Advancing beyond the twists and turns of T cell exhaustion in cancer

Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.

Automated summary

Chronic antigen stimulation leads to T cell exhaustion, which is further exacerbated by nutrient restrictions and other suppressive factors in the tumor microenvironment. Understanding the heterogeneity and dynamics of exhausted CD8 T cells will guide the development of novel therapies to modulate T cell differentiation for more effective anti-tumor responses.