Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State br

After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that myosin molecules are essential for striated muscle contraction. However, this is just the tip of the iceberg of their function. Interestingly, it has been shown recently that these molecules (especially myosin heavy chains) are also crucial for cardiac and skeletal muscle testing state. In the present review, we first overview myosin heavy chain biochemical states and how they influence the consumption of ATP. We then detail how neighboring partner proteins including myosin light chains and myosin binding protein C intervene in such processes, modulat- ing the ATP demand in health and disease. Finally, we present current ex- perimental drugs targeting myosin ATP Consumption and how they can treat muscle diseases.

Automated summary

After extensive research, it is clear that myosin molecules play a vital role in muscle contraction. However, they also have important functions in cardiac and skeletal muscle. This review provides an overview of myosin heavy chain states and their influence on ATP consumption, as well as the involvement of partner proteins in modulating ATP demand. It also discusses experimental drugs targeting myosin ATP consumption for the treatment of muscle diseases.