Journal
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY
Volume 48, Issue 12, Pages 808-812Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S1070328422700178
Keywords
gold(III); 1,10-phenanthroline; molecular structure; biological activity; ovarian adenocarcinoma; cytotoxicity
Categories
Funding
- Russian Science Foundation
- [22-13-00175]
Ask authors/readers for more resources
The reaction between H[AuCl4] and 1,10-phenanthroline in acetonitrile resulted in the synthesis of (H(2)Phen)[AuCl4]Cl. X-ray diffraction analysis revealed the unusual doubly protonated form of phenanthroline in the complex. The complex showed high selectivity towards human ovarian carcinoma cells and low toxicity towards normal fibroblasts.
The reaction of a solution of H[AuCl4] with 1,10-phenanthroline (Phen) in acetonitrile gave the complex (H(2)Phen)[AuCl4]Cl (I). According to X-ray diffraction data (CCDC no. 2165199), Phen exists in I as an unusual doubly protonated (cationic) form (H(2)Phen)(2+). Binding of ionic structural units ([AuCl4](-), Cl-, and (H(2)Phen)(2+)) by D-H center dot center dot center dot Cl hydrogen bonds (D = N, C) gives rise to supramolecular 2D pseudo-polymer layers. The biological activity of I was measured for human ovarian carcinoma cells (SKOV3). Using MTT assay results, the half-maximal inhibitory concentration was calculated, demonstrating high selectivity of I to cancer cells in combination with low toxicity towards normal fibroblasts.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available