
TRENDS IN MOLECULAR MEDICINE (2018)
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
Cyril Corbet et al.
NATURE COMMUNICATIONS (2018)
Isoquercetin as an Adjunct Therapy in Patients With Kidney Cancer Receiving First-Line Sunitinib (QUASAR): Results of a Phase I Trial
Carlo Buonerba et al.
FRONTIERS IN PHARMACOLOGY (2018)
Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
Youdong Pan et al.
FRONTIERS IN IMMUNOLOGY (2018)
Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer
Sandra L. Romero-Cordoba et al.
SCIENTIFIC REPORTS (2018)
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD plus Depletion in Cancer Cells
Don Benjamin et al.
CELL REPORTS (2018)
miR-124 Suppresses Pancreatic Ductal Adenocarcinoma Growth by Regulating Monocarboxylate Transporter 1-Mediated Cancer Lactate Metabolism
De-Hai Wu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)
Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism
A. Cacace et al.
ONCOGENE (2017)
miR-219 attenuates demyelination in cuprizone-induced demyelinated mice by regulating monocarboxylate transporter 1
Sihan Liu et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2017)
When will small molecule lactate dehydrogenase inhibitors realize their potential in the cancer clinic?
Reshma Rani et al.
FUTURE MEDICINAL CHEMISTRY (2017)
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
Richard A. Noble et al.
HAEMATOLOGICA (2017)
Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6
Robert S. Jones et al.
MOLECULAR PHARMACEUTICS (2017)
Metabolic reprogramming in clear cell renal cell carcinoma
Hiromi I. Wettersten et al.
NATURE REVIEWS NEPHROLOGY (2017)
Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism
Tao Shan et al.
ONCOLOGY REPORTS (2017)
Value of pH regulators in the diagnosis, prognosis and treatment of cancer
Sara Granja et al.
SEMINARS IN CANCER BIOLOGY (2017)
Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment
Lekha Mikkilineni et al.
SEMINARS IN ONCOLOGY (2017)
Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma
Mahasweta Gooptu et al.
SEMINARS IN ONCOLOGY (2017)
MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis
Wanfu Xu et al.
CELL DEATH & DISEASE (2017)
Intratumoral lactate metabolism in barrett's esophagus and adenocarcinoma
Heikki Huhta et al.
ONCOTARGET (2017)
Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity
Nicola J. Curtis et al.
ONCOTARGET (2017)
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
Richard A. Noble et al.
HAEMATOLOGICA (2017)
Strategies to improve the efficacy of Dendritic Cell-Based immunotherapy for Melanoma
Kristian M. Hargadon
FRONTIERS IN IMMUNOLOGY (2017)
Attenuation of CD4+ CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug
Yuki Kunisada et al.
EBIOMEDICINE (2017)
Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression
Dillon M. Voss et al.
SCIENTIFIC REPORTS (2017)
Endothelial cell metabolism in health and disease: impact of hypoxia
Brian W. Wong et al.
EMBO JOURNAL (2017)
A first-in-human first-in-class (FIC) trial of the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with advanced solid tumours.
Sarah E. R. Halford et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
MACC1 mediates chemotherapy sensitivity of 5-FU and cisplatin via regulating MCT1 expression in gastric cancer
Chunlin Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer
Jennifer M. Johnson et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)
Metabolic coupling in urothelial bladder cancer compartments and its correlation to tumor aggressiveness
Julieta Afonso et al.
CELL CYCLE (2016)
Phloretin exhibits an anticancer effect and enhances the anticancer ability of cisplatin on non-small cell lung cancer cell lines by regulating expression of apoptotic pathways and matrix metalloproteinases
Lijie Ma et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2016)
Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy
Reshma Rani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
Ibtissam Marchiq et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2016)
The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters
Bethany Nancolas et al.
BIOCHEMICAL JOURNAL (2016)
Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine
Yangzom D. Bhutia et al.
