Journal
PIGMENT CELL & MELANOMA RESEARCH
Volume 36, Issue 3-4, Pages 268-287Publisher
WILEY
DOI: 10.1111/pcmr.13081
Keywords
melanoma; epigenetics; miRNAs; nanodelivery; signaling pathways; stemness
Categories
Ask authors/readers for more resources
miRNAs play a significant role in cancer proliferation, mitigation, and drug resistance. Nanocarriers carrying tumor-targeting miRNAs are a promising strategy to modulate stemness and overcome the limitations of low penetrability, minimal stability, and nonspecificity. Specific nanocarrier formulations with specific miRNAs can efficiently deliver therapeutic effects in melanomas by targeting tumor properties.
Several research reports delineated the significant role of miRNAs in cancer proliferation, and their modulatory role in cancer mitigation, and drug resistance. Melanoma cells have been acquiring stemness to several chemotherapeutic agents through drug efflux proteins, epigenetic modulation, and DNA repair. miRNAs could be applied as novel therapeutic modalities for treating several kinds of cancers to modulate these mechanisms involved in stemness. Nanocarriers to carry these tumor-targeting miRNAs to modulate stemness are a prominent strategy to overcome their low penetrability, minimal stability, and nonspecificity. We have searched several public databases such as PubMed, Medline, Google scholar, and NLM and obtained the information pertinent to the miRNA-based nanocarrier systems to target stemness through epigenetic modulation in melanomas. This review delineates that various miRNAs can modulate the stemness in melanomas by specific intricate epigenetic signaling, and other cell-based signaling mechanisms. Specific nanocarrier formulations with specific miRNAs are optimal methods to deliver these miRNAs in order to achieve significant entrapment efficiency, loading efficiency, and stability. Furthermore, the combinatorial regimen of FDA-approved chemotherapeutic molecules with tumor-targeting miRNAs and chemotherapy combined with nanocarriers can efficiently deliver the utmost therapeutic window by targeting tumor matrix, invasion, metastasis, and angiogenesis in melanomas. Substantial research should focus on the clinical application of this gene therapy in melanomas using these low immunogenic, highly degradable, and biocompatible combinatorial nanotherapeutic regimens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available