4.7 Review

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Zinat Heidari et al.

Summary: Curcumin supplementation in children shows clinical efficacy in inflammatory, immune disorders, and metabolic diseases, with good tolerability. However, further studies on ADPKD, CF, TOF, and infectious diseases are needed to confirm the results.

PHYTOTHERAPY RESEARCH (2022)

Article Nutrition & Dietetics

Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

Amir Vahedian-Azimi et al.

Summary: This systematic review investigates the efficacy of curcumin supplementation in COVID-19 patients. The findings suggest that curcumin supplementation can significantly decrease symptoms, duration of hospitalization, and deaths. It also shows that curcumin helps balance pro-inflammatory and anti-inflammatory factors, improving the cytokine storm effect. Overall, curcumin supplementation may offer a safe and effective option for improving COVID-19 disease outcomes.

NUTRIENTS (2022)

Review Integrative & Complementary Medicine

Curcumin as adjuvant treatment in patients with non-alcoholic fatty liver (NAFLD) disease: A systematic review and meta-analysis

M. H. Ngu et al.

Summary: Curcumin supplementation has a beneficial effect on liver ultrasonographic findings and reduces serum liver enzymes, total cholesterol, and BMI in NAFLD patients. Promoting curcumin as adjuvant treatment for NAFLD patients is justified.

COMPLEMENTARY THERAPIES IN MEDICINE (2022)

Article Medicine, Research & Experimental

The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial

Gholamreza Askari et al.

Summary: The present study found that curcumin-piperine co-supplementation significantly reduced weakness in outpatients with COVID-19. However, there was no significant effect on other indices, including biochemical and clinical indices.

TRIALS (2022)

Review Biochemistry & Molecular Biology

Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review

Zhi-Jun Yang et al.

Summary: This article provides an updated review on the prevention and management of cancers using curcumin, with a special focus on its mechanisms of action. Curcumin exhibits various anticancer properties and has been shown to inhibit cell proliferation and promote cell apoptosis. Clinical trials have also confirmed its anticancer effects. Furthermore, the use of nanotechnologies can enhance the bioavailability of curcumin.

ANTIOXIDANTS (2022)

Review Chemistry, Medicinal

Protective effects of curcumin on ischemia/reperfusion injury

Malihe Mohamadian et al.

Summary: Ischemia/reperfusion injury refers to tissue damage caused by reperfusion after ischemic injury. Therapeutic outcomes for this condition still need improvement. Curcumin, derived from turmeric, has been found to have strong anti-inflammatory and antioxidant properties, and it plays a protective role in various organs against I/R injury.

PHYTOTHERAPY RESEARCH (2022)

Review Chemistry, Medicinal

Piperine: A review of its biological effects

Iahtisham-Ul Haq et al.

Summary: Black pepper, as a commonly used medicinal plant, has various pharmacological effects and health-promoting properties, making it a potential therapeutic agent for several diseases.

PHYTOTHERAPY RESEARCH (2021)

Article Medicine, General & Internal

Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model

Eman Shawky Mohammed et al.

Summary: The study aimed to enhance the bioavailability of curcumin by using nanoparticles, and results showed that nanoparticulate curcumin had significant therapeutic effects on hepatocellular carcinoma induced by diethylnitrosamine in mice.

ARCHIVES OF MEDICAL SCIENCE (2021)

Review Biochemistry & Molecular Biology

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

Babak Alikiaii et al.

Summary: Sepsis and septic shock remain significant causes of mortality and morbidity worldwide, characterized by an uncontrolled immune response and excessive pro-inflammatory mediator production. Understanding the pathophysiology and molecular mechanisms of sepsis can aid in the development of new effective therapeutics. Natural bioactive herbal compounds and phytochemicals show promise in attenuating inflammatory responses and offering cytoprotective effects in sepsis patients.

BIOFACTORS (2021)

Review Nutrition & Dietetics

Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials

Jessica J. A. Ferguson et al.

Summary: This systematic review aimed to evaluate the efficacy of curcumin supplementation on systemic inflammatory mediators, providing evidence for the anti-inflammatory effects of curcumin. However, discrepancies regarding optimal dosage, duration, and formulation of curcumin still exist.

