Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

Article Oncology

Oxaliplatin inhibits colorectal cancer progression by inhibiting CXCL11 secreted by cancer-associated fibroblasts and the CXCR3/PI3K/AKT pathway

Caifu Lu et al.

Summary: This study found that Oxaliplatin inhibited the progression of colorectal cancer (CRC) by suppressing CAFs-secreted CXCL11 and the CXCR3/PI3K/AKT signaling pathway.

CLINICAL & TRANSLATIONAL ONCOLOGY (2023)

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Review Biochemistry & Molecular Biology

Autophagy as a molecular target of quercetin underlying its protective effects in human diseases

Milad Ashrafizadeh et al.

Summary: Autophagy is a self-eating process that degrades aged or damaged components and organelles. It plays a crucial role in physiological conditions and neurological disorders. Quercetin, a plant-derived chemical, has various biological and therapeutic effects. This review provides an overview of the relationship between quercetin and autophagy, as well as how quercetin modulates the autophagy mechanism.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

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Article Oncology

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

Srimanta Patra et al.

Summary: Autophagy is a self-degradation process that eliminates dysfunctional cytoplasmic cargos to maintain cellular homeostasis. It plays a dual role in cytoprotection and cytostasis during malignant transformation, and is regulated by phyto-products. Autophagy also regulates epigenetic modulation and inflammation, limiting tumor metastasis.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Oncology

Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds

Zhaowu Ma et al.

Summary: Rapid progress in molecular cancer biology and the discovery of new oncology drugs have opened new opportunities for cancer target discovery. HIF-1, a crucial signaling pathway related to tumorigenesis, regulates the activity of many transcription factors and downstream molecules that affect tumor growth and metastasis. Overexpression of HIF-1 alpha is strongly associated with poor prognosis in several solid cancers. Pharmacological targeting of the HIF-1 signaling pathway has been considered a new strategy for cancer therapy, but translation into clinically available treatments remains challenging.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity

Bin Zhang et al.

Summary: CTR9, a scaffold protein of the PAF1 complex, plays essential roles in hepatocellular carcinoma by promoting cell proliferation, invasion, and migration. CTR9 also promotes HCC development by enhancing the transcription of the oncogene PEG10. Targeting CTR9 may provide a novel therapeutic strategy for HCC.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Oncology

CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma

Jia Li et al.

Summary: This study reveals that circRPN2 can suppress the metastasis of hepatocellular carcinoma by accelerating the degradation of ENO1 and regulating the miR-183-5p/FOXO1 axis to inhibit glycolysis and tumor progression. Additionally, the expression level of circRPN2 can serve as a novel indicator for HCC prognosis.

CANCER RESEARCH (2022)

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Article Gastroenterology & Hepatology

PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells

Laura Rosa Mangiapane et al.

Summary: In colorectal cancer stem cells, high HER2 expression levels are associated with activation of the PI3K/AKT pathway. The targeting of HER2 in combination with PI3K and MEK inhibitors induces CR-CSC death and regression of tumor xenografts, including those with specific mutations. Triple targeting of PI3K, HER2, and MEK is necessary to overcome resistance to anti-EGFR therapies.

GUT (2022)

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Article Oncology

VLCAD inhibits the proliferation and invasion of hepatocellular cancer cells through regulating PI3K/AKT axis

Q. W. Zhu et al.

Summary: The expression of VLCAD is downregulated in human HCC tissues and cells. VLCAD overexpression can suppress the proliferation and metastasis of HCC cells by inhibiting the activities of glycolysis and mitochondrial oxidative phosphorylation metabolism through the PI3K/AKT pathway.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

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Review Pharmacology & Pharmacy

Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects

Sepideh Mirzaei et al.

Summary: In this review, the molecular pathways regulating P-gp and its involvement in DOX resistance are highlighted. The development of nanocarriers for co-delivery of DOX with anticancer compounds and genes is also discussed. Furthermore, the surface modification of nanocarriers to enhance selectivity towards cancer cells is explored.

DRUG DISCOVERY TODAY (2022)

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Article Biochemistry & Molecular Biology

Echinacea purpurea suppresses the cell survival and metastasis of hepatocellular carcinoma through regulating the PI3K/Akt pathway

Wenqian Xu et al.

Summary: Echinacea purpurea shows potential preventive effects on hepatocellular carcinoma through regulating the PI3K/Akt pathway, which can ameliorate tumor cell survival and migration.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2022)

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Article Oncology

Ophiopogonin-B targets PTP1B to inhibit the malignant progression of hepatocellular carcinoma by regulating the PI3K/AKT and AMPK signaling pathways

Fang Yuan et al.

Summary: This study revealed the inhibitory effect of OP-B on hepatocellular carcinoma (HCC) and its mechanism. OP-B inhibited HCC progression by downregulating PTP1B expression, thus inactivating the PI3K/AKT pathway and activating the AMPK pathway, leading to the suppression of HCC growth, proliferation, invasion, and angiogenesis.

MOLECULAR MEDICINE REPORTS (2022)

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Article Chemistry, Medicinal

Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis

Linlin Wang et al.

Summary: Alnustone exhibits potent growth inhibition against hepatocellular carcinoma (HCC) by inducing apoptosis and inhibiting the PI3K/Akt/mTOR/p70S6K pathway.

PHYTOTHERAPY RESEARCH (2022)

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Article Gastroenterology & Hepatology

Patterns, treatments, and prognosis of tumor recurrence after resection for hepatocellular carcinoma with microvascular invasion: a multicenter study from China

Zhen-Hua Chen et al.

Summary: This study analyzed the post-hepatectomy tumor recurrence in patients with hepatocellular carcinoma (HCC) and microvascular invasion (MVI). The results showed that early recurrence and intrahepatic-only recurrence had worse prognosis. Repeat resection with curative intent showed better outcomes than other treatment modalities.

HPB (2022)

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Review Medicine, Research & Experimental

The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy

Juan Li et al.

Summary: Exosomal circRNAs play important regulatory roles in cancer, especially in the tumor microenvironment. They can influence tumor development and propagation, as well as important processes such as tumor immunity, metabolism, angiogenesis, drug resistance, epithelial mesenchymal transition, invasion, and metastasis.

THERANOSTICS (2022)

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Article Health Care Sciences & Services

MicroRNA-517c Functions as a Tumor Suppressor in Hepatocellular Carcinoma via Downregulation of KPNA2 and Inhibition of PI3K/AKT Pathway

Limin Ma et al.

Summary: This study demonstrates that decreased expression of miR-517c in HCC tissues and cells is associated with poor prognosis, and upregulation of miR-517c inhibits HCC cell proliferation, invasion, and migration. MiR-517c directly targets KPNA2 and regulates the PI3K/AKT pathway and EMT, showing potential as a novel therapeutic target for HCC treatment.

JOURNAL OF HEALTHCARE ENGINEERING (2022)

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Article Oncology

PAK3 promotes the metastasis of hepatocellular carcinoma by regulating EMT process

Zhi Gao et al.

Summary: This study found that PAK3 is highly expressed in HCC patients and is positively correlated with tumor stage and grade. PAK3 promotes the proliferation, migration, and invasion of HCC cells and regulates EMT-related molecules and pathways. Therefore, PAK3 may be a potential therapeutic target for HCC.

JOURNAL OF CANCER (2022)

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Review Cell Biology

Epithelial Mesenchymal Transition (EMT) and Associated Invasive Adhesions in Solid and Haematological Tumours

David Greaves et al.

Summary: In solid tumors, EMT plays a crucial role in promoting invasive migration and drug resistance, while its association with poor prognosis in hematological tumors is still under investigation. Understanding the connection between EMT and specific types of adhesions in hematological malignancies may lead to new therapeutic interventions to overcome disease progression and resistance to therapies.

CELLS (2022)

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Article Medicine, Research & Experimental

Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC

Eric Tu et al.

Summary: Anti-PD-1 and anti-PD-L1 therapies are effective in non-small cell lung cancer (NSCLC), but less so in patients with EGFR mutations. This study found that EGFR-mutated NSCLC expressed higher levels of CD73 and were more resistant to T cell killing. Combining anti-PD-L1 and anti-CD73 therapies significantly inhibited tumor growth and increased T cell activity in EGFR-mutated NSCLC. These findings support the use of combination therapy in this patient population.

JCI INSIGHT (2022)

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Article Chemistry, Medicinal

Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

Renjing Yang et al.

Summary: This study investigated the structural modification and optimization of U12, a derivative of UDCA, and synthesized twelve U12 derivatives. The evaluation of their cytotoxicity against hepatoma cell lines showed that U12a had the most potent anti-hepatocellular carcinoma activity. Mechanism studies revealed that U12a inhibited cell proliferation and induced apoptosis through the caspase signaling pathway. In vivo experiments demonstrated that U12a effectively inhibited tumor growth without observable adverse effects. Overall, U12a showed promising potential for the treatment of hepatocellular carcinoma.

PHARMACEUTICALS (2022)

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Article Biology

3-Formylchromone Counteracts STAT3 Signaling Pathway by Elevating SHP-2 Expression in Hepatocellular Carcinoma

Chakrabhavi Dhananjaya Mohan et al.

Summary: This study demonstrates that 3-formylchromone inhibits the activated STAT3 signaling in hepatocellular carcinoma cells and effectively reduces tumor growth and metastasis in a mouse model. The researchers also found that 3-formylchromone does not cause substantial toxicity. Therefore, it has the potential to be a powerful agent for targeting STAT3 signaling in hepatocellular carcinoma.

BIOLOGY-BASEL (2022)

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Article Biochemistry & Molecular Biology

MicroRNA-148a Inhibits Hepatocellular Carcinoma Cell Growth via Epithelial-to-Mesenchymal Transition and PI3K/AKT Signaling Pathways by Targeting Death Receptor-5

Naipeng Zhang et al.

Summary: This study found that miR-148a plays a role in inhibiting cell proliferation, migration, and invasion in HCC. This function is achieved through regulating the EMT and PI3K/AKT signaling pathways. The expression level of miR-148a is positively correlated with the survival time and prognosis of HCC patients.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy

Mahshid Deldar Abad Paskeh et al.

