4.7 Article

A comparative study of antisolvent versus salting-out precipitations of glycopeptide vancomycin: Precipitation efficiency and product qualities

Related references

Note: Only part of the references are listed.
Article Engineering, Chemical

Salting-Out crystallization of glycopeptide Vancomycin: Phase behavior study to control the crystal habit

Siyu Pu et al.

Summary: Needle-shaped crystals in pharmaceutical manufacturing can be avoided by controlling the pH and salt concentration, as shown in this study on glycopeptide crystallization behavior. Octahedral crystals were found to be the predominant habit across a range of conditions, demonstrating higher yield and stability compared to needle-shaped crystals.

CHEMICAL ENGINEERING SCIENCE (2022)

Review Biochemistry & Molecular Biology

Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action

Mohsen Akbarian et al.

Summary: This article reviews the various production methods and sources of bioactive peptides, explores their applications in antimicrobial, antioxidant, and blood-lipid-lowering effects, and discusses the future prospects of bioactive peptides.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Engineering, Chemical

Improving the reproducibility of size distribution of protein crystals produced in continuous slug flow crystallizer operated at short residence time

Siyu Pu et al.

Summary: The development of a segmented slug flow crystallizer (SFC) design improved the reproducibility of crystal size distribution by limiting the formation of small crystals and large agglomerates, resulting in the production of lysozyme crystals with well-preserved bioactivity.

CHEMICAL ENGINEERING SCIENCE (2021)

Article Pharmacology & Pharmacy

Effect of formulation and peptide folding on the fibrillar aggregation, gelation, and oxidation of a therapeutic peptide

Maxwell Korang-Yeboah et al.

Summary: This study highlights the significance of controlled conformation in maintaining the physical and chemical stability of therapeutic peptides, with factors such as pH and ionic strength affecting the rate of fibrillar aggregation and gelation.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

Downstream Processing of Therapeutic Peptides by Means of Preparative Liquid Chromatography

Chiara De Luca et al.

Summary: The market for biomolecules with therapeutic scopes, such as peptides, is expanding continuously due to their broad range of bioactivities in the human body. The main production methods for peptides include enzymatic hydrolysis, microbial fermentation, recombinant approach, and chemical synthesis. However, these methods do not produce exclusively the target product, necessitating the removal of impurities for safety and pharmaceutical quality reasons.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Salt-Mediated Organic Solvent Precipitation for Enhanced Recovery of Peptides Generated by Pepsin Digestion

Venus Baghalabadi et al.

Summary: The inclusion of salt ions and high concentrations of acetone maximizes the recovery of peptides generated from trypsin digestion; the precipitation protocol can be extended to other organic solvents and dilute peptide samples, allowing for preconcentration and purification. The protocol captures peptides as small as 800u and is effective in recovering larger and more hydrophobic peptides.

PROTEOMES (2021)

Article Biochemical Research Methods

Anything but Conventional Chromatography Approaches in Bioseparation

Ana Cecilia Afonso Roque et al.

BIOTECHNOLOGY JOURNAL (2020)

Article Pharmacology & Pharmacy

Effects of precipitation process on the biophysical properties of highly concentrated proteins

Dae Gon Lim et al.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2020)

Article Chemistry, Physical

Hygroscopic properties of NaCl nanoparticles on the surface: a scanning force microscopy study

Xiaoxiang Wang et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2020)

Article Chemistry, Physical

What Does Nanoparticle Stability Mean?

Hoa T. Phan et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2019)

Article Biochemistry & Molecular Biology

The Effect of Dimethyl Sulfoxide on the Lysozyme Unfolding Kinetics, Thermodynamics, and Mechanism

Timur Magsumov et al.

BIOMOLECULES (2019)

Editorial Material Biotechnology & Applied Microbiology

Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

Michael Martinez et al.

TRENDS IN BIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Therapeutic peptides: Historical perspectives, current development trends, and future directions

Jolene L. Lau et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

Review Chemistry, Multidisciplinary

Green and Sustainable Solvents in Chemical Processes

Coby J. Clarke et al.

CHEMICAL REVIEWS (2018)

Article Chemistry, Multidisciplinary

Design of Bulk Protein Crystallization Based on Phase Diagrams Accounting for the Presence of Interfacial Water

Michal Kolodziej et al.

CRYSTAL GROWTH & DESIGN (2018)

Article Chemistry, Multidisciplinary

Kinetic and thermodynamic characteristics of crystallization of vancomycin

Geon-Soo Ha et al.

KOREAN JOURNAL OF CHEMICAL ENGINEERING (2017)

Article Chemistry, Applied

Downstream Processability of Crystal Habit-Modified Active Pharmaceutical Ingredient

Nawin Pudasaini et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2017)

Article Chemistry, Multidisciplinary

Selective Extraction of Collagen Peptides with High Purity from Cod Skins by Deep Eutectic Solvents

Chenjie Bai et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2017)

Review Biotechnology & Applied Microbiology

Renaissance of protein crystallization and precipitation in biopharmaceuticals purification

Raquel dos Santos et al.

BIOTECHNOLOGY ADVANCES (2017)

Review Biotechnology & Applied Microbiology

Bioprocess challenges to the isolation and purification of bioactive peptides

Dominic Agyei et al.

FOOD AND BIOPRODUCTS PROCESSING (2016)

Article Biochemical Research Methods

CIEF separation, UV detection, and quantification of ampholytic antibiotics and bacteria from different matrices

Marie Horka et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2014)

Article Biochemical Research Methods

Introduction to protein crystallization

Alexander McPherson et al.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2014)

Article Chemistry, Multidisciplinary

Needle-Shaped Crystals: Causality and Solvent Selection Guidance Based on Periodic Bond Chains

Michael A. Lovette et al.

CRYSTAL GROWTH & DESIGN (2013)

Article Biochemistry & Molecular Biology

Mechanistic insights into protein precipitation by alcohol

Hiroki Yoshikawa et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2012)

Article Chemistry, Multidisciplinary

What's in a Drop? Correlating Observations and Outcomes to Guide Macromolecular Crystallization Experiments

Joseph R. Luft et al.

CRYSTAL GROWTH & DESIGN (2011)

Article Chemistry, Multidisciplinary

Systematic evaluation and optimization of crystallization conditions for vancomycin purification

Ji-Yeon Lee et al.

KOREAN JOURNAL OF CHEMICAL ENGINEERING (2010)

Article Food Science & Technology

Comparative studies on the functional properties of various protein concentrate preparations of peanut protein

Haiwen Wu et al.

FOOD RESEARCH INTERNATIONAL (2009)

Letter Biochemistry & Molecular Biology

Announcing the worldwide Protein Data Bank

H Berman et al.

NATURE STRUCTURAL BIOLOGY (2003)

Article Biochemical Research Methods

Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography-tandem mass spectrometry

C Polson et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2003)

Article Chemistry, Multidisciplinary

Effect of moisture on the stability of a lyophilized humanized monoclonal antibody formulation

ED Breen et al.

PHARMACEUTICAL RESEARCH (2001)

Article Biotechnology & Applied Microbiology

Stability of crystalline proteins

B Shenoy et al.

BIOTECHNOLOGY AND BIOENGINEERING (2001)

Review Pathology

x Ray crystallography

MS Smyth et al.

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY (2000)