Journal
PHYTOCHEMISTRY LETTERS
Volume 53, Issue -, Pages 150-154Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2022.12.004
Keywords
Gerbera piloselloides; Glycosides; Structural identification; Intestinal epithelial cells (IEC-6)
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Four new glycosides, along with six known compounds, were isolated from the whole plant of Gerbera piloselloides. Their structures and absolute configurations were determined using extensive spectroscopic data and X-ray diffraction analysis. Among them, compounds 3 and 4 showed moderate promotion of proliferation in lipopolysaccharide-induced intestinal epithelial cells.
Four new glycosides, named 3-dehydroxyl dracunculifoside J (1), 4-methoxy divaricataester C (2), 6 '-O-acetyl gerberinside (3), and 4-methoxy marmesinin (4), along with six known compounds (5-10), were isolated from the whole plant of Gerbera piloselloides. Structurally, their structures and absolute configurations were established based on extensive spectroscopic data and X-ray diffraction analysis. Compounds 1-4 were evaluated for the protective effect on lipopolysaccharide (LPS)-induced injury in intestinal epithelial cells (IEC-6). Among them, 3 and 4 could moderately promote the proliferation of LPS-induced IEC-6 cells.
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