In-vitro release studies of ciprofloxacin drug using polyaniline/polypyrrole-encapsulated β-cyclodextrin nanocomposites

The present study reports the synthesis of nanocomposites of beta-cyclodextrin (beta-CD) with polyaniline (PANI) and polypyrrole (PPy) to design core-shell nanocomposites. The synthesized nanocomposites were investigated for their spectral, morphological and thermal characteristics. IR spectra confirmed the incorporation of PANI and PPy in beta-CD by the strong interaction between NH of PANI/PPY and OH of beta-CD, while the ultraviolet (UV)-visible spectra confirmed the polaronic state of conducting polymers in the nanocomposites. The scanning electron microscopy (SEM) analysis revealed the core-shell like morphology of the nanocomposites. Ciprofloxacin (CIP) was chosen as a model drug to study the in-vitro drug release as gastric (pH 1.2) and intestinal (pH 7.4) values by loading the drug (50 mg) into the pristine polymers as well as beta-CD nanocomposites. The nanocomposites were found to show the sustained release behavior and hold potential to be used as an effective antibiotic drug delivery vehicle.

Automated summary

The synthesis of nanocomposites of beta-cyclodextrin (beta-CD) with polyaniline (PANI) and polypyrrole (PPy) to design core-shell nanocomposites was reported in this study. The spectral, morphological, and thermal characteristics of the synthesized nanocomposites were investigated. The incorporation of PANI and PPy in beta-CD was confirmed by IR spectra, while UV-visible spectra confirmed the polaronic state of conducting polymers in the nanocomposites. SEM analysis revealed the core-shell like morphology of the nanocomposites. In vitro drug release studies using ciprofloxacin (CIP) showed sustained release behavior of the nanocomposites, indicating their potential as effective antibiotic drug delivery vehicles.