4.5 Article

The hallmarks of cancer horizontal ellipsis in pituitary tumors?

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

Neuroendocrine-immune Interface: Interactions of Two Complex Systems in Health and Disease

Sandra Vela-Patino et al.

Summary: The relationship between the neuroendocrine and immune systems is crucial for maintaining homeostasis. Hormones and immune system cells have complex interactions, regulating cell differentiation, function, and cytokine production. Infiltration of immune cells is associated with disease invasiveness.

ARCHIVES OF MEDICAL RESEARCH (2022)

Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

Article Genetics & Heredity

The kinome, cyclins and cyclin-dependent kinases of pituitary adenomas, a look into the gene expression profile among tumors from different lineages

Keiko Taniguchi-Ponciano et al.

Summary: The kinome of PA clusters these lesions into three distinct groups according to the transcription factor that drives their terminal differentiation. And these complexes could be harnessed as molecular therapy targets.

BMC MEDICAL GENOMICS (2022)

Article Endocrinology & Metabolism

Fibroblast Growth Factor Receptor-4 Expression in Pituitary Adenomas is Associated with Aggressive Tumor Features

Emre Durcan et al.

Summary: The expression levels of FGFR-4 in pituitary adenomas may serve as a marker for more aggressive tumor behavior. Patients without remission, with residual lesion, and T2-hyperintense adenoma had higher median H-scores for FGFR-4.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2022)

Review Endocrinology & Metabolism

Clinical Biology of the Pituitary Adenoma

Shlomo Melmed et al.

Summary: Pituitary neoplasms are common and mostly benign, but can have diverse effects on health. Understanding the clinical biology of these neoplasms is important for implementing appropriate treatment strategies and improving quality of life and mortality.

ENDOCRINE REVIEWS (2022)

Article Biochemistry & Molecular Biology

The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas

Sergio Andonegui-Elguera et al.

Summary: This study investigated the genomic landscape of ACTH-producing adenomas and identified key gene mutations, including USP8, TP53, AURKA, EGFR, HSD3B1, and CDKN1A.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Endocrinology & Metabolism

Genetic and Epigenetic Causes of Pituitary Adenomas

Mengqi Chang et al.

Summary: This passage discusses the classification of pituitary adenomas and significant progresses in understanding their molecular biological characteristics, focusing on genetic and epigenetic variations. It also mentions several tumor predisposition syndromes related to pituitary adenomas and specific genetic mutations associated with different hormone-secreting types of adenomas.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Pituitary Remodeling Throughout Life: Are Resident Stem Cells Involved?

Emma Laporte et al.

Summary: The pituitary gland has the ability to dynamically adapt its cell composition to changing hormonal needs throughout life. Different hormonal cell populations expand during growth and development, and decline in function is associated with aging. The involvement and phenotype of pituitary stem cells in pituitary remodeling events remain largely unknown, presenting unanswered questions in pituitary research.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches

Changxi Han et al.

Summary: Macrophages are crucial infiltrating immune cells in the tumor microenvironment, and recent studies on pituitary adenoma-infiltrated macrophages have shed light on their role in tumorigenesis and progression. These advances offer promising prospects for targeting macrophages as a therapeutic strategy for pituitary adenoma.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Oncology

The Emerging Role of Non-Coding RNAs in Pituitary Gland Tumors and Meningioma

Soudeh Ghafouri-Fard et al.

Summary: Non-coding RNAs have been shown to play a significant role in the pathogenesis of pituitary gland tumors and meningiomas. Further research is needed to explore their potential applications as biomarkers for diagnosis and treatment in these brain tumors.

CANCERS (2021)

Review Oncology

Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives

Shirin Hafezi et al.

Summary: Apoptosis is the main form of cell death regulated by the BCL-2 family of proteins. Overexpression of antiapoptotic proteins in malignant cells offers survival advantages but also presents opportunities for targeted therapies. Studies targeting BCL-2 proteins, including the development of venetoclax, show promise for effective treatment in cancer.

CANCERS (2021)

Article Cell Biology

LncRNA LINC00473 is involved in the progression of invasive pituitary adenoma by upregulating KMT5A via ceRNA-mediated miR-502-3p evasion

Junjun Li et al.

Summary: The study suggests that LINC00473 is upregulated in invasive pituitary adenoma (IPA) and promotes the proliferation of PA cells through the ceRNA mechanism, possibly involving the miR-502-3p/KMT5A signaling pathway.

