4.5 Article

Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A)+ RNA foci adjacent to nuclear speckles following activation of ATM (ataxia telangiectasia mutated)

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

New insights into the activities and toxicities of the old anticancer drug doxorubicin

Sabina Y. van der Zanden et al.

Summary: Doxorubicin is a commonly used chemotherapeutic drug with limited application due to severe adverse effects like cardiotoxicity, therapy-related malignancies, and gonadotoxicity. Recent studies have shown that doxorubicin causes DNA double-strand breaks and chromatin damage, the latter playing a major role in drug efficacy. Efforts are being made to develop effective analogues with limited adverse effects by understanding the mechanisms of anthracycline activities and toxicities.

FEBS JOURNAL (2021)

Review Biochemistry & Molecular Biology

The Role of TCOF1 Gene in Health and Disease: Beyond Treacher Collins Syndrome

Malgorzata Grzanka et al.

Summary: Nucleoli are membrane-less nuclear substructures responsible for ribosome biogenesis and play important roles in various cellular processes. Treacle, encoded by the TCOF1 gene, is a crucial regulator of cellular processes, involved in cancer development and other cellular activities in addition to its association with Treacher Collins syndrome.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications

John C. Chatham et al.

Summary: This review discusses the post-translational modification of proteins by O-linked N-acetylglucosamine (O-GlcNAc) in the cardiovascular system, and how dysregulation in O-GlcNAc cycling may contribute to the adverse effects of diabetes on the cardiovascular system.

CURRENT OPINION IN PHARMACOLOGY (2021)

Review Immunology

Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review

Raghad D. Alamri et al.

Summary: Leflunomide inhibits the DHODH enzyme and depletes pyrimidine nucleotides in cells, resulting in immunosuppression and antiproliferative effects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao et al.

Summary: The study reveals the mechanism of ferroptosis induced by inhibiting GPX4 in cancer cells, as well as the potential pathways to enhance or inhibit ferroptosis by intervening in relevant metabolic pathways. Therapeutic strategies targeting different levels of GPX4 expression could be a promising new approach for cancer treatment.

NATURE (2021)

Review Oncology

DHODH and cancer: promising prospects to be explored

Yue Zhou et al.

Summary: DHODH plays a crucial role in tumor progression, including de novo pyrimidine synthesis and the mitochondrial respiratory chain in cancer cells. Various DHODH inhibitors have been developed over the past decades to target DHODH and its additional effects.

CANCER & METABOLISM (2021)

Article Immunology

The role of JAK/STAT signaling pathway and its inhibitors in diseases

Ping Xin et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Article Cell Biology

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

Cristina Santoriello et al.

NATURE CELL BIOLOGY (2020)

Article Chemistry, Medicinal

Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents

Dennis P. A. Wander et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Biology

SON and SRRM2 are essential for nuclear speckle formation

Ibrahim Avsar Ilik et al.

ELIFE (2020)

Review Biochemistry & Molecular Biology

Catalytic mechanism of UDP-glucose dehydrogenase

Jun Chen et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Review Pharmacology & Pharmacy

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

Joseph T. Madak et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Article Biochemical Research Methods

Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4

Barthelemy Diouf et al.

SLAS DISCOVERY (2018)

Article Physiology

Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK

Jin-Sun Lee et al.

CHINESE JOURNAL OF PHYSIOLOGY (2018)

Article Multidisciplinary Sciences

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Marcus J. G. W. Ladds et al.

NATURE COMMUNICATIONS (2018)

Review Chemistry, Medicinal

Dihydroorotate dehydrogenase: A drug target for the development of antimalarials

Anju Singh et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

Cytarabine and daunorubicin for the treatment of acute myeloid leukemia

Tracy Murphy et al.

EXPERT OPINION ON PHARMACOTHERAPY (2017)

Review Medicine, Research & Experimental

New perspectives of physiological and pathological functions of nucleolin (NCL)

Wenyu Jia et al.

LIFE SCIENCES (2017)

Review Biology

ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses

N. Daniel Berger et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)

Review Biochemistry & Molecular Biology

The long noncoding RNA Malat1: Its physiological and pathophysiological functions

Xuejing Zhang et al.

RNA BIOLOGY (2017)

Article Multidisciplinary Sciences

Fluorescence assay of dihydroorotate dehydrogenase that may become a cancer biomarker

Sheng Yin et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Coenzyme Q biosynthesis and its role in the respiratory chain structure

Maria Alcazar-Fabra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)

Article Biochemistry & Molecular Biology

Human RNA Polymerase II Promoter Recruitment in Vitro Is Regulated by O-Linked N-Acetylglucosaminyltransferase (OGT)

Brian A. Lewis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

Richard M. Deans et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Pharmacology & Pharmacy

Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

Amit Bar-Or et al.

DRUGS (2014)

Review Genetics & Heredity

Coupling mRNA processing with transcription in time and space

David L. Bentley

NATURE REVIEWS GENETICS (2014)

Article Biochemistry & Molecular Biology

Establishment of a Monitoring System to Detect Inhibition of mRNA Processing

Ken-ichi Fujita et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

Eric P. Bennett et al.

GLYCOBIOLOGY (2012)

Review Biochemistry & Molecular Biology

Mitochondrial proton and electron leaks

Martin Jastroch et al.

ESSAYS IN BIOCHEMISTRY: MITOCHONDRIAL FUNCTION (2010)

Article Biochemistry & Molecular Biology

Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation

Stefania Millevoi et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Multidisciplinary Sciences

Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway

Anastasia A. Khutornenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Splicing factor SF3b as a target of the antitumor natural product pladienolide

Yoshihiko Kotake et al.

NATURE CHEMICAL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

A protease pathway for the repair of topoisomerase II-DNA covalent complexes

Ailing Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

Mammalian pyrimidine biosynthesis: Fresh insights into an ancient pathway

DR Evans et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Modulation of alternative pre-mRNA splicing in vivo by pinin

P Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Review Biochemistry & Molecular Biology

A unified theory of gene expression

G Orphanides et al.