4.6 Article

Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants

Yan-yan Li et al.

Summary: Through meta-analysis, we found a significant association between MTNR1B gene rs10830963 C/G polymorphism and T2DM in the Chinese population, suggesting that individuals with the G allele might be more susceptible to T2DM.

HELIYON (2022)

Article Endocrinology & Metabolism

Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population

Yumin Ma et al.

Summary: The low-frequency variant of GCK gene, rs13306393, was found to be associated with type 2 diabetes and prediabetes in the Chinese population. This variant increased the risk of developing diabetes and prediabetes by reducing insulin sensitivity rather than affecting beta-cell function, which should be considered in future clinical use of GCK activators.

DIABETES (2021)

Article Endocrinology & Metabolism

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations, treatment goals, guidelines, and tools for evaluating care quality. It is updated annually by a multidisciplinary expert committee, and readers are invited to comment on the standards at professional.diabetes.org/SOC.

DIABETES CARE (2021)

Article Genetics & Heredity

SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population

Safaa Mashal et al.

Summary: The study identified a significant association between the rs13266634 SNP and type 2 diabetes mellitus (T2DM) susceptibility among the Jordanian population. Carrying the C allele was found to be associated with a higher risk of T2DM, and having a CC genotype versus TT genotype was significantly associated with an increased risk of T2DM after adjusting for age, gender, and BMI.
Article Cardiac & Cardiovascular Systems

Neuronal Differentiation 1 gene Ala45Thr polymorphism and type 2 diabetes mellitus: A meta-analysis of 7,940 subjects

Yan-Yan Li et al.

Summary: The meta-analysis showed a significant association between NEUROD1 gene Ala45Thr polymorphism and T2DM, especially in the Asian population, with Thr45 allele carriers being more susceptible to T2DM.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

Article Endocrinology & Metabolism

Incidence and pathophysiology of diabetes in South Asian adults living in India and Pakistan compared with US blacks and whites

K. M. Venkat Narayan et al.

Summary: The study showed that South Asian adults have lower BMI and are less insulin resistant compared to US blacks and whites, but have a higher incidence of diabetes than US whites, especially in non-obese subgroups. Factors other than insulin resistance, such as insulin secretion, may play a significant role in the development of diabetes in South Asians.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

Article Endocrinology & Metabolism

Replacement of Sedentary Behavior by Various Daily-Life Physical Activities and Structured Exercises: Genetic Risk and Incident Type 2 Diabetes

Xiang Li et al.

Summary: This study found that sedentary behavior time is associated with an increased risk of T2D; replacing sedentary behavior with a short duration of daily-life physical activities or structured exercise is related to a significant reduction in T2D risk. Furthermore, such association was stronger among those with a lower genetic risk of T2D.

DIABETES CARE (2021)

Article Endocrinology & Metabolism

Association of HLA-B Gene Polymorphisms with Type 2 Diabetes in Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan

Asif Jan et al.

Summary: The study suggests that the rs2308655 variant in the HLA-B gene may be a risk variant for T2D susceptibility in the Pashtun population. Through WES and MassARRAY analysis, the association between genetic polymorphism and T2D was identified.

JOURNAL OF DIABETES RESEARCH (2021)

Article Public, Environmental & Occupational Health

One Size Does Not Fit All: Diabetes Prevalence Among Immigrants of the South Asian Diaspora

Ananya Tina Banerjee et al.

Summary: The risk of diabetes is higher in South Asians compared to the general population, with significant variations in prevalence among different subgroups. Men have a higher prevalence compared to women in each subgroup. The study emphasizes the impact of unique migration histories on the risk and burden of diabetes among South Asians, urging the development of targeted interventions in Ontario.

JOURNAL OF IMMIGRANT AND MINORITY HEALTH (2021)

Article Multidisciplinary Sciences

PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis

Negar Sarhangi et al.

SCIENTIFIC REPORTS (2020)

Review Medicine, General & Internal

Diabetes in Pakistan: A systematic review and meta-analysis

Sohail Akhtar et al.

PAKISTAN JOURNAL OF MEDICAL SCIENCES (2019)

Review Public, Environmental & Occupational Health

The Play of Genes and Non-genetic Factors on Type 2 Diabetes

Michael Mambiya et al.

FRONTIERS IN PUBLIC HEALTH (2019)

Article Biochemistry & Molecular Biology

Association of VEGFA variants with altered VEGF secretion and type 2 diabetes: A case-control study

Nejla Sellami et al.

CYTOKINE (2018)

Article Endocrinology & Metabolism

Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients

Sahar A. Sharaf et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Article Medicine, Research & Experimental

Association of melatonin receptor 1 B gene (rs10830963 and rs9192552) polymorphsm with adolescent obesity and related comorbidities in Turkey

Nilgun Col et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2018)

Article Endocrinology & Metabolism

Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients

Ji Sun Nam et al.

ENDOCRINOLOGY AND METABOLISM (2018)

Review Endocrinology & Metabolism

Gene-environment interaction in type 2 diabetes

Yoshiaki Kido

DIABETOLOGY INTERNATIONAL (2017)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Biochemistry & Molecular Biology

RAMICS: trainable, high-speed and biologically relevant alignment of high-throughput sequencing reads to coding DNA

Imogen A. Wright et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Medicine, General & Internal

Genetic variants in MTNR1B affecting insulin secretion

Karsten Muessig et al.

ANNALS OF MEDICINE (2010)

Article Endocrinology & Metabolism

The PPAR gamma Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects

Dimitry A. Chistiakov et al.

DIABETES & VASCULAR DISEASE RESEARCH (2010)

Article Biochemistry & Molecular Biology

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

Aaron McKenna et al.

GENOME RESEARCH (2010)

Article Biochemistry & Molecular Biology

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

Kai Wang et al.

NUCLEIC ACIDS RESEARCH (2010)

Editorial Material Cell Biology

Autophagy and the pancreatic beta-cell in human type 2 diabetes

Piero Marchetti et al.

AUTOPHAGY (2009)

Article Biochemical Research Methods

The Sequence Alignment/Map format and SAMtools

Heng Li et al.

BIOINFORMATICS (2009)

Article Endocrinology & Metabolism

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

P. Marchetti et al.

DIABETOLOGIA (2007)

Article Genetics & Heredity

Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu et al.

NATURE GENETICS (2007)

Article Endocrinology & Metabolism

Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes

AM Bagwell et al.

DIABETES (2005)