Journal
PROTEOMICS
Volume 22, Issue 23-24, Pages -Publisher
WILEY
DOI: 10.1002/pmic.202200112
Keywords
ambient ionization; field portable analysis; instrumentation; miniature mass spectrometer
Funding
- National Institute of Health
- National Science Foundation
- [R01GM135432]
- [ECCS-2144216]
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This review discusses the basics, recent advancements, and application areas of portable mass spectrometers. Developing portable mass spectrometers can expand the application scope and user groups of mass spectrometry analysis and bring potential benefits to 'omics analysis.
Mass spectrometry (MS) is an information rich analytical technique and plays a key role in various 'omics studies. Standard mass spectrometers are bulky and operate at high vacuum, which hinder their adoption by the broader community and utility in field applications. Developing portable mass spectrometers can significantly expand the application scope and user groups of MS analysis. This review discusses the basics and recent advancements in the development of key components of portable mass spectrometers including ionization source, mass analyzer, detector, and vacuum system. Further, major areas where portable mass spectrometers are applied are also discussed. Finally, a perspective on the further development of portable mass spectrometers including the potential benefits for 'omics analysis is provided.
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