Journal
SCIENCE
Volume 379, Issue 6632, Pages 554-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abo3627
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Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that occurs in children who have had benign COVID-19. In this study, autosomal recessive deficiencies of OAS1, OAS2, or RNASEL were found in five unrelated children with MIS-C. These deficiencies result in the overproduction of inflammatory cytokines by mononuclear phagocytes when stimulated by dsRNA or SARS-CoV-2.
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C.
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