4.7 Review

The NLRP3 inflammasome in depression: Potential mechanisms and therapies

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Innate immunity receptors in depression and suicide: upregulated NOD-like receptors containing pyrin (NLRPs) and hyperactive inflammasomes in the postmortem brains of people who were depressed and died by suicide

Ghanshyam N. Pandey et al.

Summary: Abnormalities in inflammation, especially in innate immunity receptors such as NLRPs and their inflammasomes, were observed in the brains of people who were depressed and died by suicide. The upregulation of NLRP1, NLRP3, NLRP6, caspase3, and ASC in this population suggests a potential role of innate immunity receptors in the pathophysiology of depression and suicide.

JOURNAL OF PSYCHIATRY & NEUROSCIENCE (2021)

Article Health Care Sciences & Services

Safflower extract improves depression in mice by inhibiting the TLR4-NLRP3 inflammation signaling pathway

Haofan Chen et al.

Summary: The study demonstrated the potential antidepressant effects of safflower extract in CUMS mice, possibly through its impact on inflammation and the TLR4-NF-kappa B-NLRP3 signaling pathway in the brain.

ANNALS OF PALLIATIVE MEDICINE (2021)

Article Neurosciences

Stress increases blood beta-hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model

Tsuyoshi Nishiguchi et al.

Summary: The study aimed to assess the impact of endogenous beta-hydroxybutyrate on response to psychological stress, and its association with NLRP3 inflammasome and stress-induced behavior. Results showed that 1-hour restraint stress increased beta-hydroxybutyrate levels in blood and active NLRP3 levels in the prefrontal cortex. Mice exposed to social defeat stress displayed depression- and anxiety-like behaviors, with a correlation between these behaviors and beta-hydroxybutyrate levels.

NEUROPSYCHOPHARMACOLOGY REPORTS (2021)

Review Psychology, Clinical

The gut microbiota in anxiety and depression - A systematic review

Carra A. Simpson et al.

Summary: The gut microbiota is associated with anxiety and depressive disorders, with inconsistent findings in diversity but potential links to peripheral inflammation influencing the brain's pathophysiology. Future research should consider confounders like diet and medications, and investigate microorganism function.

CLINICAL PSYCHOLOGY REVIEW (2021)

Article Biochemistry & Molecular Biology

The Association of Major Depressive Disorder with Activation of NLRP3 Inflammasome, Lipid Peroxidation, and Total Antioxidant Capacity

Abdolghader Taene et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2020)

Article Biochemistry & Molecular Biology

Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP

Qian-Qian Cui et al.

EMBO REPORTS (2020)

Article Biochemistry & Molecular Biology

Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation

Yue Tong et al.

ACS CHEMICAL NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes

Danwen Wang et al.

CELL AND BIOSCIENCE (2020)

Article Immunology

Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression

Qingyu Zhang et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

Article Biochemistry & Molecular Biology

Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats

Feng Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Immunology

Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

Yuan Dong et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Article Neurosciences

Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome

Xiangliang Zeng et al.

NEUROTOXICITY RESEARCH (2020)

Review Immunology

Interplay Between NLRP3 Inflammasome and Autophagy

Monika Biasizzo et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression

Lin Li et al.

ACS CHEMICAL NEUROSCIENCE (2020)

Article Clinical Neurology

Linking peripheral IL-6, IL-1β and hypocretin-1 with cognitive impairment from major depression

Kangyu Jin et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

Review Psychiatry

Curcumin in Depression: Potential Mechanisms of Action and Current Evidence-A Narrative Review

Tahiana Ramaholimihaso et al.

FRONTIERS IN PSYCHIATRY (2020)

Review Endocrinology & Metabolism

Toll-Like Receptor Signaling in Depression

Leandra K. Figueroa-Hall et al.

PSYCHONEUROENDOCRINOLOGY (2020)

Article Biochemistry & Molecular Biology

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

Chun-Yan Wang et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Biochemistry & Molecular Biology

lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation

Zhenyi Xue et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Biochemistry & Molecular Biology

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

Jaye M. Platnich et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

Review Pharmacology & Pharmacy

Sex differences in the hypothalamic-pituitary-adrenal axis: An obstacle to antidepressant drug development?

Nikolaos Kokras et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Engineering, Environmental

Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation

Chen Chu et al.

JOURNAL OF HAZARDOUS MATERIALS (2019)

Article Biochemistry & Molecular Biology

MCC950 directly targets the NLRP3 ATP- hydrolysis motif for inflammasome inhibition

Rebecca C. Coll et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Medicine, General & Internal

Increased levels of plasma IL-1b and BDNF can predict resistant depression patients

Luciana Uint et al.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2019)

Article Neurosciences

Predictable chronic mild stress promotes recovery from LPS-induced depression

Ruili Dang et al.

MOLECULAR BRAIN (2019)

Review Biochemistry & Molecular Biology

P2X7 Receptor Signaling in Stress and Depression

Deidiane Elisa Ribeiro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

Review Immunology

Pharmacological Inhibitors of the NLRP3 Inflammasome

Ayesha Zahid et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors

Seung Yeon Ko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Immunology

Depression and sterile inflammation: Essential role of danger associated molecular patterns

Tina C. Franklin et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

Review Neurosciences

NLRs as Helpline in the Brain: Mechanisms and Therapeutic Implications

Shalini Singh et al.