CELL DEATH & DISEASE (2021)

Article Clinical Neurology

EMT-Related Markers in Serum Exosomes are Potential Diagnostic Biomarkers for Invasive Pituitary Adenomas

Kelin Chen et al.

Summary: This study aimed to investigate noninvasive methods to discover viable biomarkers for assessing the invasiveness of pituitary adenomas. Through analyzing E-cadherin, N-cadherin, Epcam, TGF-beta, Smad3, and Smad7 in tissues and exosomes, the results suggested that EMT-related biomarkers in serum exosomes could potentially be used for assessing the invasiveness of pituitary adenomas.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

Review Oncology

Anti-VEGF Therapy in Refractory Pituitary Adenomas and Pituitary Carcinomas: A Review

Congxin Dai et al.

Summary: Refractory pituitary adenomas and pituitary carcinomas are difficult to treat, but anti-VEGF therapy is considered a promising alternative treatment. These tumors exhibit characteristics such as high Ki-67 index, rapid growth, frequent recurrence, and resistance to conventional treatments, and vascular endothelial growth factor plays a crucial role in these tumors.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Pangenomic Classification of Pituitary Neuroendocrine Tumors

Mario Neou et al.

CANCER CELL (2020)

Editorial Material Endocrinology & Metabolism

Editorial: Molecular Network Study of Pituitary Adenomas

Xianquan Zhan et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Pathology

Telomere length alterations and ATRX/DAXX loss in pituitary adenomas

Christopher M. Heaphy et al.

MODERN PATHOLOGY (2020)

Editorial Material Oncology

Benign vs Malignant Tumors

Aisha Patel

JAMA ONCOLOGY (2020)

Article Endocrinology & Metabolism

The Immune Profile of Pituitary Adenomas and a Novel Immune Classification for Predicting Immunotherapy Responsiveness

Zihao Wang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Review Endocrinology & Metabolism

Update on the Genetics of Pituitary Tumors

Sayka Barry et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2020)

Review Endocrinology & Metabolism

The Progress of Immunotherapy in Refractory Pituitary Adenomas and Pituitary Carcinomas

Congxin Dai et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Neurosciences

Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis

Helene Lasolle et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Transcriptome and methylome analysis reveals three cellular origins of pituitary tumors

Keiko Taniguchi-Ponciano et al.

SCIENTIFIC REPORTS (2020)

Review Biochemistry & Molecular Biology

FGF/FGFR signaling in health and disease

Yangli Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Endocrinology & Metabolism

PITX2 Expression in Non-functional Pituitary Neuroendocrine Tumor with Cavernous Sinus Invasion

Ryota Tamura et al.

ENDOCRINE PATHOLOGY (2019)

Review Endocrinology & Metabolism

Cushing's disease due to somatic USP8 mutations: a systematic review and meta-analysis

Ingrid Quevedo Wanichi et al.

PITUITARY (2019)

Article Neurosciences

Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours

Pedro Marques et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Chemistry, Multidisciplinary

Oncogene-induced senescence: a double edged sword in cancer

Xue-ling Liu et al.

ACTA PHARMACOLOGICA SINICA (2018)

Article Endocrinology & Metabolism

The USP8 mutational status may predict long-term remission in patients with Cushing's disease

Adriana Albani et al.

CLINICAL ENDOCRINOLOGY (2018)

Article Biochemistry & Molecular Biology

mTOR promotes pituitary tumor development through activation of PTTG1

R. Chen et al.

ONCOGENE (2017)

Article Oncology

Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease

Laura C. Hernandez-Ramirez et al.

ENDOCRINE-RELATED CANCER (2017)

Review Medicine, General & Internal

Diagnosis and Treatment of Pituitary Adenomas A Review

Mark E. Molitch

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Article Cell Biology

Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas

Garima Yagnik et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

Article Multidisciplinary Sciences

Lactate dehydrogenase A promotes the invasion and proliferation of pituitary adenoma

Jiayin An et al.

SCIENTIFIC REPORTS (2017)

Review Endocrinology & Metabolism

Clinically non-functioning pituitary adenomas: Pathogenic, diagnostic and therapeutic aspects

Moises Mercado et al.

ENDOCRINOLOGIA DIABETES Y NUTRICION (2017)

Article Endocrinology & Metabolism

Oncogene-Induced Senescence in Pituitary Adenomas-an Immunohistochemical Study

Emilija Manojlovic-Gacic et al.

ENDOCRINE PATHOLOGY (2016)

Article Medicine, Research & Experimental

Tumor-Suppressor Functions of the TP53 Pathway

Brandon J. Aubrey et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Review Endocrinology & Metabolism

Multiple Pituitary Adenomas: A Systematic Review

Renata M. Budan et al.