Summary: Autophagy plays a dual role in normal cells and tumors, and targeting autophagy using nanoparticles can enhance cancer therapy. Nanocarriers can deliver autophagy regulators and chemotherapeutic agents, while nanomaterials can affect key components of autophagy.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

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Article Pharmacology & Pharmacy

PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An <i>in Vitro</i> and <i>in Vivo</i> Study

Yan Luo et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2022)

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Article Oncology

Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells

Kubra Narci et al.

Summary: This study investigated the differential effects of isoform specific PI3K inhibitors in combination with Sorafenib on liver cancer cells, demonstrating distinct consequences of PIK-75 and TGX-221 in different cellular contexts. The analysis using PCST revealed the mechanisms behind these differences, highlighting the importance of context dependent and isoform specific PI3K/Akt/mTOR signaling inhibition in drug resistance during combination therapies.

BMC CANCER (2022)

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Article Oncology

MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway

Wei Su et al.

Summary: MUC3A promotes the progression of colorectal cancer by activating the PI3K/Akt/mTOR signaling pathway and affects cell proliferation, invasion, and chemotherapy resistance. This study reveals the important role of MUC3A in colorectal cancer.

BMC CANCER (2022)

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Article Oncology

YTHDF1 amplification is correlated with worse outcome and lower immune cell infiltrations in breast cancer

Cheukfai Li et al.

Summary: This study demonstrates that amplification of YTHDF1 is associated with poor clinical characteristics and survival outcomes in breast cancer. YTHDF1 amplification may be involved in MYC signaling regulation and T cell differentiation, and it may result in reduced immune cell infiltration.

CANCER BIOMARKERS (2022)

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Article Oncology

Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5c

Yi-ming Li et al.

Summary: Piezo1 is upregulated in hepatocellular carcinoma (HCC) and is closely associated with clinicopathological features and poor prognosis. Knockdown of Piezo1 inhibits proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells, as well as tumor growth and metastasis. Piezo1 promotes HCC progression through activating the TGF-beta signaling pathway.

CANCER CELL INTERNATIONAL (2022)

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Review Oncology

Role of EMT in the DNA damage response, double-strand break repair pathway choice and its implications in cancer treatment

Caroline Moyret-Lalle et al.

Summary: EMT is involved in tumor development and DNA repair. Understanding the role of EMT in DNA repair can lead to new treatments targeting tumors and improving efficacy.

CANCER SCIENCE (2022)

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Article Cell Biology

MiR-1306-5p predicts favorable prognosis and inhibits proliferation, migration, and invasion of colorectal cancer cells via PI3K/AKT/mTOR pathway

Wei Wang et al.

Summary: MiR-1306-5p is found to be downregulated in colorectal cancer, and its overexpression inhibits cell proliferation, migration, and invasion, while promoting apoptosis. SLCO2A1 is identified as a target gene of miR-1306-5p, and overexpression of miR-1306-5p can inhibit the PI3K/AKT/mTOR signaling pathway by targeting SLCO2A1. Therefore, miR-1306-5p may serve as a potential therapeutic target for treating colorectal cancer.

CELL CYCLE (2022)

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Review Pharmacology & Pharmacy

Possible involvement of apoptosis in the antipsychotics side effects: A mini-review

Jana Osacka et al.

Summary: Antipsychotics are commonly used in the treatment of psychiatric disorders such as schizophrenia. They have various pharmacological effects and can induce both desirable and undesirable consequences, including neurotoxicity and potential harm to fetal brains. Some antipsychotics have shown apoptotic effects on cancer cells, suggesting their potential use in cancer treatment.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2022)

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Review Oncology

Epigenetic modification regulates tumor progression and metastasis through EMT (Review)

Tingshan Tan et al.

Summary: Epigenetics is the study of heritable factors that are independent of phenotypic features, including DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling. In tumor progression and metastasis, epigenetic changes play a crucial role in cellular differentiation, function, and the process of epithelial-mesenchymal transition (EMT). Understanding the role of epigenetics in EMT not only enhances our understanding of cancer progression and spread, but also provides new opportunities for diagnosing and treating human malignancy in the clinical setting.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Review Oncology

An emerging role of radiation-induced exosomes in hepatocellular carcinoma progression and radioresistance (Review)

Qing Fan et al.

Summary: The incidence rates of hepatocellular carcinoma (HCC) worldwide are increasing, and the role of radiotherapy is currently under discussion. Radioresistance is one of the most important challenges in the therapy of HCC compared with other local advanced, recurrent and metastatic cancers. Exosomes, which are 40- to 150-nm extracellular vesicles released by cancer cells, have been found to play critical functions in cancer progression and are potentially involved in radioresistance. Understanding the roles and mechanisms of exosomes in HCC progression and radiation response during HCC therapy may lead to novel approaches for HCC prognosis and treatment.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Article Cell Biology

ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3β/Snail pathway driven by TGFβ/Smad signals

Yinci Zhang et al.

Summary: ASIC1a is overexpressed in hepatocellular carcinoma (HCC) and closely associated with cell migration, invasion, and drug resistance. Inactivation of ASIC1a can inhibit cell migration and invasion and increase chemosensitivity. ASIC1a promotes cell migration and invasion through the regulation of multiple signaling pathways and related proteins via upregulating EMT.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Review Cell Biology

NF-kappa B as a regulator of cancer metastasis and therapy response: A focus on epithelial-mesenchymal transition

Sepideh Mirzaei et al.

Summary: Metastasis of tumor cells is a significant challenge in cancer patients, and the activation of nuclear factor-kappaB (NF-kappa B) plays a crucial role in regulating the epithelial-to-mesenchymal transition (EMT). The activation of NF-kappa B enhances the invasive properties of tumor cells through inducing EMT mechanism, and this has been confirmed in various cancers.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Oncology

EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway

Yachong Liu et al.

Summary: In this study, it was found that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Oncology

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

Milad Ashrafizadeh et al.

Summary: This review discusses the role and regulatory mechanisms of autophagy in prostate cancer. Autophagy can impact cancer cell proliferation, survival, and metastasis, as well as the response to therapy. Targeting autophagic genes and utilizing nanotherapeutics show promise in improving patient prognosis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Oncology

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Qinghua Wu et al.

Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Letter Oncology

Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting immunostimulatory tumor microenvironment

Shuangshuang Yin et al.

Summary: This study demonstrates that solamargine (SM) inhibits the proliferation of hepatocellular carcinoma (HCC) and induces HCC cell apoptosis and autophagy in vitro and in vivo. It exerts its anti-tumor effects through the LIF/miR-192-5p/CYR61/Akt signaling pathways and also affects tumor-associated macrophages and other immune cell populations in the HCC microenvironment.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Medicine, Research & Experimental

Daidzin targets epithelial-to-mesenchymal transition process by attenuating manganese superoxide dismutase expression and PI3K/Akt/mTOR activation in tumor cells

Min Hee Yang et al.

Summary: DDZ regulates MnSOD and EMT process by targeting PI3K/Akt/mTOR pathway in colorectal and prostate cancer cell lines.

LIFE SCIENCES (2022)

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Article Cell Biology

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis

Xuemei Yao et al.

Summary: The study reveals that YTHDF1 in breast cancer acts as a driver in promoting tumor growth and metastasis by enhancing glycolysis. Tumor hypoxia induces the expression of YTHDF1 and inhibits miR-16-5p, leading to increased tumor glycolysis and tumorigenesis.

CELL DEATH & DISEASE (2022)

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Article Cell Biology

YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance

Yu Sun et al.

Summary: YTHDF1 plays a tumor-promoting role in breast cancer and is involved in DNA damage repair by modulating E2F8. Inhibition of YTHDF1 can enhance the sensitivity of breast cancer cells to chemotherapy drugs.

CELL DEATH & DISEASE (2022)

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Article Multidisciplinary Sciences

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

Zhen Ning et al.

Summary: This study reveals that USP22 stabilizes PPARgamma through deubiquitination, promoting lipid accumulation and hepatocellular carcinoma development.

NATURE COMMUNICATIONS (2022)

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Article Oncology

LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway

Huan Yue et al.

Summary: We identified a novel long non-coding RNA, Linc02154, which is highly expressed in hepatocellular carcinoma (HCC) cells and tissues and associated with poor overall survival of patients. Functional experiments demonstrated that exogenous expression of Linc02154 promoted proliferation, migration, invasion, and tumorigenesis of HCC cells both in vitro and in vivo. Mechanistically, Linc02154 enhanced the activity of the SPC24 promoter and up-regulated SPC24 expression through activation of the PI3K/AKT signaling pathway and its downstream targets, including cell cycle progression and EMT-associated gene expression.

CELLULAR ONCOLOGY (2022)

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Article Medicine, Research & Experimental

Pre-mRNA processing factor 19 functions in DNA damage repair and radioresistance by modulating cyclin D1 in hepatocellular carcinoma

Xiang-Nan Yu et al.

Summary: This study reveals the correlation between elevated expression of PRP19 and DNA damage repair in hepatocellular carcinoma (HCC). PRP19 affects the DNA damage repair ability in HCC by modulating cyclin D1 expression and function. The combination of PRP19 and cyclin D1 is valuable for predicting patient prognosis in HCC.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Oncology

CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway

Xiaojia Huang et al.

Summary: ARF6 is activated by CCL18 and mediates breast cancer metastasis through its downstream effector AMAP1. CCL18 promotes malignant behaviors in breast cancer cells by up-regulating the Src/PI3K/Akt signaling pathway through ARF6.

MOLECULAR THERAPY-ONCOLYTICS (2022)

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Article Oncology

Exosomes From Cancer-Associated Mesenchymal Stem Cells Transmit TMBIM6 to Promote the Malignant Behavior of Hepatocellular Carcinoma via Activating PI3K/AKT Pathway

Chuzhi Shang et al.

Summary: This study revealed that exosomes derived from HCC-MSCs promote malignant behavior in HCC cells by transmitting TMBIM6, which activates the PI3K/AKT pathway.

FRONTIERS IN ONCOLOGY (2022)

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Review Public, Environmental & Occupational Health

Economic Burden and Quality of Life of Hepatocellular Carcinoma in Greater China: A Systematic Review

Huimin Zou et al.

