4.7 Letter

Gut microbial considerations and feasibility of phytochemicals as anti-COVID prophylaxis: Critical role of bioavailability

Related references

Note: Only part of the references are listed.
Article Biology

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

Alvaro A. Ordonez et al.

Summary: This study evaluated the antiviral activity of sulforaphane (SFN) against SARS-CoV-2 and found that SFN can inhibit the replication of multiple strains of SARS-CoV-2 and seasonal coronaviruses. Prophylactic SFN treatment can reduce viral load, lung injury, and immune cell activation in infected mice.

COMMUNICATIONS BIOLOGY (2022)

Review Biochemistry & Molecular Biology

The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist-from fundamentals to future challenges

Priyankar Dey et al.

Summary: The role of the intestine in human health and disease is crucial, and studies on intestinal microbiota and metabolites have enhanced our understanding of their relationship. Research on the effects of dietary phytochemicals on microbial metabolites in the gut is also a key focus.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Chemistry, Medicinal

Plant-derived chemicals as potential inhibitors of SARS-CoV-2 main protease (6LU7), a virtual screening study

Mohsen Sisakht et al.

Summary: A dataset of plant-based natural compounds was screened for antiviral activity against SARS-CoV-2 main protease, with several phytochemicals identified as potential inhibitors that could be used in the fight against COVID-19.

PHYTOTHERAPY RESEARCH (2021)

Review Chemistry, Medicinal

Antiinflammatory phytochemicals against virus-induced hyperinflammatory responses: Scope, rationale, application, and limitations

Manoj Baranwal et al.

Summary: This review highlights the potential of anti-inflammatory phytochemicals in limiting hyperinflammatory injury caused by viral infections, including their mechanisms in modulating gut microbiota and maintaining intestinal barrier integrity. It also discusses strategies for improving systemic bioavailability of phytochemicals, effective delivery methods, safety measures, and the importance of well-controlled clinical studies to establish the efficacy of phytochemicals in reducing pro-inflammatory injury associated with viral infections.

PHYTOTHERAPY RESEARCH (2021)

Review Biochemistry & Molecular Biology

Pharmacological benefits of Acacia against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota

Manas Ranjan Saha et al.

Summary: Plants belonging to the genera Acacia have shown potential benefits for metabolic health at the intestinal level including increasing beneficial gut bacteria and reducing harmful pathogens, providing anti-inflammatory effects and potentially improving gut barrier function to prevent endotoxin translocation and limit low-grade inflammation associated with metabolic diseases.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Metabolism and Pharmacokinetics of Phytochemicals in the Human Body

Pooja Rathaur et al.

CURRENT DRUG METABOLISM (2019)

Review Biochemistry & Molecular Biology

Bioavailability of Tea Catechins and Its Improvement

Zhuo-Yu Cai et al.

MOLECULES (2018)

Article Pharmacology & Pharmacy

The gut microbiota: A key factor in the therapeutic effects of (poly) phenols

Juan Carlos Espin et al.

BIOCHEMICAL PHARMACOLOGY (2017)

Review Plant Sciences

Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?

Feng Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

Stability of (-)-epigallocatechin gallate and its activity in liquid formulations and delivery systems

Olga Krupkova et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2016)

Article Agriculture, Multidisciplinary

Kinetic Study of Catechin Stability: Effects of pH, Concentration, and Temperature

Na Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

Review Chemistry, Medicinal

Bioavailability Challenges Associated with Development of Anti-Cancer Phenolics

S. Gao et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2010)

Review Oncology

Interindividual differences in phytochemical metabolism and disposition

Johanna W. Lampe et al.

SEMINARS IN CANCER BIOLOGY (2007)