BIOCHEMICAL JOURNAL (2016)
Phase I dose escalation study of temsirolimus in combination with metformin in patients with advanced/refractory cancers
Muhammad R. Khawaja et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)
Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation
Cyril Corbet et al.
CELL METABOLISM (2016)
In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons
Philipp Machler et al.
CELL METABOLISM (2016)
Inhibition of monocarboxylate transporter 1 suppresses the proliferation of glioblastoma stem cells
Tetsuya Takada et al.
JOURNAL OF PHYSIOLOGICAL SCIENCES (2016)
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis
Ji Yun Lee et al.
ONCOTARGET (2016)
Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters
Pavithra Viswanath et al.
ONCOTARGET (2016)
Lactate Contribution to the Tumor Microenvironment: Mechanisms, effects on immune Cells and Therapeutic Relevance
Susana Romero-Garcia et al.
FRONTIERS IN IMMUNOLOGY (2016)
Syrosingopine sensitizes cancer cells to killing by metformin
Don Benjamin et al.
SCIENCE ADVANCES (2016)
Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer
Stephanie Sprowl-Tanio et al.
CANCER & METABOLISM (2016)
Metformin Addition to Chemotherapy in Stage IV Non-Small Cell Lung Cancer: an Open Label Randomized Controlled Study
Rana Sayed et al.
Asian Pacific Journal of Cancer Prevention (2015)
Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells
Ricardo Amorim et al.
CANCER LETTERS (2015)
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang et al.
CELL (2015)
Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush
Brett M. Morrison et al.
EXPERIMENTAL NEUROLOGY (2015)
VARIANTS OF THE SOLUTE CARRIER SLC16A1 GENE (MCT1) ASSOCIATED WITH METABOLIC RESPONSES DURING A LONG-GRADED TEST IN ROAD CYCLISTS
Carlos Gonzalez-Haro et al.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH (2015)
Monocarboxylate Transporter 1 Inhibitors as Potential Anticancer Agents
Shirisha Gurrapu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Glucose metabolism regulatesT cell activation, differentiation, and functions
Clovis S. Palmer et al.
FRONTIERS IN IMMUNOLOGY (2015)
CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance
Julieta Afonso et al.
MOLECULAR CARCINOGENESIS (2015)
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status
Sara Granja et al.
ONCOTARGET (2015)
Immune Response to Cancer Therapy: Mounting an Effective Antitumor Response and Mechanisms of Resistance
Terry R. Medler et al.
TRENDS IN CANCER (2015)
Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix
Celine Pinheiro et al.
BMC CANCER (2014)
Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression
Patrizia Sanita et al.
BMC CANCER (2014)
A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer
Nelma Pertega-Gomes et al.
BMC CANCER (2014)
Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Joanne R. Doherty et al.
CANCER RESEARCH (2014)
Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival
Christina L. Roland et al.
CANCER RESEARCH (2014)
Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
Radoslaw Polanski et al.
CLINICAL CANCER RESEARCH (2014)
Stromal-epithelial metabolic coupling in gastric cancer: Stromal MCT4 and mitochondrial TOMM20 as poor prognostic factors
Z. Zhao et al.
EJSO (2014)
S-nitrosation of monocarboxylate transporter 1: Inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells
Anne R. Diers et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Synthesis and Structure Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors
Hui Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport
Becky M. Bola et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Monocarboxylate Transporter 1 Deficiency and Ketone Utilization
Peter M. van Hasselt et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration
C. J. De Saedeleer et al.
ONCOGENE (2014)
Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner
K. S. Lim et al.
ONCOGENE (2014)
Monocarboxylate Transporters 1-4 in NSCLC: MCT1 Is an Independent Prognostic Marker for Survival
Marte Eilertsen et al.
PLOS ONE (2014)
Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells
Nihed Draoui et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer
Joseph M. Curry et al.
CELL CYCLE (2013)
Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis
Guo-Xiang Ruan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Madhusudhanan Sukumar et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
The SLC16 gene family - Structure, role and regulation in health and disease
Andrew P. Halestrap
MOLECULAR ASPECTS OF MEDICINE (2013)
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets
Vera Miranda-Goncalves et al.