Summary: Hepatocellular carcinoma (HCC) in greater China has significant economic and quality of life burden on patients. Studies have shown that HCC causes major economic impact on patients and their families, as well as negative effects on patients' quality of life.

FRONTIERS IN PUBLIC HEALTH (2022)

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Article Biology

Leelamine Modulates STAT5 Pathway Causing Both Autophagy and Apoptosis in Chronic Myelogenous Leukemia Cells

Young Yun Jung et al.

Summary: In this study, we demonstrate that leelamine inhibits STAT5 activation and induces autophagy and apoptosis in chronic myeloid leukemia cells. This suggests that targeted inhibition of STAT5 by leelamine can enhance two distinct cell death pathways.

BIOLOGY-BASEL (2022)

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Article Multidisciplinary Sciences

Myricetin induces apoptosis and autophagy in human gastric cancer cells through inhibition of the PI3K/Akt/mTOR pathway

So-Hee Han et al.

Summary: The study found that myricetin induced apoptosis and autophagy in AGS gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway, leading to decreased cell proliferation.

HELIYON (2022)

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Article Biotechnology & Applied Microbiology

GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway

Yuen Chak Tiu et al.

Summary: This study identifies and characterizes the role of GLIPR1 in the progression of hepatocellular carcinoma (HCC), suggesting its potential as a prognostic biomarker and therapeutic target. GLIPR1 promotes tumor proliferation, metastasis, and chemoresistance in HCC through mechanisms such as inducing epithelial-mesenchymal transition (EMT) and activating the PI3K/PDK1/ROCK1 signaling axis. The findings highlight the importance of GLIPR1 and its downstream factors in HCC and have implications for the discovery of therapeutic targets and improvement of chemotherapy outcomes and prognosis.

CANCER GENE THERAPY (2022)

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Article Biochemistry & Molecular Biology

Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade

Anuradha Kirtonia et al.

Summary: LAMC2 plays a crucial role in the tumorigenesis of PDAC by repressing epithelial-mesenchymal transition and modulating the EGFR/ERK1/2/AKT/mTOR axis, thus inhibiting PDAC tumor growth and metastasis.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Review Oncology

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Mahshid Deldar Abad Paskeh et al.

Summary: This review discusses the role of exosomes in cancer progression, therapy, and regulation of the tumor microenvironment. The study found that exosomes can influence cancer cell proliferation and migration rates by modulating components of the tumor microenvironment. Depending on their cargo, exosomes can promote or suppress tumor cell progression and enhance or reduce the response to radiotherapy and chemotherapy. Additionally, exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by transferring RNA and modulating molecular signaling pathways. Moreover, exosomes can serve as carriers of anti-tumor agents and genetic tools to control cancer progression. Finally, exosomes are valuable diagnostic and prognostic tools in the treatment of cancer patients.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Integrative & Complementary Medicine

Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling axis

Wei Guo et al.

Summary: The study shows that Sinikangai decoction can inhibit the growth of hepatocellular carcinoma by interfering with the PI3K/Akt/P53/FoxO signaling pathway and promoting tumor cell apoptosis. This provides scientific evidence for Sinikangai decoction as an alternative treatment for hepatocellular carcinoma.

CHINESE MEDICINE (2022)

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Article Cell Biology

Isoimperatorin down-regulates epithelial mesenchymal transition through modulating NF-ΚB signaling and CXCR4 expression in colorectal and hepatocellular carcinoma cells

Na Young Kim et al.

Summary: This study found that IIPT derived from Angelica dahurica can potentially function as a novel anti-metastatic agent by inhibiting EMT and metastasis process via inhibition of NF-kappa B activation and CXCR4 expression.

CELLULAR SIGNALLING (2022)

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Article Engineering, Environmental

Photoactive polymers-decorated Cu-Al layered double hydroxide hexagonal architectures: A potential non-viral vector for photothermal therapy and co-delivery of DOX/pCRISPR

Milad Ashrafizadeh et al.

Summary: In this study, Cu-Al layered double hydroxide (LDH) nanoparticles decorated with different forms of poly(phenylenediamine) were fabricated and used for the co-delivery of the drug doxorubicin (DOX) and plasmid CRISPR (pCRISPR). The pH-responsive nanocarriers exhibited high drug release in an acidic environment and showed promising cargo delivery in MEF-7 and HEK-293 cells. The study also assessed the potential usage of the cell-imprinted technique to enhance cellular internalization and demonstrated the biocompatibility and anti-cancer activity of LDH nanostructures.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Oncology

Combination of ShuangDan Capsule and Sorafenib Inhibits Tumor Growth and Angiogenesis in Hepatocellular Carcinoma Via PI3K/Akt/mTORC1 Pathway

Wenbo Ding et al.

Summary: The purpose of this study was to investigate whether a Chinese patent medicine, ShuangDan Capsules (SDC), could improve the anti-cancer effect and mitigate adverse reactions of sorafenib on hepatocellular carcinoma (HCC) in vivo. The results showed that the combination of SDC and sorafenib inhibited the progression of DEN-induced HCC and exhibited greater suppression on tumor growth in the HepG2 xenografts model. Furthermore, the combination therapy inhibited the PI3K/Akt/mTORC1 pathway and remedied the hepatotoxicity caused by sorafenib monotherapy.

INTEGRATIVE CANCER THERAPIES (2022)

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Article Toxicology

Ropivacaine represses the ovarian cancer cell stemness and facilitates cell ferroptosis through inactivating the PI3K/AKT signaling pathway

Yi Lu et al.

Summary: This study found that ropivacaine has potential therapeutic effects in ovarian cancer by inhibiting cancer stemness and promoting ferroptosis through the inactivation of the PI3K/AKT signaling pathway.

HUMAN & EXPERIMENTAL TOXICOLOGY (2022)

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Review Oncology

Essential role of aerobic glycolysis in epithelial-to-mesenchymal transition during carcinogenesis

Chandra Prakash Prasad et al.

Summary: This review discusses the significance of epithelial-to-mesenchymal transition (EMT) in the metastasis and drug resistance of cancer cells, and highlights the important role of glycolytic enzymes in inducing this process.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

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Article Nanoscience & Nanotechnology

Nanoparticles Loaded with GSK1059615 Combined with Sorafenib Inhibited Programmed Cell Death 1 Ligand 1 Expression by Negatively Regulating the PI3K/Akt/NF-KB Pathway, Thereby Reversing the Drug Resistance of Hepatocellular Carcinoma to Sorafenib

Shuping Zhou et al.

Summary: This study found that GSK1059615 inhibited the proliferation and invasion of sorafenib-resistant hepatocellular carcinoma cells. By modifying nanoparticles, the drug resistance of the cells to sorafenib was reversed. These findings are important for the development of more effective treatments for resistant cancers.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2022)

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Article Medicine, General & Internal

Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway

Lu Huang et al.

Summary: In hepatocellular carcinoma, Tollip overexpression promotes tumor progression by enhancing proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of cancer cells, through the activation of the PI3K/AKT signaling pathway. Blocking the Tollip-PI3K/AKT axis may offer a potential therapeutic strategy for hepatocellular carcinoma management.

OPEN MEDICINE (2022)

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Article Oncology

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition

Xiangyuan Luo et al.

Summary: YTHDF1 is overexpressed in HCC and associated with HCC grade. It promotes the growth of HCC cells by activating the PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition (EMT) to enhance migration and invasion.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

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Article Oncology

XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner

Yi Deng et al.

Summary: XPA overexpression suppresses HCC by inducing autophagy and apoptosis, and modulating the PI3K/Akt/mTOR signaling pathway.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Plantamajoside inhibits hypoxia-induced migration and invasion of human cervical cancer cells through the NF-κB and PI3K/akt pathways

Xia Zuo et al.

Summary: Plantamajoside (PMS) inhibits the migration and invasion of cervical cancer cells under hypoxic condition by preventing hypoxia-induced EMT. The study suggests that PMS may serve as a therapeutic agent for the treatment of cervical cancer.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2021)

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Article Oncology

Fisetin Inhibits Autophagy in HepG2 Cells via PI3K/Akt/mTOR and AMPK Pathway

Kiruthika Sundarraj et al.

Summary: The study revealed that fisetin inhibits autophagy in HepG2 cells by activating the PI3K/Akt/mTOR pathway and modulating the AMPK signaling pathway, suggesting it could be an effective therapeutic strategy against hepatocellular carcinoma.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

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Article Medicine, Research & Experimental

circRNA circARNT2 Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting the miR-155-5p/PDK1 Axis

Yueyong Li et al.

Summary: Our study revealed that circARNT2 is significantly upregulated in HCC patients and can modulate cisplatin resistance through the miR-155-5p/PDK1 pathway. This suggests that circARNT2 may serve as a promising therapeutic target for overcoming cisplatin resistance in HCC.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Biochemistry & Molecular Biology

Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells

So Young Kim et al.

Summary: The study revealed that coptisine induces autophagy in HCC Hep3B cells through regulating PI3K/Akt/mTOR signaling and mitochondrial ROS production, leading to autophagic cell death and suppression of autophagosome-lysosome fusion.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

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Article Oncology

Prognostic biomarker SMARCC1 and its association with immune infiltrates in hepatocellular carcinoma

Xiaopeng Cai et al.

Summary: Epigenetic alterations, especially the overexpression of SMARCC1, play crucial roles in metastasis and dissemination of hepatocellular carcinoma. Bioinformatics analysis and wet-bench experiments revealed that high levels of SMARCC1 are associated with poor prognosis in HCC, and it influences tumor cell proliferation, migration, and invasion. Additionally, SMARCC1 expression is linked to specific transcription factors and DNA methylation levels, affecting immune infiltration and promoting tumor progression in HCC.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma

Yao An et al.

Summary: Hepatocellular carcinoma (HCC) is a prevalent and lethal cancer, lacking effective treatment. The antifungal Natamycin (NAT) has been found to exhibit antitumor activity by inducing apoptosis and promoting ubiquitination-mediated degradation of Peroxiredoxin 1 (PRDX1), resulting in increased reactive oxygen species (ROS) accumulation and decreased phosphorylation of AKT. Combinational use of NAT with chloroquine (CQ) or sorafenib (SOR) achieves better anti-tumor efficacy in HCC suppression.

