4.5 Article

Tanycyte, the neuron whisperer

Related references

Note: Only part of the references are listed.
Letter Cell Biology

Tanycytes and hypothalamic FGF21: New players in the metabolic game

Sarah Geller et al.

CELL REPORTS (2023)

Article Cell Biology

Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions

Monica Imbernon et al.

Summary: Liraglutide is transported to the hypothalamus by specialized ependymoglial cells called tanycytes, bypassing the blood-brain barrier. Silencing GLP1R in tanycytes or inhibiting tanycytic transport blocks the effects of liraglutide on hypothalamic neurons and its anti-obesity effects.

CELL METABOLISM (2022)

Article Multidisciplinary Sciences

GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting

M. J. Barahona et al.

Summary: This study found that a GLUT2-dependent glucose-sensing mechanism in GFAP-positive tanycytes is crucial for the normal regulation of feeding behavior. Inactivation of GLUT2 in GFAP-positive tanycytes led to delayed meal initiation and decreased food intake after fasting. The loss of glucose sensing also resulted in an increase in c-Fos-positive cells in the ventromedial nucleus and deregulation of Pomc expression in the fasting-to-refeeding transition.

SCIENTIFIC REPORTS (2022)

Article Cell Biology

Central FGF21 production regulates memory but not peripheral metabolism

Bolu Zhou et al.

Summary: The study reveals that FGF21 is not expressed in the hypothalamus, but in the retrosplenial cortex (RSC), and it enhances spatial memory in the hippocampus without regulating energy homeostasis or sugar intake.

CELL REPORTS (2022)

Article Cell Biology

Release of VAMP5-positive extracellular vesicles by retinal Muller glia in vivo

Valerie Demais et al.

Summary: This study reveals the communication mechanism of Muller cells in the retina of adult mice through the release of extracellular vesicles. The Muller cell-specific SNARE protein VAMP5 is identified as a component of extracellular vesicles and is responsive to ischemia. Furthermore, differences in the secretomes between Muller cells and neurons in vitro are uncovered.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Review Endocrinology & Metabolism

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

Sreekala Nampoothiri et al.

Summary: This review discusses the key role glial cells play in regulating energy balance, emphasizing their relevance in the pathophysiology of metabolic diseases. Glial cells, located at the interface of blood vessels and neurons, participate in integrating and transmitting peripheral signals to neuronal networks in the brain for whole-body metabolism control. Metabolic diseases like obesity and type 2 diabetes can disrupt the communication mediated by glial cells between the brain and the periphery, highlighting the importance of these cell types in the pathophysiology of such complications.

NATURE METABOLISM (2022)

Article Endocrinology & Metabolism

Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21

Veronica Pena-Leon et al.

Summary: Delayed weaning can protect rats from diet-induced obesity in adulthood by increasing thermogenesis and energy expenditure. This protective mechanism is mediated by liver-produced FGF21 signaling to the hypothalamus.

NATURE METABOLISM (2022)

Article Neurosciences

Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice

Celine Cansell et al.

Summary: Obesity in humans is associated with brain inflammation, glial reactivity, and immune cell infiltration. Studies in rodents have shown that glial reactivity occurs shortly after consuming a high-fat diet, even before obesity develops, primarily in the hypothalamus. This postprandial inflammation in the brain may contribute to the development of obesity and requires further characterization.
Review Pharmacology & Pharmacy

Purinergic signaling in diabetes and metabolism

Shanu Jain et al.

Summary: Purinergic signaling, originally proposed by Geoffrey Burnstock, plays a crucial role in modulating pathways in various physiological systems. Adenosine receptors and P2 nucleotide receptors are involved in metabolic disorders, affecting specific cell types like adipocytes, skeletal muscle, liver cells, and immune cells. Selective ligands for adenosine and P2 receptors may have therapeutic potential for diabetes and obesity, but conflicting conclusions exist in drug discovery related to this topic.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Medicine, Research & Experimental

Crosstalk of hypothalamic chemerin, histamine, and AMPK in diet-and olanzapine-induced obesity in rats

Doaa M. Samy et al.

Summary: The study reveals the complex role of chemerin in appetite regulation, with uncertainty surrounding its mechanism and relationship with histamine and AMPK. New findings suggest that neurobiochemical pathways play a crucial role in appetite and obesity regulation, highlighting the importance of further research on chemerin for clinical implications.

LIFE SCIENCES (2021)

Review Physiology

What is the physiological role of hypothalamic tanycytes in metabolism?

Matei Bolborea et al.

