Journal
PHYTOCHEMISTRY
Volume 205, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113478
Keywords
Valeriana officinalis; Caprifoliaceae; Iridoids; Sesquiterpenoids; Anti-inflammatory; Anti -influenza virus
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In this study, twenty-six iridoids and ten sesquiterpenoids were isolated from the roots and rhizomes of Valeriana officinalis. One of the isolated iridoids, named iridoidvol A, is the first example of an iridoid with sesquiterpenoid acid ester. Additionally, isovaltrate isovaleroyloxyhydrin exhibited a significant inhibitory effect on NO production.
Twenty-six iridoids, including six undescribed ones (iridoidvols A-F) and an undescribed natural one, along with ten known sesquiterpenoids were isolated from the roots and rhizomes of Valeriana officinalis. Structurally, iridoidvol A is the first example of iridoid with sesquiterpenoid acid ester. In addition, all of the isolates were evaluated for anti-inflammatory and anti-influenza virus activities. Among them, isovaltrate isovaleroyloxyhydrin exhibited a significant inhibitory effect on NO production with an IC50 value of 19.00 mu M.
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