CANCER LETTERS (2021)

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Review Chemistry, Applied

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Milad Ashrafizadeh et al.

Summary: Hyaluronic acid-modified nanostructures can enhance the delivery of doxorubicin to cancer cells, overcoming chemoresistance and providing a platform for the co-delivery of genes and drugs.

CARBOHYDRATE POLYMERS (2021)

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Article Oncology

GNA14's interaction with RACK1 inhibits hepatocellular carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway

Cong Xu et al.

Summary: This study revealed that decreased expression of GNA14 was associated with aggressive features in hepatocellular carcinoma (HCC), while high expression was linked to better overall and disease-free survival. GNA14 acted as a suppressor inhibiting liver cancer progression through MAPK/JNK and PI3K/AKT signaling pathways.

CARCINOGENESIS (2021)

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Article Cell Biology

UNC5B-AS1 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells via regulating miR-4306/KDM2A axis

Xiyin Huang et al.

Summary: UNC5B-AS1 is upregulated in HCC tissues and cells, contributing to cancer staging and patient survival rate. Its deficiency inhibits cell proliferation, migration, and EMT in HCC cells. UNC5B-AS1 interacts with miR-4306 and accelerates HCC progression via the miR-4306/KDM2A axis.

CELL CYCLE (2021)

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Article Oncology

LINC00680 enhances hepatocellular carcinoma stemness behavior and chemoresistance by sponging miR-568 to upregulate AKT3

Gege Shu et al.

Summary: The study demonstrates that LINC00680 is significantly upregulated in HCC tissues, and its high level is associated with poorer prognosis in patients. Overexpression of LINC00680 significantly enhances HCC cell stemness and reduces in vitro and in vivo chemosensitivity to 5-fluorouracil (5-Fu), while knockdown of LINC00680 leads to opposite results. Mechanism study reveals that LINC00680 regulates HCC stemness and chemosensitivity through sponging miR-568, thereby expediting the expression of AKT3.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway

Decai Chi et al.

Summary: CLEC12B, a C-type lectin-like receptor, is down-regulated in lung cancer, leading to increased cell proliferation and cell cycle entry, while inhibiting cell apoptosis. This process may be mediated through the PI3K/AKT signaling pathway.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44

Weijian Li et al.

Summary: Prostate cancer (PCa) is a common malignancy in men, and YTHDF1 may play a role in promoting PCa progression. This study found that YTHDF1 is highly expressed in PCa tissues and cells, and its inhibition can decrease cell proliferation, migration, and invasion. YTHDF1 may enhance PCa cell proliferation, migration, and invasion by regulating TRIM44 expression.

GENES & GENOMICS (2021)

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Review Biochemistry & Molecular Biology

Mechanisms of Long Non-Coding RNAs in Biological Characteristics and Aerobic Glycolysis of Glioma

Ningning Zhao et al.

Summary: Glioma is a common and aggressive brain tumor with poor prognosis due to uncontrolled proliferation and metabolic reprogramming. Long noncoding RNAs play diverse roles in shaping the biological features of glioma, but more research is needed to fully understand their mechanisms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

3D tumor angiogenesis models: recent advances and challenges

Sharath M. Bhat et al.

Summary: Angiogenesis is a complex process that plays a crucial role in tumor growth and metastasis. Various independent mechanisms inducing angiogenesis in tumors have been identified, including HIF-1/VEGF mediated paracrine interactions and recruitment of endothelial cells. However, existing angiogenesis models often rely on normal endothelial cells, which differ significantly from tumor endothelial cells, highlighting the need for improved models in personalized medicine.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Article Oncology

Stachydrine inhibits TGF-β1-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells through the TGF-β/Smad and PI3K/Akt/mTOR signaling pathways

Xiangni Chen et al.

Summary: Stachydrine was found to suppress TGF-β1-induced EMT in HCC cells by inhibiting cell migration and invasion, which was achieved by blocking the activation of Smad2/3 and PI3K/Akt/mTOR signaling pathways.

ANTI-CANCER DRUGS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Medicine, Research & Experimental

REC8 promotes tumor migration, invasion and angiogenesis by targeting the PKA pathway in hepatocellular carcinoma

Jing Han et al.

Summary: The study revealed that REC8 promotes the migration, invasion, and angiogenesis of HCC cells through the PKA pathway. REC8 was found to be mainly located in the nucleus of HCC tissue cells and cell lines, with a correlation between high expression and positive alpha-fetoprotein levels. Additionally, REC8 was shown to accelerate metastasis in vitro, while metastasis was suppressed after REC8 silencing.

CLINICAL AND EXPERIMENTAL MEDICINE (2021)

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Review Oncology

Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pie-ces of an Incomplete Puzzle for Lung Cancer Therapy

Milad Ashrafizadeh et al.

Summary: Long non-coding RNAs (lncRNAs) play a crucial role in regulating epithelial-to-mesenchymal transition (EMT) in lung cancer. Some lncRNAs have tumor-suppressing effects by inhibiting EMT and metastasis, while others have tumor-promoting effects by triggering EMT and enhancing migration of cancer cells. Targeting lncRNAs could be important in controlling the migration of lung cancer cells.

CURRENT CANCER DRUG TARGETS (2021)

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Article Biochemistry & Molecular Biology

CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

Tao Jiang et al.

Summary: The study demonstrates that upregulation of circIL4R in CRC plays an oncogenic role by promoting CRC cell proliferation, migration, and invasion through activation of the PI3K/AKT signaling pathway. Targeting circIL4R may serve as a potential diagnostic and prognostic biomarker for CRC detection and treatment.

MOLECULAR CANCER (2021)

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Review Biochemistry & Molecular Biology

Crosstalk between autophagy and microbiota in cancer progression

Yu Wang et al.

Summary: Autophagy is a conserved catabolic process in eukaryotes that plays a crucial role in cancer development. Dysregulation of autophagy is associated with promoting cancer cell survival and triggering cell death. The complex relationship between autophagy and microorganisms can protect the body by activating the immune system.

MOLECULAR CANCER (2021)

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Article Cell Biology

KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation

Yu-Shui Ma et al.

Summary: This study investigates the role of KDM5A in angiogenesis and mechanisms in HCC, revealing that KDM5A suppresses miR-433 and activates the FXYD3-PI3K-AKT axis to promote HCC progression.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Gastroenterology & Hepatology

C2orf40 inhibits hepatocellular carcinoma through interaction with UBR5

Yue Wu et al.

Summary: C2orf40 plays a role in HCC related to the methylation of its promoter, inhibiting liver cancer cell growth and migration by inducing G0/G1 phase arrest and apoptosis, and reversing the EMT process. Additionally, C2orf40 can increase p21 expression by interacting with UBR5.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Cell Biology

Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGFβR Regulating TGF-β/Smad Pathway

Haiyan Du et al.

Summary: Recent studies have shown that BBR can inhibit the migration, invasion, and EMT of tumor cells by modulating multiple signaling pathways, exhibiting anti-cancer activity similar to PI3K inhibitors and TGF-beta receptor inhibitors.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Oncology

Effect of PI3K/AKT/mTOR Signaling Pathway on Regulating and Con- trolling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin

Xia Sheng et al.

Summary: This study explored the effect of Bufalin on regulating invasion and metastasis of liver cancer cells through the PI3K/AKT/mTOR autophagy-related signaling pathway. Inhibiting autophagy enhanced the inhibitory effect of Bufalin on cell adhesion, migration, and invasion. Bufalin significantly influenced the expression of key proteins involved in proliferation, matrix degradation, and angiogenesis, suggesting its potential as a novel therapeutic strategy for preventing metastasis of liver cancer.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2021)

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Article Cell Biology

Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

Chuan Tian et al.

Summary: The study demonstrates that Linc-ROR plays an oncogenic role in hepatocellular carcinoma through positive regulation of DEPDC1 expression, potentially serving as a target for anticancer therapies.

CELL DEATH & DISEASE (2021)

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Article Biochemistry & Molecular Biology

Dantrolene Potentiates the Antineoplastic Effect of Sorafenib in Hepatocellular Carcinoma via Targeting Ca+2/PI3K Signaling Pathway

Sherin Zakaria et al.

Summary: The study demonstrated that dantrolene has synergistic effects when used in combination with sorafenib in HCC treatment, by reducing p53, VEGF, MMP-9, Cyclin D1, and Ki-67. Additionally, dantrolene was found to inhibit the Ca+2/PI3K pathway, enhancing its antineoplastic action either alone or in combination with sorafenib.

CURRENT MOLECULAR PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers

Asal Jalal Abadi et al.

Summary: miRNAs play vital roles in breast and lung cancer by regulating the PTEN signaling pathway. The dysregulation of miRNAs in breast and lung cancers is associated with the malignant behavior of tumors.

BIOMOLECULES (2021)

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Article Pathology

The role of different PI3K protein subtypes in the metastasis, angiogenesis and clinical prognosis of hepatocellular carcinoma

Na Che et al.

Summary: The study found that PI3Kp110 alpha and PI3Kp110 delta play roles in HCC metastasis and angiogenesis, and patients with high expression of these proteins have worse prognosis and shorter survival time. PI3Kp110 alpha is identified as an independent risk factor for HCC patients.

ANNALS OF DIAGNOSTIC PATHOLOGY (2021)

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Article Oncology

Medical ozone induces proliferation and migration inhibition through ROS accumulation and PI3K/AKT/NF-κB suppression in human liver cancer cells in vitro

J. Li et al.

Summary: The study demonstrates that ozone treatment can inhibit the proliferation, colony formation and migration ability of liver cancer cells, induce G2/M phase cell cycle arrest, and achieve anticancer effects through ROS accumulation and inactivation of the PI3K/AKT/NF-kappa B pathway.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

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Article Pharmacology & Pharmacy

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway

Jiatian Lin et al.

Summary: Tenacissoside H (TEH) increases radiosensitivity of hepatocellular carcinoma cells by regulating the PI3K/Akt/mTOR signaling pathway, and suppresses cell growth and promotes apoptosis through inducing autophagy and apoptosis.

