A study on the applications of 3-amino quinoline complexes of Pd(II) as catalysts for the Suzuki-Miyaura coupling of aryl halides in aqueous and organic media

A novel series of stable phosphine/arsine-free Schiff base Pd(II) complexes (1-3) was synthesized and investi-gated using a variety of spectroscopic techniques and single crystal X-ray crystallography. A square-planar distortion was observed in all complexes centering on the Pd(II) ion. The isolated complexes (1-3) were used as catalysts for the Suzuki cross-coupling reactions in water/ethanol and water medium, resulting in good to excellent yields of the products even with a little loading of the catalyst. This methodology has the potential to be extended further to develop novel antimicrobial drugs, which can be further used in the treatment of infectious diseases.

Automated summary

A series of stable phosphine/arsine-free Schiff base Pd(II) complexes (1-3) were synthesized and investigated, exhibiting a square-planar distortion around the Pd(II) ion. These complexes were used as catalysts for Suzuki cross-coupling reactions in water/ethanol and water medium, showing high catalytic activity even with low catalyst loading. This methodology has the potential to be applied in the development of novel antimicrobial drugs for infectious diseases.