NUTRITION REVIEWS (2021)

Review Chemistry, Medicinal

Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

Saba Soltani et al.

Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.

PHYTOTHERAPY RESEARCH (2021)

Article Food Science & Technology

Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial

Joana Furtado de Figueiredo Neta et al.

Summary: The study provides strong evidence that Curcuma longa L. can effectively reduce metabolic levels in individuals with diabetes, especially in the glycemic and triglyceride control of patients with type 2 diabetes.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2021)

Review Nutrition & Dietetics

Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes-A Meta-Analysis of Randomized Controlled Trial

Emma Altobelli et al.

Summary: The study demonstrated that curcumin has a positive impact on glycemic and lipid profiles in subjects with uncomplicated type 2 diabetes, showing significant reductions in glycosylated hemoglobin, HOMA, and LDL. However, further research is needed to test the efficacy and safety of curcumin in this population.

NUTRIENTS (2021)

Review Chemistry, Medicinal

The clinical use of curcumin on neurological disorders: An updated systematic review of clinical trials

Maryam Mohseni et al.

Summary: Curcumin has been shown to have neuroprotective effects in neurological disorders, with positive impacts on oxidative stress and inflammation. While it may provide beneficial effects on clinical outcomes for various neurodegenerative diseases, adverse side effects were reported in some studies. Overall, curcumin supplementation may have favorable effects on inflammatory status and clinical outcomes in patients with neurological diseases, although the results were not consistently positive.

PHYTOTHERAPY RESEARCH (2021)

Article Chemistry, Medicinal

Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial

Hoda Zahedi et al.

Summary: The study showed that short-term supplementation with curcuminoids can significantly reduce inflammation levels, improve clinical outcomes, and enhance nutritional status in patients with TBI.

PHYTOTHERAPY RESEARCH (2021)

Article Pharmacology & Pharmacy

Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial

Kirti S. Pawar et al.

Summary: The study found that using curcumin/piperine treatment in COVID-19 can improve symptoms, reduce deterioration, and improve clinical outcomes. In addition, curcumin/piperine treatment also appears to shorten hospitalization for severe patients and reduce mortality.

FRONTIERS IN PHARMACOLOGY (2021)

Review Chemistry, Medicinal

Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies

Babak Alikiaii et al.

Summary: Curcumin ameliorates the severity of pneumonia by reducing neutrophil infiltration and ameliorating the exaggerated immune response in preclinical pneumonia models.

PHYTOTHERAPY RESEARCH (2021)

Article Pharmacology & Pharmacy

Piperine Is a Mechanism-Based Inactivator of CYP3A

Tiantian Cui et al.

DRUG METABOLISM AND DISPOSITION (2020)

Review Food Science & Technology

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

Sita Sharan Patel et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Article Integrative & Complementary Medicine

Effects of curcuminoids on inflammatory status in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Maryam Saberi-Karimian et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2020)

Review Chemistry, Medicinal

Potential effects of curcumin in the treatment ofCOVID-19 infection

Fatemeh Zahedipour et al.

PHYTOTHERAPY RESEARCH (2020)

Review Food Science & Technology

The potential role of plant-derived natural products in improving arterial stiffness: A review of dietary intervention studies

Mona Alidadi et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

Review Pharmacology & Pharmacy

Curcumin: an inflammasome silencer

Shima Hasanzadeh et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Pharmacology & Pharmacy

Piperine: Old Spice and New Nutraceutical?

Katarina Smilkov et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Biochemistry & Molecular Biology

Is curcumin bioavailability a problem in humans: lessons from clinical trials

Ajaikumar B. Kunnumakkara et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2019)

Article Biochemistry & Molecular Biology

Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

Yunes Panahi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

Raghavendhar R. Kotha et al.

MOLECULES (2019)

Review Food Science & Technology

Immune modulation by curcumin: The role of interleukin-10

Hamid Mollazadeh et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

Article Dentistry, Oral Surgery & Medicine

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis

Basudev Mahato et al.