DOSE-RESPONSE (2021)

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Article Oncology

TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis

Yang Sun et al.

Summary: TRPC1, as the major variant of the TRPC family in colorectal cancer (CRC) patients, is upregulated in CRC tissues and associated with aggressive tumor progression and poor survival. TRPC1 promotes CRC tumorigenesis and progression by activating the CaM-mediated PI3K/AKT signaling axis. Targeting TRPC1 may offer a novel approach for CRC treatment.

ONCOGENESIS (2021)

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Article Biotechnology & Applied Microbiology

Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway

Yange Wu et al.

Summary: The study revealed that TSPAN1 is highly expressed in breast cancer tumor samples and cell lines, and plays a role in regulating growth and motility through EMT and the PI3K/Akt pathway. Depletion of TSPAN1 suppressed tumor growth in breast cancer in mice, suggesting it could be a potential target for treatment.

BIOENGINEERED (2021)

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Article Biotechnology & Applied Microbiology

Ropivacaine suppresses tumor biological characteristics of human hepatocellular carcinoma via inhibiting IGF-1R/PI3K/AKT/mTOR signaling axis

Runze Zhang et al.

Summary: Ropivacaine inhibits proliferation, promotes apoptosis, suppresses migration and invasion, and targets the IGF-1R/PI3K/AKT/mTOR signaling pathway to suppress hepatocellular carcinoma progression.

BIOENGINEERED (2021)

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Article Oncology

Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway

Loukik Arora et al.

Summary: STAT3 is a major oncogenic transcription factor that is constitutively activated in various human cancers, including HCC and MM. Tris DBA, a palladium-based compound, has shown inhibitory efficacy on STAT3 signaling in preclinical cancer models by elevating the expression of SHP2 and inhibiting cell proliferation, migration, invasion, and tumor metastasis. This study provides evidence for the potential consideration of Tris DBA in clinical trials for cancer treatment.

CANCERS (2021)

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Review Oncology

Autophagy in Cancer Therapy-Molecular Mechanisms and Current Clinical Advances

Ingo Ganzleben et al.

Summary: Autophagy is the ability of cells to dismantle and recycle parts of themselves, closely related to cell growth and metabolism control. Dysregulation of autophagy in cancer provides protection and proliferation advantage for tumors. Autophagy plays important roles in various diseases, from neurodegeneration to cancer, especially depending on the cell type and proliferative state. In cancer, autophagy sustains cancer cell survival under challenging conditions but also leads to dependency on autophagy.

CANCERS (2021)

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Article Oncology

LY294002 Is a Promising Inhibitor to Overcome Sorafenib Resistance in FLT3-ITD Mutant AML Cells by Interfering With PI3K/Akt Signaling Pathway

Amin Huang et al.

Summary: This study discusses the resistance of AML patients with FLT3-ITD mutation to sorafenib, potentially due to the loss of the FLT3 target protein and sustained activation of the PI3K/Akt signaling pathway. The PI3K inhibitor, LY294002, can block this pathway and inhibit glycolysis, disrupting ATP production and inducing cell apoptosis.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression

Yang Ji et al.

Summary: CircCRIM1 is upregulated in hepatocellular carcinoma (HCC) and is associated with poor prognosis, enhancing cell proliferation and angiogenesis. It promotes HCC progression via the miR-378a-3p/SKP2 axis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Public, Environmental & Occupational Health

Disparities in Hepatocellular Carcinoma Survival by Insurance Status: A Population-Based Study in China

Jing Wu et al.

Summary: This study reveals that HCC patients covered by URRBMI may have worse survival than patients covered by UEBMI. Further efforts are warranted to understand healthcare disparities for patients covered by different basic medical insurance in China.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Oncology

CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27(kip1) Axis

Xin Zhou et al.

Summary: The study revealed that CYP2C8 is down-regulated in HCC tissues and plays a role in restricting the malignant phenotype and sorafenib resistance of HCC cells through the PI3K/Akt/p27Kip1 axis.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Review Oncology

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Mahshid Deldar Abad Paskeh et al.

Summary: This review discusses the role of Wnt signaling in hepatocellular carcinoma (HCC), including its promotion of HCC progression, impact on therapy response, and regulation of drug resistance and immune resistance mechanisms. Research shows that beta-catenin signaling in HCC cells can enhance cancer stem cell features, promote growth, and inhibit apoptosis, thus accelerating cancer development.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Article Oncology

Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways

Jifu Song et al.

Summary: Apatinib has been shown to inhibit proliferation, migration, invasion, and angiogenesis of HCC cells by downregulating VEGF and PI3K/AKT pathways, suggesting it as an effective therapeutic strategy for the treatment of HCC.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF-1α pathway

Ruyue Xu et al.

Summary: The study found that the PI3K inhibitor LY-294002 can enhance the chemosensitivity of liver cancer cells to oxaliplatin by inhibiting the PI3K/AKT signaling pathway, potentially through the inhibition of HIF-1 alpha expression.

MOLECULAR MEDICINE REPORTS (2021)

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Article Cell Biology

CircETFA upregulates CCL5 by sponging miR-612 and recruiting EIF4A3 to promote hepatocellular carcinoma

Chen Lu et al.

Summary: The study revealed that circETFA is overexpressed in HCC and associated with a poor prognosis, promoting the malignant progression of HCC through various mechanisms. It has the potential to serve as a novel biomarker and therapeutic target for HCC.

CELL DEATH DISCOVERY (2021)

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Article Medicine, General & Internal

Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma

Shen Shen et al.

Summary: This study revealed that E2F2 expression is generally upregulated in HCC, and high E2F2 expression is associated with poor prognosis in patients. Additionally, the co-expressed genes of E2F2 and its relationship with immunity were explored, providing insights into potential therapeutic targets for the molecular treatment of HCC.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

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Review Pharmacology & Pharmacy

Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Hardeep Singh Tuli et al.

Summary: Deguelin, a natural rotenoid from plants, has shown promising antineoplastic effects in different cancer subtypes by inhibiting tumor growth and metastasis through various signaling pathways. Initial scientific findings suggest deguelin as a potential anticancer agent for monotherapy or in combination with chemotherapy.

PHARMACOLOGICAL RESEARCH (2021)

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Article Cell Biology

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

Xiaoqing Luo et al.

Summary: CD36 is highly expressed in HCC, promoting the growth and metastasis of cancer cells through induction of aerobic glycolysis via activation of the Src/PI3K/AKT/mTOR signaling pathway.

CELL DEATH & DISEASE (2021)

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Review Gastroenterology & Hepatology

The role of miRNA125b in the progression of hepatocellular carcinoma

Minghao Yang et al.

Summary: miR-125b, as a significant miRNA, plays a crucial role in predicting and prognosing hepatocellular carcinoma (HCC). It inhibits the development of HCC and is highly accurate in prediction, making it a valuable predictive marker of HCC.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2021)

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Article Biotechnology & Applied Microbiology

BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy

Weiya Cao et al.

Summary: The study demonstrated that BEZ235 enhanced the sensitivity of sorafenib by suppressing the PI3K/AKT/mTOR pathway and inducing autophagy, promoting apoptosis and inhibiting the growth of hepatocellular carcinoma.

BIOMED RESEARCH INTERNATIONAL (2021)

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Review Oncology

Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis

Arpita Datta et al.

Summary: The cellular process of EMT is a critical mechanism in cancer metastasis, involving reorganization of the cytoskeleton composed of actin filaments, microtubules, and intermediate filaments. Understanding the physiological functions of the cytoskeleton and targeting key components for EMT regulation may offer promising approaches for cancer therapy, particularly in tackling multidrug-resistant cancer cells.

CANCERS (2021)

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Article Cell Biology

Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

Zetian Shen et al.

Aging-US (2021)

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Article Medicine, Research & Experimental

New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities

Milad Ashrafizadeh et al.

Summary: EMT mechanism is responsible for cancer cell metastasis and migration, as well as drug resistance. Taxene chemotherapeutic agents PTX and DTX induce cancer cell cycle arrest by preventing microtubule depolymerization, while upstream mediators of EMT such as ZEB1/2 and TGF-ll affect cancer cells' response to these drugs.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Design, synthesis, and biological evaluation of novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives as potential anticancer agents via PI3K inhibition

Huarong Yang et al.

Summary: Abnormal activation of the PI3K/Akt pathway has been demonstrated in most human malignant tumors, and targeting this pathway for drug discovery has attracted significant interest. In this study, novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives were designed and synthesized, with compounds 7i and 7m showing promising anticancer activity against various cancer cell lines, particularly HCC827 cells. These compounds also exhibited selectivity towards tumor cells over normal cells and induced G2/M phase arrests and apoptosis in HCC827 cells through the PI3K/Akt and caspase dependent pathway, suggesting their potential as lead compounds for anti-cancer drug development.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

MiR-27a-3p enhances the cisplatin sensitivity in hepatocellular carcinoma cells through inhibiting PI3K/Akt pathway

Ying Yang et al.

Summary: This study revealed that miR-27a-3p expression was down-regulated in HCC tissues and associated with metastasis, Child-Pugh grade, and race. Overexpression of miR-27a-3p inhibited cell growth, promoted apoptosis, and increased sensitivity to cisplatin in HCC, potentially through regulating the PI3K/Akt signaling pathway.

BIOSCIENCE REPORTS (2021)

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Article Oncology

[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

Xueyi Jiang et al.

Summary: The study found that 6-P can suppress the proliferation and metastasis of pancreatic cancer cells by decreasing EGFR protein expression level and inducing EGFR degradation, leading to inactivation of the PI3K/AKT signaling pathway. Additionally, ectopic expression of EGFR protein results in resistance to the therapeutic effects of 6-P. Furthermore, erlotinib can enhance the anticancer activity of 6-P.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

Regulation of Nuclear Factor-KappaB (NF-kB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Sepideh Mirzaei et al.

Summary: The NF-xB signaling pathway is a potential therapeutic target in cancer therapy, with its dysregulation impacting cancer cell proliferation, metastasis, and resistance to radiotherapy and chemotherapy. Non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, play a crucial role in modulating NF-xB signaling and may affect cancer progression by regulating miRNAs targeting NF-xB activation.