MOLECULAR NEUROBIOLOGY (2018)

Review Cell Biology

Role and Possible Mechanisms of Sirt1 in Depression

Guofang Lu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Review Neurosciences

Inflammasome signalling in brain function and neurodegenerative disease

Michael T. Heneka et al.

NATURE REVIEWS NEUROSCIENCE (2018)

Article Endocrinology & Metabolism

Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders

Anindya Bhattacharya et al.

PSYCHONEUROENDOCRINOLOGY (2018)

Review Neurosciences

Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases

Bo-Zong Shao et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice

Tianyuan Ye et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Medicine, Research & Experimental

Anti-Depressant-Like Effect of Sinomenine on Chronic Unpredictable Mild Stress-Induced Depression in a Mouse Model

Shengbing Liu et al.

MEDICAL SCIENCE MONITOR (2018)

Review Immunology

Spotlight on the NLRP3 inflammasome pathway

Marine Groslambert et al.

JOURNAL OF INFLAMMATION RESEARCH (2018)

Article Immunology

Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress

Ya-Min Liu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

Article Clinical Neurology

NLRP3 Inflammasome Contributes to Lipopolysaccharide-induced Depressive-Like Behaviors via Indoleamine 2,3-dioxygenase Induction

Seon-A Jeon et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2017)

Article Pharmacology & Pharmacy

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

Elisabet Alcocer-Gomez et al.

PHARMACOLOGICAL RESEARCH (2017)

Article Multidisciplinary Sciences

Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice

Frances M. Munoz et al.

SCIENTIFIC REPORTS (2017)

Article Cell Biology

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagydependent manner

Marianne R. Spalinger et al.

AUTOPHAGY (2017)

Article Neurosciences

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

Elisabet Alcocer-Gomez et al.

MOLECULAR NEUROBIOLOGY (2016)

Article Pharmacology & Pharmacy

Agmatine Reverses Sub-chronic Stress induced Nod-like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats

Ceren Sahin et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2016)

Article Neurosciences

Mitochondrial Dysfunction in Depression

Yashika Bansal et al.

CURRENT NEUROPHARMACOLOGY (2016)

Article Clinical Neurology

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression

Ren-Hong Du et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2016)

Article Clinical Neurology

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

Yi Zhang et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Yun-Hee Youm et al.

NATURE MEDICINE (2015)

Article Psychology, Biological

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

Xue-Yang Deng et al.

PHYSIOLOGY & BEHAVIOR (2015)

Article Endocrinology & Metabolism

Mitochondrial UCP2 in the central regulation of metabolism

Chitoku Toda et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Immunology

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

Elisabet Alcocer-Gomez et al.

BRAIN BEHAVIOR AND IMMUNITY (2014)

Review Pharmacology & Pharmacy

Transient receptor potential ( TRP) channels: a clinical perspective

Yosuke Kaneko et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Psychiatry

The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals

Batool Hajebrahimi et al.

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE (2014)

Article Clinical Neurology

Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies

Maree L. Hackett et al.

INTERNATIONAL JOURNAL OF STROKE (2014)

Article Psychiatry

Toll-like receptors in the depressed and suicide brain

Ghanshyam N. Pandey et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2014)

Article Psychiatry

Association between toll-like receptors expression and major depressive disorder

Yi-Yung Hung et al.

PSYCHIATRY RESEARCH (2014)

Article Biochemistry & Molecular Biology

Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

Yue Fu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Biochemistry & Molecular Biology

Astrocyte-derived ATP modulates depressive-like behaviors

Xiong Cao et al.

NATURE MEDICINE (2013)

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

Kentaro Nishida et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Multidisciplinary Sciences

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Geun-Shik Lee et al.

NATURE (2012)

Article Multidisciplinary Sciences

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

Tomohiko Murakami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

R. C. Shelton et al.

MOLECULAR PSYCHIATRY (2011)

Article Geriatrics & Gerontology

Interleukin-1β Serum Levels is Increased in Antidepressant-Free Elderly Depressed Patients

Breno Satler Diniz et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2010)

Review Immunology

Depression and immunity: A role for T cells?

Andrew H. Miller

BRAIN BEHAVIOR AND IMMUNITY (2010)

Article Biochemistry & Molecular Biology

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

M. Tfilin et al.

MOLECULAR PSYCHIATRY (2010)

Review Cardiac & Cardiovascular Systems

Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

Ling Gao et al.

CARDIOVASCULAR RESEARCH (2009)

Review Biochemistry & Molecular Biology

Cell signaling via the P2X7 nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking

Lisa Y. Lenertz et al.

PURINERGIC SIGNALLING (2009)

Review Neurosciences

Interleukin-18 and stress

Shuei Sugama et al.

BRAIN RESEARCH REVIEWS (2008)

Article Physiology

The P2X7 Receptor Channel Pore Dilates under Physiological Ion Conditions

Zonghe Yan et al.

JOURNAL OF GENERAL PHYSIOLOGY (2008)

Article Cell Biology

Interleukin-18 and CD30 serum levels in patients with moderate-severe depression

RA Merendino et al.

MEDIATORS OF INFLAMMATION (2002)

Article Urology & Nephrology

Depression and incontinence

WD Steers et al.

WORLD JOURNAL OF UROLOGY (2001)