Summary: Tanycytes, peculiar cells in the metabolic hypothalamus, play a multifunctional role in controlling energy balance. Their physiological function in maintaining metabolic homeostasis is still unclear, leading to ambiguity in the field and providing new research directions. Furthermore, the potential involvement of tanycytes in metabolic disorders and age-related neurodegenerative diseases will be discussed.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2021)

Review Biochemistry & Molecular Biology

Extracellular vesicles and intercellular communication in the central nervous system

Lorena R. Lizarraga-Valderrama et al.

Summary: Neurons and glial cells release EVs to the interstitial fluid of the CNS, containing proteins, nucleic acids, and lipids that modulate the behavior of recipient cells. The mechanisms of EV-mediated neuron-glial communication under physiological conditions or healthy aging are not yet clear, but proteomic studies suggest potential for targeted therapies against debilitating neurological disorders.

FEBS LETTERS (2021)

Article Endocrinology & Metabolism

Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Antoine Rohrbach et al.

Summary: This study investigated the role of GCK-expressing tanycytes in the regulation of energy balance in mice. The results showed that Gck deletion induced the death of tanycytes and affected adiposity in mice, as well as NPY neuron function.

MOLECULAR METABOLISM (2021)

Article Neurosciences

Clathrin packets move in slow axonal transport and deliver functional payloads to synapses

Archan Ganguly et al.

Summary: Clathrin in neurons forms stable transport packets in axons, moving intermittently on microtubules, and at synapses, multiple clathrin packets abut synaptic vesicle clusters and exchange between synaptic boutons in a microtubule-dependent superpool.

NEURON (2021)

Review Biochemistry & Molecular Biology

Purinergic signaling in tanycytes and its contribution to nutritional sensing

Magdiel Salgado et al.

Summary: Tanycytes are hypothalamic cells that play a crucial role in regulating neuroendocrine axes and energy homeostasis. Purinergic signaling is involved in their mechanism of action, influencing satiety-controlling hypothalamic neurons' activity. Tanycytes act as nutrient sensors in the hypothalamus, with connexin hemichannels being particularly relevant in this process.

PURINERGIC SIGNALLING (2021)

Article Endocrinology & Metabolism

Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

Marta Porniece Kumar et al.

Summary: The insulin receptors in tanycytes play a critical role in regulating insulin access to the hypothalamic arcuate nucleus, impacting AgRP neuronal activity in response to feeding and contributing to obesity-associated insulin resistance. These receptors are necessary for the orexigenic effects of ghrelin and affect systemic insulin sensitivity. Compared to IR increment Tan mice, normal mice show better AgRP neuronal adaptations and insulin signaling.

NATURE METABOLISM (2021)

Article Medicine, Research & Experimental

Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons

Tori Lhomme et al.

Summary: Tanycytes in the hypothalamus convert brain glucose into lactate and transmit it to proopiomelanocortin neurons, driving their activity and metabolic response. This transmission relies on the formation of metabolic networks and plays a key role in regulating feeding behavior and energy metabolism.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Endocrinology & Metabolism

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function

Manon Duquenne et al.

Summary: The expression of leptin receptors in tanycytes is crucial for leptin to enter the brain and regulate peripheral lipogenesis and pancreatic beta-cell function. Tanycytic transport of leptin through LepRb-EGFR may also be important in the pathophysiology of diabetes.

NATURE METABOLISM (2021)

Article Multidisciplinary Sciences

Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies

Yelda Birinci et al.

SCIENTIFIC REPORTS (2020)

Article Endocrinology & Metabolism

NF-κB signaling in tanycytes mediates inflammation-induced anorexia

Mareike Boettcher et al.

MOLECULAR METABOLISM (2020)

Article Medicine, Research & Experimental

FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress

Kai Kang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Editorial Material Physiology

A special issue on glucose transporters in health and disease

Hermann Koepsell et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2020)

Article Multidisciplinary Sciences

Hypothalamic tanycytes generate acute hyperphagia activation of the arcuate neuronal network

Matei Bolborea et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Endocrinology & Metabolism

Tanycytes: A rich morphological history to underpin future molecular and physiological investigations

Esteban Rodriguez et al.

JOURNAL OF NEUROENDOCRINOLOGY (2019)

Article Neurosciences

Tanycyte-Independent Control of Hypothalamic Leptin Signaling

Sooyeon Yoo et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Neurosciences

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Cristina Garcia-Caceres et al.

NATURE NEUROSCIENCE (2019)

Article Endocrinology & Metabolism

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

Vincent Prevot et al.