CANCER LETTERS (2021)

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Article Oncology

Resveratrol for cancer therapy: Challenges and future perspectives

Boxu Ren et al.

Summary: Despite its potential anticancer effects, resveratrol faces obstacles in clinical translation due to poor pharmacokinetics, low potency, and nephrotoxicity in certain patients. New strategies to enhance its bioavailability and develop more potent analogues are proposed to overcome these challenges and advance resveratrol in cancer therapy.

CANCER LETTERS (2021)

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Article Cell Biology

microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway

Xiao-Li Yang et al.

Summary: miR-873 can suppress the self-renewal and proliferation of pancreatic cancer stem cells by blocking PLEK2-dependent PI3K/AKT pathway. This study contributes to understanding the role of miR-873 in pancreatic cancer stem cells and its underlying molecular mechanisms to aid in the development of effective pancreatic cancer therapeutics.

CELLULAR SIGNALLING (2021)

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Article Pharmacology & Pharmacy

MiR-92a-3p Promotes the Malignant Progression of Hepatocellular Carcinoma by Mediating the PI3K/AKT/mTOR Signaling Pathway

Libing Wang et al.

Summary: miR-92a-3p plays a tumor-promoting role in HCC and may be a potential biomarker for the diagnosis and prognosis of HCC.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Pharmacology & Pharmacy

HM-3-HSA exhibits potent anti-angiogenesis and antitumor activity in hepatocellular carcinoma

Ting Li et al.

Summary: HM-3-HSA demonstrates antitumor activity against hepatocellular carcinoma and inhibits tumor angiogenesis by binding to HUVECs and suppressing downstream protein kinases. This study reveals the mechanism by which HM-3-HSA exerts its anti-angiogenic effects.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition

Mashan L. Abdullah et al.

Summary: The use of eugenol, a phenolic phytochemical extracted from certain essential oils, shows promising anti-cancer effects against triple-negative and HER2-positive breast cancer cells by targeting the caspase pathway and inducing autophagic cell death. Jurat et al. demonstrated that eugenol inhibits cell proliferation, increases protein levels associated with apoptosis, and induces autophagy in cancer cells, suggesting its potential as a natural anti-cancer agent.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-κB Signaling through PTEN Activation in Hepatocellular Carcinoma

Sang Eun Ha et al.

Summary: SCU as a potential agent for HCC therapy inhibits cell proliferation and metastasis in HepG2 cells through upregulation of PTEN and inhibition of the PI3K/Akt/NF-kappa B signaling pathway. It is a natural based agent that shows promise in improving therapeutic outcomes for HCC treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Local anesthetic bupivacaine inhibits proliferation and metastasis of hepatocellular carcinoma cells via suppressing PI3K/Akt and MAPK signaling

Lei Wang et al.

Summary: Bupivacaine has shown inhibitory effects on proliferation, migration, and invasion of HCC cells, as well as induction of apoptosis. The drug achieves this through suppression of the PI3K/Akt and MAPK signaling pathways.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Betulinic acid exerts antigenotoxic and anticarcinogenic activities via inhibition of COX-2 and PCNA in rodents

Natalia H. Ferreira et al.

Summary: Phytochemical betulinic acid (BA) shows potential chemopreventive effects against cancer by reducing chromosomal damage and preneoplastic lesions, as well as decreasing the expression of COX-2 and PCNA in the colon, indicating promising anticancer activity, especially for colorectal cancer.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Article Cell Biology

CCAT2 enhances autophagy-related invasion and metastasis via regulating miR-4496 and ELAVL1 in hepatocellular carcinoma

Jing Shi et al.

Summary: The study found that lncRNA CCAT2 is significantly upregulated in HCC tissues, correlating with advanced stage and venous invasion. Further experiments revealed that CCAT2 induces autophagy and promotes migration and invasion in vitro and in vivo. Mechanistic investigations showed that CCAT2 regulates HCC by affecting miR-4496/Atg5 in the cytoplasm and binding with ELAVL1/HuR in the nucleus to facilitate HCC progression.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Oncology

Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT

Qing Li et al.

Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Pharmacology & Pharmacy

O2-(2,4-dinitrophenyl) diazeniumdiolate derivative induces G2/M arrest via PTEN-mediated inhibition of PI3K/Akt pathway in hepatocellular carcinoma cells

Ling Liu et al.

Summary: The study found that JS-K could induce cell G2/M arrest through PTEN-mediated inhibition of the PI3K/Akt pathway, leading to apoptosis of hepatocellular carcinoma cells and inhibition of tumor growth. However, the effects of G2/M cell arrest and inhibition induced by JS-K could be reversed by bpv(pic) and Carboxy-PTIO.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway

Kai Fang et al.

Summary: This study found that bufalin inhibits tumor microenvironment-mediated angiogenesis by targeting the STAT3 signaling pathway in vascular endothelial cells. This suggests that bufalin may be used as a new antiangiogenic adjuvant therapy for treating colorectal cancer.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

External validation of hepatocellular carcinoma risk scores in patients with chronic hepatitis B virus infection in China

Tao Lou et al.

Summary: Several scoring systems were compared in Chinese patients with chronic HBV infection to predict the risk of HCC occurrence. CU-HCC and mPAGE-B scores were found to accurately predict HCC risk, with patients scoring <5 in CU-HCC or <9 in mPAGE-B potentially exempt from HCC surveillance within 36 months.

JOURNAL OF VIRAL HEPATITIS (2021)

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Letter Medicine, General & Internal

Circular circPSMC3 inhibits hepatocellular carcinoma migration and invasion by upregulating RBM5

Biao Tang et al.

MINERVA MEDICA (2021)

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Review Biochemistry & Molecular Biology

Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products

Iksen et al.

Summary: Lung cancer is a common and highly lethal cancer, posing a major clinical challenge. The PI3K/AKT/mTOR pathway has been linked to lung cancer, making it a significant therapeutic target. Interest in targeting these pathways with medications has grown, showing promise in various types of studies.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway

Yi Wang et al.

Summary: Cholangiocarcinoma (CCA) is characterized by high PLVAP expression levels, which are associated with poorer overall survival and higher micro-vessel density in CCA tissues. The DKK1/CKAP4/PI3K/PLVAP pathway plays a crucial role in promoting angiogenesis in CCA, making it a potential target for anti-angiogenic therapy.

ONCOGENE (2021)

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Review Pharmacology & Pharmacy

Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

Sepideh Mirzaei et al.

Summary: Caffeic acid and caffeic acid phenethyl ester have anti-tumor activity and can impact cancer progression through multiple molecular pathways, as well as enhance the response of cancer cells to chemotherapy.

PHARMACOLOGICAL RESEARCH (2021)

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Article Medicine, Research & Experimental

NEIL3 contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling

Weichen Wang et al.

Summary: In liver cancer, high NEIL3 expression is associated with tumor grade and survival time. NEIL3 is abundantly expressed in liver cancer cell lines, and its knockdown impairs cell functions, causes cell cycle arrest at G2 phase, and increases apoptotic rate. Additionally, NEIL3 regulates the PI3K/Akt/mTOR signaling pathway in liver cancer.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Medicine, Research & Experimental

An immunogenomic signature for molecular classification in hepatocellular carcinoma

Weiwei Zhuang et al.

Summary: This study investigated molecular classification and prognostic value in hepatocellular carcinoma (HCC) based on immune signature. Three HCC subtypes were identified, with Immunity_H subtype showing better survival rate. IL18RAP and IL7R were protective genes, and immune risk score was an independent risk factor for overall survival in HCC patients.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Oncology

MiR-137 inhibits cervical cancer progression via down-modulating Notch1 and inhibiting the PI3K/AKT/mTOR signaling pathway

Ying Gui et al.

Summary: The study found that miR-137 was down-regulated and Notch1 was up-regulated in cervical cancer cells. MiR-137 partially impeded cervical cancer progression through regulation of the Notch1 and PI3K/AKT/mTOR axis.

TRANSLATIONAL CANCER RESEARCH (2021)

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Article Oncology

Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways

Yuan Hu et al.

Summary: Apatinib inhibits the proliferation and migration of pancreatic cancer cells, leading to decreased Ki-67 expression and microvessel density, thus blocking tumor growth and angiogenesis. The underlying mechanism may involve phosphorylation of the PI3K/AKT and ERK1/2/MAPKs signaling pathways.

TRANSLATIONAL CANCER RESEARCH (2021)

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Review Oncology

Advances of Targeted Therapy for Hepatocellular Carcinoma

Mengke Niu et al.

Summary: Hepatocellular carcinoma (HCC) is a significant global health issue, and targeted therapy has made a breakthrough in treating advanced HCC. The combination of targeted therapy with immune checkpoint inhibitors shows more potent anticancer effects.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

Autophagy Drives Galectin-1 Secretion From Tumor-Associated Macrophages Facilitating Hepatocellular Carcinoma Progression

Goutham Venkata Naga Davuluri et al.

Summary: Galectin-1 (Gal-1), a secretory lectin associated with hepatocellular carcinoma (HCC), can be actively secreted by tumor-associated macrophages (TAMs) in response to stimuli of HCC cells, leading to increased systemic levels of Gal-1 and HCC tumor growth in mice. Autophagy-regulated Gal-1 secretion from TAMs correlates with poor overall survival and progression-free survival rates of HCC patients, highlighting the pathological role of TAM-produced Gal-1 in HCC progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Food Science & Technology

4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells

Xiang Gao et al.

Summary: The natural flavonoid compound 4-hydroxyderricin (4-HD) derived from Angelica keiskei shows significant inhibitory effects on hepatocellular carcinoma (HCC) cells, by promoting apoptosis and cell cycle arrest through the PI3K/AKT/mTOR signaling pathway.

FOODS (2021)

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Article Oncology

Canagliflozin, a SGLT-2 inhibitor, relieves ER stress, modulates autophagy and induces apoptosis in irradiated HepG2 cells: Signal transduction between PI3K/AKT/GSK-3β/mTOR and Wnt/β-catenin pathways; in vitro

Mohamed Khairy Abdel-Rafei et al.

