A study of laser dose in photodynamic therapy with talaporfin sodium for malignant central airway stenosis

Photodynamic therapy (PDT) has been shown to be effective and safe in the treatment of malignant central airway stenosis. However, the laser dose for talaporfin PDT is unclear. We herein review cases where talaporfin PDT was used to treat malignant central airway stenosis. A total of 17 lesions were treated with talaporfin PDT at laser doses of 50-150 J/cm2. Improvement of airway stenosis was observed in all cases except for 1 lesion treated with a dose of 50 J/cm2. The results show that talaporfin PDT with 100 J/cm2 of laser dose is a feasible treatment for malignant central airway stenosis. (This is a secondary publication from the Journal of Japan Society for Laser Surgery and Medicine 2022; 43(1): 9-12.)

Automated summary

Photodynamic therapy (PDT) has been proven effective and safe in treating malignant central airway stenosis. However, the appropriate laser dose for talaporfin PDT remains unclear. This review of cases treated with talaporfin PDT suggests that a laser dose of 100 J/cm2 is feasible for improving airway stenosis in malignant central airway stenosis.