NEURO-ONCOLOGY (2013)
Synthesis, anti-inflammatory, and cytotoxicity evaluation of 9,10-dihydroanthracene-9,10-α,β-succinimide and bis-succinimide derivatives
Surbhi Arya et al.
MEDICINAL CHEMISTRY RESEARCH (2013)
Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle
Masaki Takimoto et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2013)
Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice
Sylvain Lengacher et al.
PLOS ONE (2013)
Cancer cell metabolism: implications for therapeutic targets
Miran Jang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2013)
Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors
Romain Boidot et al.
CANCER RESEARCH (2012)
The monocarboxylate transporter familyuRole and regulation
Andrew P. Halestrap et al.
IUBMB LIFE (2012)
Role of monocarboxylate transporters in human cancers: state of the art
Celine Pinheiro et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee et al.
NATURE (2012)
Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
Pierre Sonveaux et al.
PLOS ONE (2012)
Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
Frederique Vegran et al.
CANCER RESEARCH (2011)
Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
Hiroto Izumi et al.
CANCER SCIENCE (2011)
Evidence for a stromal-epithelial lactate shuttle in human tumors MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
Diana Whitaker-Menezes et al.
CELL CYCLE (2011)
miR-29a and miR-29b Contribute to Pancreatic β-Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)
Timothy J. Pullen et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II
Holger M. Becker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
Renaud Le Floch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
Matthew J. Ovens et al.
BIOCHEMICAL JOURNAL (2010)
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10
Matthew J. Ovens et al.
BIOCHEMICAL JOURNAL (2010)
Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma
Celine Pinheiro et al.
HISTOPATHOLOGY (2010)
Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44
Celine Pinheiro et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)
MCT1 genetic polymorphism influence in high intensity circuit training: A pilot study
Rocio Cupeiro et al.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT (2010)
Quiescent Fibroblasts Exhibit High Metabolic Activity
Johanna M. S. Lemons et al.
PLOS BIOLOGY (2010)
Interaction of monocarboxylate transporter 4 with β1-integrin and its role in cell migration
Shannon M. Gallagher et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
The reverse Warburg effect Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Stephanos Pavlides et al.
CELL CYCLE (2009)
CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models
W. Schneiderhan et al.
GUT (2009)
miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1
Kay Ka Wai Li et al.
HUMAN PATHOLOGY (2009)
Synthesis of Some Heterocyclic Imides and Azomethine Derivatives Under Solvent Free Condition and Their Anti-Inflammatory Activity Evaluation
Sham M. Sondhi et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2009)
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
Gregg L. Semenza
SEMINARS IN CANCER BIOLOGY (2009)
Sodium-coupled monocarboxylate transporters in normal tissues and in cancer
Vadivel Ganapathy et al.
AAPS JOURNAL (2008)
Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma
Celine Pinheiro et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2008)
The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-l-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells
Maria Noel Galardo et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2007)
Fibroblasts and myofibroblasts: Their source, function and role in disease
Robin J. McAnulty
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
MS Ullah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Design, synthesis, and biological evaluation of pyrrolo[2,1-c[1,4]benzodiazepine and indole conjugates as anticancer agents
JJ Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma.
MI Koukourakis et al.
CANCER RESEARCH (2006)
Monocarboxylate transporter MCT1 is a target for immunosuppression
CM Murray et al.
NATURE CHEMICAL BIOLOGY (2005)
Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4 - The ancillary protein for the insensitive MCT2 is embigin (gp70)
MC Wilson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells
U Wenzel et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: An in vitro study
SP Mathupala et al.
NEUROSURGERY (2004)
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers
K Asada et al.
ONCOLOGY (2003)
The expression of lactate transporters (MCT1 and MCT4) in heart and muscle
A Bonen
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2001)
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
P Kirk et al.
EMBO JOURNAL (2000)