miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay-A review

Bladder cancer (BC) is the 11th most popular cancer in females and 4th in males. A lot of efforts have been exerted to improve BC patients' care. Besides, new approaches have been developed to enhance the efficiency of BC diagnosis, prognosis, therapeutics, and monitoring. MicroRNAs (miRNAs, miRs) are small chain nucleic acids that can regulate wide networks of cellular events. They can inhibit or degrade their target protein-encoding genes. The miRNAs are either downregulated or upregulated in BC due to epigenetic alterations or biogenesis machinery abnormalities. In BC, dysregulation of miRNAs is associated with cell cycle arrest, apoptosis,

Automated summary

Bladder cancer is the 11th most popular cancer in females and 4th in males. Efforts have been made to improve BC patients' care, and new approaches have been developed to enhance the efficiency of BC diagnosis, prognosis, therapeutics, and monitoring.