Summary: The combination of CAN and gamma-IR shows significant anti-tumor potential in inhibiting HepG2 cell proliferation and survival. It works by modulating glycolytic metabolism, autophagy, and apoptosis pathways, as well as disrupting signaling pathways related to tumor progression, ultimately improving treatment outcomes.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2021)

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Article Biochemistry & Molecular Biology

ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival

Hao Zhang et al.

Summary: The study identified the correlation between autophagy-related genes and the prognosis of hepatocellular carcinoma patients, and established a reliable prognostic model based on 12 genes. This model can effectively predict patients' survival time, reflecting their immune characteristics and status. Furthermore, ATIC inhibits autophagy and promotes the progression of liver cancer through the AKT/FOXO3 signaling pathway.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Cell Biology

Jolkinolide B attenuates laryngeal cancer cell growth and induces apoptosis via PTEN/PI3K/Akt signaling pathway

Lei Dong et al.

Summary: The study suggests that JB inhibits proliferation, migration, and invasion of laryngeal cancer cells while promoting apoptosis, possibly through modulation of the PI3K/Akt pathway.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2021)

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Article Oncology

Homoharringtonine inhibits the progression of hepatocellular carcinoma by suppressing the PI3K/AKT/GSK3β/Slug signaling pathway

Hong-Yuan Liu et al.

Summary: The study evaluated the antitumor efficacy of HHT on hepatocellular carcinoma (HCC) and revealed its underlying molecular mechanisms. In vitro experiments showed that HHT inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells, and induced cell cycle arrest at the G2 phase and apoptosis. In vivo experiments demonstrated a significant tumor-suppressive effect of HHT on HCC, and indicated that HHT suppressed the growth of HCC at least partially through the PI3K/AKT/GSK3 beta/Slug signaling pathway.

NEOPLASMA (2021)

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Article Oncology

CD73 is a hypoxia-responsive gene and promotes the Warburg effect of human gastric cancer cells dependent on its enzyme activity

Xiaopeng Cao et al.

Summary: The research revealed that CD73 is associated with glycolysis in gastric cancer and induced by hypoxia. Genetic silencing of CD73 reduces cell proliferation and glycolytic ability, while overexpression has the opposite effect. Pharmacological inhibition of CD73 activity or hijacking tumor glycolysis can inhibit its oncogenic roles.

JOURNAL OF CANCER (2021)

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Article Cell Biology

miR-4677-3p participates proliferation and metastases of gastric cancer cell via CEMIP-PI3K/AKT signaling pathway

Chen Mi et al.

Summary: Gastric cancer ranks among the top three leading causes of cancer-related deaths globally. The dysregulation of miR-4677-3p has been linked to the modulation of invasion and migration in various cancer cell types. This study demonstrates that miR-4677-3p is down-regulated in gastric cancer tissues and cells, and over-expression of miR-4677-3p suppresses cell proliferation, migration, and invasion by targeting the CEMIP-PI3K/AKT signaling pathway axis.

CELL CYCLE (2021)

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Article Oncology

MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis

Mei-Juan Dian et al.

Summary: In this study, low MST4 expression was found to be highly associated with the advanced progression of HCC and serve as a prognostic biomarker for HCC patients of clinical-stage III-IV. Functional studies revealed that MST4 inactivation induced EMT of HCC cells, promoted their migratory and invasive potential in vitro, and facilitated intrahepatic metastasis in vivo, while MST4 overexpression exhibited opposite phenotypes. Mechanistically, MST4 inactivation elevated the expression and nuclear translocation of Snail1 through the PI3K/AKT signaling pathway, inducing the EMT phenotype of HCC cells and enhancing their invasive and metastatic potential.

JOURNAL OF CANCER (2021)

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Article Biology

MicroRNA-92b augments sorafenib resistance in hepatocellular carcinoma via targeting PTEN to activate PI3K/AKT/mTOR signaling

Zhouyang Cheng et al.

Summary: The study found that miR-92b plays a significant role in mediating sorafenib resistance in hepatocellular carcinoma cells by directly targeting PTEN and activating the PI3K/AKT/mTOR pathway, leading to increased resistance to sorafenib treatment.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2021)

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Article Oncology

Asparagus Polysaccharide inhibits the Hypoxia-induced migration, invasion and angiogenesis of Hepatocellular Carcinoma Cells partly through regulating HIF1α/VEGF expression via MAPK and PI3K signaling pathway

Wei Cheng et al.

Summary: Our research demonstrates that ASP effectively suppresses hypoxia-induced proliferation, migration, invasion, and angiogenesis of HCC cells, partly through regulating HIF-1 alpha/VEGF expression via MAPK and PI3K signaling pathways.

JOURNAL OF CANCER (2021)

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Article Biology

Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma

Zhuangqiang Wang et al.

Summary: Our study investigated the impact of upregulated PI3K/AKT signaling on hepatocellular carcinoma, showing that abnormal expression contributes to apoptosis resistance. Overexpression of PTEN sensitized cells to chemotherapy drugs and induced apoptotic cell death, suggesting a potential therapeutic target for HCC.

OPEN LIFE SCIENCES (2021)

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Review Medicine, Research & Experimental

Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma

Fan-Hua Kong et al.

Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has high resistance to traditional chemotherapy. Sorafenib, an oral kinase inhibitor, has shown improved survival rates for advanced liver cancer patients, but its clinical application is limited by poor solubility and low bioavailability. Nanoparticles have been explored to enhance the therapeutic efficacy of sorafenib in treating HCC, offering new hope for liver cancer treatment.

THERANOSTICS (2021)

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Article Oncology

Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3

Ying Zhou et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Medicine, Research & Experimental

Paris saponin VII enhanced the sensitivity of HepG2/ADR cells to ADR via modulation of PI3K/AKT/MAPK signaling pathway

Gong-En Tang et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)

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Article Biochemistry & Molecular Biology

VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR-PI3K-AKT pathway

Guangyan Zhangyuan et al.

ONCOGENE (2020)

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Article Medicine, Research & Experimental

Positive feedback loop of FAM83A/PI3K/AKT/c-Jun induces migration, invasion and metastasis in hepatocellular carcinoma

Chen Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Oncology

Reprogramming of fatty acid metabolism in cancer

Nikos Koundouros et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Oncology

Bufalin reverses multidrug resistance by regulating stemness through the CD133/nuclear factor-kappa B/MDR1 pathway in colorectal cancer

Zhan Yueping et al.

CANCER SCIENCE (2020)

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Article Pharmacology & Pharmacy

Resistance of hepatocellular carcinoma to sorafenib can be overcome with co-delivery of PI3K/mTOR inhibitor BEZ235 and sorafenib in nanoparticles

Binquan Wu et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

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Review Biochemistry & Molecular Biology

Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

Mahshid Moballegh Nasery et al.

MOLECULES (2020)

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Review Pharmacology & Pharmacy

Topoisomerase inhibitors: Pharmacology and emerging nanoscale delivery systems

Ali Dehshahri et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Biotechnology & Applied Microbiology

Knockdown of FOXO6 Inhibits Glycolysis and Reduces Cell Resistance to Paclitaxel in HCC Cells via PI3K/Akt Signaling Pathway

Xixiang Yu et al.

ONCOTARGETS AND THERAPY (2020)

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Review Biochemistry & Molecular Biology

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

Xuejiao Chen et al.

BIOMOLECULES (2020)

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Article Medicine, Research & Experimental

A novel multitarget kinase inhibitor BZG with potent anticancer activity in vitro and vivo enhances efficacy of sorafenib through PI3K pathways in hepatocellular carcinoma cells

Li Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Oncology

Long noncoding RNA MALAT1 inhibits the apoptosis and autophagy of hepatocellular carcinoma cell by targeting the microRNA-146a/PI3K/Akt/mTOR axis

Ningfu Peng et al.

CANCER CELL INTERNATIONAL (2020)

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Article Pharmacology & Pharmacy

PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer?

Milad Ashrafizadeh et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Oncology

Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway

Ruijie Sun et al.

CANCER MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Pre-mRNA Processing Factor 8 Accelerates the Progression of Hepatocellular Carcinoma by Regulating the PI3K/Akt Pathway

Shouhan Wang et al.

ONCOTARGETS AND THERAPY (2020)

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Article Cell Biology

SDC1 promotes cisplatin resistance in hepatic carcinoma cells via PI3K-AKT pathway

Liquan Yu et al.

HUMAN CELL (2020)

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Article Cell Biology

RCC2 contributes to tumor invasion and chemoresistance to cisplatin in hepatocellular carcinoma

Qingmin Chen et al.

HUMAN CELL (2020)

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Article Cell Biology

Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma

Oluwaseun Adebayo Bamodu et al.

CELLS (2020)

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Article Pathology

Lidocaine inhibits the proliferation and invasion of hepatocellular carcinoma by downregulating USP14 induced PI3K/Akt pathway

Yi Zhang et al.

PATHOLOGY RESEARCH AND PRACTICE (2020)

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Article Oncology

Cetyltrimethylammonium Bromide Disrupts the Mesenchymal Characteristics of HA22T/VGH Cells Via Inactivation of c-Met/PI3K/Akt/mTOR Pathway

Chia-Herng Yue et al.

ANTICANCER RESEARCH (2020)

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Article Oncology

Puerarin 6-O-xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR

Long Li et al.

CANCER MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance

Milad Ashrafizadeh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

LncRNA HEIH Confers Cell Sorafenib Resistance in Hepatocellular Carcinoma by Regulating miR-98-5p/PI3K/AKT Pathway

Qian Shen et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Multidisciplinary Sciences

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma

Jong Hyun Lee et al.

JOURNAL OF ADVANCED RESEARCH (2020)

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Review Biochemistry & Molecular Biology

MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy

Milad Ashrafizadeh et al.

BIOMOLECULES (2020)

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Review Biochemistry & Molecular Biology

PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation

Milad Ashrafizadeh et al.