ENDOCRINE REVIEWS (2018)

Article Cell Biology

A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

Scott W. Messenger et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Neurosciences

Costorage of High Molecular Weight Neurotransmitters in Large Dense Core Vesicles of Mammalian Neurons

Adalberto Merighi

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Neurosciences

Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network

Antonia Recabal et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Review Medicine, Research & Experimental

Hypothalamic inflammation in obesity and metabolic disease

Alexander Jais et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Multidisciplinary Sciences

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

Yalin Zhang et al.

NATURE (2017)

Article Multidisciplinary Sciences

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis

Helge Mueller-Fielitz et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

MicroRNA exocytosis by large dense-core vesicle fusion

Alican Gumurdu et al.

SCIENTIFIC REPORTS (2017)

Article Endocrinology & Metabolism

Amino acid sensing in hypothalamic tanycytes via umami taste receptors

Greta Lazutkaite et al.

MOLECULAR METABOLISM (2017)

Review Endocrinology & Metabolism

MicroRNA exocytosis by vesicle Fusion in Neuroendocrine Cells

Yongsoo Park

FRONTIERS IN ENDOCRINOLOGY (2017)

Article Multidisciplinary Sciences

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior

Romina Maria Uranga et al.

SCIENTIFIC REPORTS (2017)

Article Cell Biology

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

Katharina Timper et al.

DISEASE MODELS & MECHANISMS (2017)

Review Neurosciences

Extracellular vesicles round off communication in the nervous system

Vivian Budnik et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Review Biochemistry & Molecular Biology

Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism

Eun Roh et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Review Biochemistry & Molecular Biology

Network of hypothalamic neurons that control appetite

Jong-Woo Sohn

BMB REPORTS (2015)

Article Biochemistry & Molecular Biology

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons

Sophie M. Steculorum et al.

Article Endocrinology & Metabolism

Dual signal transduction pathways activated by TSH receptors in rat primary tanycyte cultures

Matei Bolborea et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2015)

Review Endocrinology & Metabolism

Hypothalamic innate immune reaction in obesity

Stefanie Kaelin et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin

Gustav Collden et al.

MOLECULAR METABOLISM (2015)

Article Cell Biology

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

Eglantine Balland et al.

CELL METABOLISM (2014)

Article Endocrinology & Metabolism

Tanycytes: A Gateway to the Metabolic Hypothalamus

F. Langlet

JOURNAL OF NEUROENDOCRINOLOGY (2014)

Article Endocrinology & Metabolism

Gliotransmission and Brain Glucose Sensing Critical Role of Endozepines

Damien Lanfray et al.

DIABETES (2013)

Review Endocrinology & Metabolism

Towards an integrative approach to understanding the role of chemerin in human health and disease

J. L. Rourke et al.

OBESITY REVIEWS (2013)

Review Endocrinology & Metabolism

Brain regulation of energy balance and body weight

Liangyou Rui

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2013)

Review Neurosciences

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

Matei Bolborea et al.

TRENDS IN NEUROSCIENCES (2013)

Article Medicine, Research & Experimental

Obesity is associated with hypothalamic injury in rodents and humans

Joshua P. Thaler et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Endocrinology & Metabolism

High calorie diet triggers hypothalamic angiopathy

Chun-Xia Yi et al.

MOLECULAR METABOLISM (2012)

Review Immunology

Inflammatory Mechanisms in Obesity

Margaret F. Gregor et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

Article Neurosciences

ATP-mediated glucosensing by hypothalamic tanycytes

Cameron Frayling et al.

JOURNAL OF PHYSIOLOGY-LONDON (2011)

Article Cell Biology

Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells

Helmuth A. Sanchez et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)

Article Biochemistry & Molecular Biology

Calcium signaling stimulates translation of HIF-α during hypoxia

Anna S. Hui et al.

FASEB JOURNAL (2006)

Article Cell Biology

Polarized endocytosis and transcytosis in the hypothalamic tanycytes of the rat

B Peruzzo et al.

CELL AND TISSUE RESEARCH (2004)

Article Endocrinology & Metabolism

Third ventricular alloxan reversibly impairs glucose counterregulatory responses

NM Sanders et al.

DIABETES (2004)

Article Neurosciences

Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain

N Braun et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2003)

Review Cell Biology

Clathrin-mediated endocytosis: membrane factors pull the trigger

K Takei et al.

TRENDS IN CELL BIOLOGY (2001)

Letter Neurosciences

Volume transmission

JL Ridet et al.

TRENDS IN NEUROSCIENCES (2000)