Journal
PHARMACOLOGICAL RESEARCH
Volume 188, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2023.106672
Keywords
Mitochondrial fission; Mitochondrial fusion; Apoptosis; Herbal medicine; Dynamin-related protein 1; Fission inhibitors; Free radical production; Natural compound
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Mitochondria are dynamic organelles that undergo fission and fusion processes to regulate their integrity and bioenergetics. Excessive mitochondrial fission can lead to structural changes, dysfunction, and cell damage. Accumulating evidence shows that mitochondrial dynamics play a role in neurodegenerative and cardiovascular diseases, as well as other diseases.
Mitochondria are morphologically dynamic organelles frequently undergoing fission and fusion processes that regulate mitochondrial integrity and bioenergetics. These processes are considered critical for cell survival. The mitochondrial fission process regulates mitochondrial biogenesis and mitophagy. It is associated with apoptosis, while mitochondrial fusion controls the accurate distribution of mitochondrial DNA and metabolic substances across the mitochondria. Excessive mitochondrial fission results in mitochondrial structural changes, dysfunction, and cell damage. Accumulating evidence demonstrates that mitochondrial dynamics affect neurodegenerative and cardiovascular diseases along with several other diseases. Biological molecules regulating the process of mitochondrial fission are potential targets for developing therapeutic agents. Many natural products target the dynamin-related protein 1 (Drp1)-dependent mitochondrial fission pathway, and their inhibitory effects ameliorate mitochondrial fragmentation. In this article, we reviewed the research literature that describes Drp1-dependent inhibition as a mechanism for the protective effects of natural compounds.
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