Journal
PSYCHOLOGICAL MEDICINE
Volume 53, Issue 13, Pages 6389-6396Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291722003956
Keywords
Attention bias modification; depression; follow-up; transdiagnostic
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This study investigated the long-term effect of attention bias modification (ABM) on depressive symptoms in participants with major depressive disorder. The results showed that there was no significant difference in depression and anxiety between the ABM group and the sham group at the 6-month follow-up. While rumination decreased during the intervention, the condition did not have an impact on rumination and attentional bias. The findings suggest that ABM may not be effective in treating depressive symptoms in the long term.
BackgroundStudies investigating the long-term effect of attention bias modification (ABM) in clinical samples are lacking. This study investigates the 6-months follow-up effect of ABM on depressive symptoms in participant with major depressive disorder with and without comorbid disorders.MethodsWe conducted a double-blind randomized sham-controlled trial in 101 participants between 19 November 2019, and 17 August 2021. Follow-up ended 3 April 2022. Participants were allocated to ABM or sham condition twice daily for 14 consecutive days. Primary outcomes were the total score on the Beck Depression Inventory-II (BDI-II) at 6 months, mean Brief State Rumination Inventory (BSRI) score post-treatment and reduction in BSRI post-treatment. Secondary outcome was change in attentional bias (AB). The trial was preregistered in ClinicalTrials.gov (#NCT 04137367).ResultsA total of 118 patients aged 18-65 years were assessed for eligibility, and 101 were randomized and subjected to intention-to-treat analyses. At 6 months, ABM had no effect on depression and anxiety compared to a sham condition. While rumination decreased during the intervention, there was no effect of condition on rumination and AB. Predictor analysis did not reveal differences between participants with ongoing major depressive episode or comorbid anxiety.ConclusionCompared to sham training, there was no effect of ABM on depressive symptoms at 6-months follow-up. Since the intervention failed at modifying AB, it is unclear whether changes in AB are related to long-term outcomes.
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