BIOMEDICINES (2020)

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Article Biochemistry & Molecular Biology

MiR-660-5p promotes the progression of hepatocellular carcinoma by interaction with YWHAH via PI3K/Akt signaling pathway

Yunyu Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Cell Biology

Loss of PTEN expression is associated with PI3K pathway-dependent metabolic reprogramming in hepatocellular carcinoma

Chuanzong Zhao et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Plant Sciences

The epigallocatechin gallate derivative Y6 inhibits human hepatocellular carcinoma by inhibiting angiogenesis in MAPK/ERK1/2 and PI3K/AKT/HIF-1α/VEGF dependent pathways

Zhi-Hong Liao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Chemistry, Medicinal

ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro

Lei Song et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Article Oncology

METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner

Yuntao Shi et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Health Care Sciences & Services

CaMKKβ regulates proliferation, apoptosis, and glycolysis of hepatocellular carcinoma via PI3K/AKT pathway

Tao Sheng et al.

ANNALS OF PALLIATIVE MEDICINE (2020)

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Article Immunology

Inhibition of B7-H4 promotes hepatocellular carcinoma cell apoptosis and autophagy through the PI3K signaling pathway

Tuan-Tuan Hao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Biotechnology & Applied Microbiology

CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway

Rui Cheng et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

MST4 inhibits human hepatocellular carcinoma cell proliferation and induces cell cycle arrest via suppression of PI3K/AKT pathway

Wei-Chao Hao et al.

JOURNAL OF CANCER (2020)

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Article Medicine, Research & Experimental

PEX5, a novel target of microRNA-31-5p, increases radioresistance in hepatocellular carcinoma by activating Wnt/β-catenin signaling and homologous recombination

Jie Wen et al.

THERANOSTICS (2020)

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Article Biochemistry & Molecular Biology

Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway

Changwei Dou et al.

ONCOGENE (2019)

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Article Oncology

Prognostic and Therapeutic Implications of Microvascular Invasion in Hepatocellular Carcinoma

Derek J. Erstad et al.

ANNALS OF SURGICAL ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

Zhaowu Ma et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Cell Biology

Conditioned media from adipocytes promote proliferation, migration, and invasion in melanoma and colorectal cancer cells

Jeong-Hyeon Ko et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Gastroenterology & Hepatology

Dbx2 exhibits a tumor-promoting function in hepatocellular carcinoma cell lines via regulating Shh-Gli1 signaling

Yan-Ting Hu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Long-term observation of hepatocellular carcinoma recurrence after liver transplantation at a European transplantation centre

Friedrich Foerster et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2019)

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Article Biochemistry & Molecular Biology

DUXAP10 inhibition attenuates the proliferation and metastasis of hepatocellular carcinoma cells by regulation of the Wnt/β-catenin and PI3K/Akt signaling pathways

Kun Han et al.

BIOSCIENCE REPORTS (2019)

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Article Cell Biology

Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk

Jiyao Sheng et al.

CELL PROLIFERATION (2019)

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Article Oncology

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110 and predicts poor prognosis

Xiao-Lu Ma et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade

Min Hee Yang et al.

MOLECULES (2019)

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Article Pathology

Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells

Lifeng Ma et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Review Oncology

Focus on Formononetin: Anticancer Potential and Molecular Targets

Samantha Kah Ling Ong et al.

CANCERS (2019)

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Article Biotechnology & Applied Microbiology

TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway

Tao Huang et al.

DISEASE MARKERS (2019)

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Article Plant Sciences

Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells

Sun Tae Hwang et al.

PHYTOMEDICINE (2019)

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Article Medicine, Research & Experimental

Calcium-Activated Chloride Channel A4 (CLCA4) Plays Inhibitory Roles in Invasion and Migration Through Suppressing Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Colorectal Cancer

Hua Chen et al.

MEDICAL SCIENCE MONITOR (2019)

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Article Oncology

Downregulation of SHIP2 by Hepatitis B Virus X Promotes the Metastasis and Chemoresistance of Hepatocellular Carcinoma through SKP2

Kuo-Jung Su et al.

CANCERS (2019)

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Article Oncology

lncRNA-PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway

Weidong Pan et al.

MOLECULAR ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways

Young Yun Jung et al.

MOLECULES (2019)

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Review Gastroenterology & Hepatology

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Cell Biology

SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway

Mao Zhang et al.

CELL DEATH & DISEASE (2019)

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Article Medicine, Research & Experimental

Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway

Youping Chen et al.

MEDICAL SCIENCE MONITOR (2019)

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Review Cell Biology

Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

Jun-Ting Cheng et al.

CELLS (2019)

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Article Oncology

Aurora-a confers radioresistance in human hepatocellular carcinoma by activating NF-κB signaling pathway

Ze-Tian Shen et al.

BMC CANCER (2019)

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Article Oncology

Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma

Junbin Liao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

The transcription factor Kruppel-like factor 5 promotes cell growth and metastasis via activating PI3K/AKT/Snail signaling in hepatocellular carcinoma

Tingting An et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics

Prakash P. Praharaj et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Medicine, Research & Experimental

Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells SMMC 7721 via PI3K/AKT/mTOR signal pathway

Li Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Biochemistry & Molecular Biology

Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade

Jong Hyun Lee et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Pharmacology & Pharmacy

Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway

Jong Hyun Lee et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Surgery

Risk Factors, Patterns, and Outcomes of Late Recurrence After Liver Resection for Hepatocellular Carcinoma A Multicenter Study From China

Xin-Fei Xu et al.

JAMA SURGERY (2019)

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BCL2L10/BECN1 modulates hepatoma cells autophagy by regulating PI3K/AKT signaling pathway

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The PI3K inhibitor copanlisib synergizes with sorafenib to induce cell death in hepatocellular carcinoma

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Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through beta-catenin-EGFR-PI3K-Akt-mTOR signaling pathway

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Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway

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Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma

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miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway

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Survivin-targeted drug screening platform identifies a matrine derivative WM-127 as a potential therapeutics against hepatocellular carcinoma

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PRMT9 promotes hepatocellular carcinoma invasion and metastasis via activating PI3K/Akt/GSK-3/Snail signaling

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RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways

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Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-/Smad and PI3K/Akt/mTOR Signaling Pathways

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Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway

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Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition

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Secretory Clusterin Mediates Oxaliplatin Resistance via the Gadd45a/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

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NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance

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Endothelial cell CD36 optimizes tissue fatty acid uptake

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HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways

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CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance

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Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells

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CLCA4 inhibits cell proliferation and invasion of hepatocellular carcinoma by suppressing epithelial-mesencnymal transition via PI3K/AKT signaling

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Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3/NF-B feedback loop

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Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

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TIPE Family of Proteins and Its Implications in Different Chronic Diseases

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C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells

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Y-box binding protein-1 promotes hepatocellular carcinoma-initiating cell progression and tumorigenesis via Wnt/β-catenin pathway

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HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway

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MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

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IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway

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Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth

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Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway

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EDG2 enhanced the progression of hepatocellular carcinoma by LPA/PI3K/AKT/mTOR signaling

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Protein kinase D2 contributes to TNF-α-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3β/β-catenin pathway in hepatocellular carcinoma

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Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways

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Hepatic Stellate Cells Induce Hepatocellular Carcinoma Cell Resistance to Sorafenib Through the Laminin-332/α3 Integrin Axis Recovery of Focal Adhesion Kinase Ubiquitination

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Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway

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Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway

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Effects of orexin A on glucose metabolism in human hepatocellular carcinoma in vitro via PI3K/Akt/mTOR-dependent and -independent mechanism

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Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma

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Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

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Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

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Correlation of PDK1 expression with clinicopathologic features and prognosis of hepatocellular carcinoma

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Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling

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Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway

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Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway

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Alpha fetoprotein mediates HBx induced carcinogenesis in the hepatocyte cytoplasm

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Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways

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MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

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Galectin-1 Triggers Epithelial-Mesenchymal Transition in Human Hepatocellular Carcinoma Cells

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Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3

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Emodin attenuates radioresistance induced by hypoxia in HepG2 cells via the enhancement of PARP1 cleavage and inhibition of JMJD2B

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Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells

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Justicidin A-Induced Autophagy Flux Enhances Apoptosis of Human Colorectal Cancer Cells via Class III PI3K and Atg5 Pathway

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EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma

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HAb18G/CD147 Promotes Radioresistance in Hepatocellular Carcinoma Cells: A Potential Role for Integrin β1 Signaling

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Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

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Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

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ANNUAL REVIEW OF NUTRITION, VOL 34 (2014)

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Epidermal Growth Factor Receptor Inhibition Attenuates Liver Fibrosis and Development of Hepatocellular Carcinoma

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CCL5 secreted from bone marrow stromal cells stimulates the migration and invasion of Huh7 hepatocellular carcinoma cells via the PI3K-Akt pathway

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Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

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11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways

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Obesity-associated mechanisms of hepatocarcinogenesis

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Bone morphogenetic protein 2 inhibits hepatocellular carcinoma growth and migration through downregulation of the PI3K/AKT pathway

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Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer

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Inhibition of Aurora-B suppresses HepG2 cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway in vitro

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YB-1 protein: functions and regulation

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Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers

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Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression

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Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib

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Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway

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Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway

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MUC15 Inhibits Dimerization of EGFR and PI3K-AKT Signaling and Is Associated With Aggressive Hepatocellular Carcinomas in Patients

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Recurrences of hepatocellular carcinoma following complete remission by transarterial chemoembolization or radiofrequency therapy: Focused on the recurrence patterns

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Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy

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Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway

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HBx induces HepG-2 cells autophagy through PI3K/Akt-mTOR pathway

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ADAM17 mediates hypoxia-induced drug resistance in hepatocellular carcinoma cells through activation of EGFR/PI3K/Akt pathway

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CD39 and CD73 in immunity and inflammation

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FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway

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Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment

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HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway

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CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma

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SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway

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Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma

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Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells

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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2012)

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The overexpression of AP-4 as a prognostic indicator for gastric carcinoma

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Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma

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PLOS ONE (2012)

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Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

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Understanding the metabolic basis of drug resistance Therapeutic induction of the Warburg effect kills cancer cells

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Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo

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CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial-Mesenchymal Transition in HCC Cells

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Alpha-fetoprotein: a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines

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Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma

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Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

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Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

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Medium-chain triglycerides impair lipid metabolism and induce hepatic steatosis in very long-chain acyl-CoA dehydrogenase (VLCAD)-deficient mice

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Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors

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HEPATOLOGY RESEARCH (2009)

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Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

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