FRONTIERS IN ENDOCRINOLOGY (2016)

Article Oncology

The kinome 'at large' in cancer

Emmy D. G. Fleuren et al.

NATURE REVIEWS CANCER (2016)

Article Oncology

Evidence of cellular senescence during the development of estrogen-induced pituitary tumors

Maria Eugenia Sabatino et al.

ENDOCRINE-RELATED CANCER (2015)

Article Endocrinology & Metabolism

The Gene of the Ubiquitin-Specific Protease 8 Is Frequently Mutated in Adenomas Causing Cushing's Disease

Luis G. Perez-Rivas et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Medicine, Research & Experimental

STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion

Cuiqi Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Endocrinology & Metabolism

Clinical Characteristics and Treatment Outcome of 485 Patients with Nonfunctioning Pituitary Macroadenomas

Guadalupe Vargas et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2015)

Editorial Material Endocrinology & Metabolism

Telomere length and telomerase expression in pituitary tumors

C. S. Martins et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2015)

Article Genetics & Heredity

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

Martin Reincke et al.

NATURE GENETICS (2015)

Article Endocrinology & Metabolism

FGFR4 Polymorphic Variants Modulate Phenotypic Features of Cushing Disease

Tae Nakano-Tateno et al.

MOLECULAR ENDOCRINOLOGY (2014)

Article Medicine, General & Internal

Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation

G. Trivellin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Endocrinology & Metabolism

Apoptosis: its role in pituitary development and neoplastic pituitary tissue

M. F. Guzzo et al.

PITUITARY (2014)

Review Endocrinology & Metabolism

Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models

Carolina Cristina et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2014)

Article Multidisciplinary Sciences

Small-molecule Bax agonists for cancer therapy

Meiguo Xin et al.

NATURE COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Lactate Dehydrogenase A in Cancer: A Promising Target for Diagnosis and Therapy

Ping Miao et al.

IUBMB LIFE (2013)

Article Endocrinology & Metabolism

Enhanced nestin expression and small blood vessels in human pituitary adenomas

Maria Ines Perez-Millan et al.

PITUITARY (2013)

Article Endocrinology & Metabolism

Oncogene-induced senescence in pituitary adenomas and carcinomas

Krystallenia I. Alexandraki et al.

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2012)

Article Endocrinology & Metabolism

Expression of Ki-67, PTTG1, FGFR4, and SSTR 2, 3, and 5 in Nonfunctioning Pituitary Adenomas: A High Throughput TMA, Immunohistochemical Study

Claudia Ramirez et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Genetics & Heredity

Signaling pathway networks mined from human pituitary adenoma proteomics data

Xianquan Zhan et al.

BMC MEDICAL GENOMICS (2010)

Review Cell Biology

Pituitary senescence: The evolving role of Pttg

Vera Chesnokova et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)

Article Endocrinology & Metabolism

Cooperation between Cyclin E and p27Kip1 in Pituitary Tumorigenesis

Audrey Roussel-Gervais et al.

MOLECULAR ENDOCRINOLOGY (2010)

Editorial Material Cell Biology

Pituitary adenoma growth: A model for cellular senescence and cytokine action

Eduardo Arzt et al.

CELL CYCLE (2009)

Article Endocrinology & Metabolism

Invasive Giant Prolactinoma with Loss of Therapeutic Response to Cabergoline: Expression of Angiogenic Markers

Maria Susana Mallea-Gil et al.

ENDOCRINE PATHOLOGY (2009)

Article Endocrinology & Metabolism

Expression of p18INK4C is Down-regulated in Human Pituitary Adenomas

Md. Golam Hossain et al.

ENDOCRINE PATHOLOGY (2009)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Review Genetics & Heredity

Genome instability: a mechanistic view of its causes and consequences

Andres Aguilera et al.

NATURE REVIEWS GENETICS (2008)

Article Endocrinology & Metabolism

Clinical tumor growth and comparison with proliferation markers in non-functioning (inactive) pituitary adenomas

W. Saeger et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2008)

Review Medicine, General & Internal

Oncogene-induced cell senescence - Halting on the road to cancer

W. J. Mooi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Cell Biology

GSPα mutations in Mexican patients with acromegaly:: potential impact on long term prognosis

V Mendoza et al.

GROWTH HORMONE & IGF RESEARCH (2005)

Article Endocrinology & Metabolism

Cyclin D and cyclin E expression in normal and adenomatous pituitary

S Jordan et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.