Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 120, Issue 1, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2210490120
Keywords
?? T cells; Staphylococcus aureus; IL-17; tissue residency; T cell memory
Categories
Funding
- Deutsche Forschungsgemeinschaft [CRC 1192, PR727/11-2, PR727/13-1, ANID/BASAL/FB210008, Conicyt/FONDEQUIP/EQM140016]
Ask authors/readers for more resources
γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance compared to other T cells in protection is unclear. Research shows that kidney-resident γδ T cells play a nonredundant role in limiting the growth of Staphylococcus aureus during chronic infection and provide enhanced protection against reinfection.
& gamma;& delta; T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of & gamma;& delta; T cells in the kidney. Renal & gamma;& delta; T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal & gamma;& delta; T cells produced IL-17A in situ and a large fraction of renal & gamma;& delta; T cells remained IL-17A+ during chronic infection. Controlled depletion revealed that & gamma;& delta; T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident & gamma;& delta; T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available