CONTEMPORARY CLINICAL DENTISTRY (2019)

Review Immunology

Curcumin: A natural modulator of immune cells in systemic lupus erythematosus

Amir Abbas Momtazi-Borojeni et al.

AUTOIMMUNITY REVIEWS (2018)

Review Pharmacology & Pharmacy

Therapeutic potential of curcumin in diabetic complications

Negin Parsamanesh et al.

PHARMACOLOGICAL RESEARCH (2018)

Review Biochemistry & Molecular Biology

Obesity and inflammation

Jacek Karczewski et al.

EUROPEAN CYTOKINE NETWORK (2018)

Review Plant Sciences

Pharmacokinetic interactions of curcuminoids with conventional drugs: A review

Roodabeh Bahramsoltani et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

Article Chemistry, Medicinal

The Essential Medicinal Chemistry of Curcumin

Kathryn M. Nelson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

Effects of curcumin on HDL functionality

Shiva Ganjali et al.

PHARMACOLOGICAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus

Yunes Panahi et al.

CURRENT CLINICAL PHARMACOLOGY (2017)

Review Food Science & Technology

Curcumin: A Review of Its Effects on Human Health

Susan J. Hewlings et al.

FOODS (2017)

Article Integrative & Complementary Medicine

Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

Yunes Panahi et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2017)

Article Medicine, General & Internal

Obesity and inflammation: the linking mechanism and the complications

Mohammed S. Ellulu et al.

ARCHIVES OF MEDICAL SCIENCE (2017)

Review Gastroenterology & Hepatology

A mechanistic review on plant-derived natural compounds as dietary supplements for prevention of inflammatory bowel disease

Mohammad Hosein Farzaei et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Chemistry, Medicinal

Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial

A. Khonche et al.

DRUG RESEARCH (2016)

Review Biochemistry & Molecular Biology

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

Kavirayani Indira Priyadarsini

MOLECULES (2014)

Article Cell Biology

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Article Medicine, Research & Experimental

Piperine potentiates the hypocholesterolemic effect of curcumin in rats fed on a high fat diet

Yaosheng Tu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2014)

Review Biochemistry & Molecular Biology

Curcumin and obesity

Peter G. Bradford

BIOFACTORS (2013)

Article Pharmacology & Pharmacy

Piperine and curcumin exhibit synergism in attenuating D-galactose induced senescence in rats

David Banji et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

Review Chemistry, Medicinal

Piper nigrum and Piperine: An Update

Murlidhar Meghwal et al.

PHYTOTHERAPY RESEARCH (2013)

Article Gastroenterology & Hepatology

Therapeutic potential of curcumin in digestive diseases

Pietro Dulbecco et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

Article Chemistry, Multidisciplinary

Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model

Li-hua Lai et al.

ACTA PHARMACOLOGICA SINICA (2012)

Review Chemistry, Multidisciplinary

CurcuminuFrom Molecule to Biological Function

Tuba Esatbeyoglu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Food Science & Technology

Combined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damage

A. Sehgal et al.

FOOD AND CHEMICAL TOXICOLOGY (2011)

Article Agriculture, Multidisciplinary

Rapid Analysis of Curcumin and Curcumin Metabolites in Rat Biomatrices Using a Novel Ultraperformance Liquid Chromatography (UPLC) Method

Timothy H. Marczylo et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

Review Pharmacology & Pharmacy

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

Bharat B. Aggarwal et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Review Biochemistry & Molecular Biology

Curcumin: From ancient medicine to current clinical trials

H. Hatcher et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Biochemical Research Methods

Oral bioavailabilit of curcurnin in rat and the herbal analysis from Curcuma longa by LC-MS/MS

Kuo-Yi Yang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)

Review Food Science & Technology

Black pepper and its pungent principle-piperine: A review of diverse physiological effects

K. Srinivasan

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2007)

Article Medicine, Research & Experimental

Multiple biological activities of curcumin: A short review

RK Maheshwari et al.

LIFE SCIENCES (2006)

Article Agriculture, Multidisciplinary

Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver

SI Hoehle et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2006)