A review on the role of LINC00173 in human cancers

Long intergenic non-protein coding RNA 173 (LINC00173) is a long non-coding RNA with especial function in the tumorigenic process. Studies in different types of cancers support an oncogenic role for LINC00173 except for studies in B-cell precursor acute lymphoblastic leukemia, cervical cancer, pancreatic cancer and gastric cancer. In breast and lung cancers, both oncogenic and tumor suppressor roles have been reported for LINC00173. LINC00173 can serve as a molecular sponge for miRNAs. miR-218/Etk, miR-511-5p/VEGFA, miR-182-5p/ AGER, miR-765/NUTF2, miR-765/PLP2, miR-182-5p/FBXW7, miR-338-3p/Rab25, miR-641/RAB14 and miR1275/BCL2 are examples of the miRNA/mRNA axes being regulated by LINC00173 in the context of cancer. The current review provides a summary of different studies on the role of LINC00173 in these cancers.

Automated summary

Long intergenic non-protein coding RNA 173 (LINC00173) is a long non-coding RNA that plays a significant role in tumorigenesis. While most studies support its oncogenic role in various cancers, exceptions exist in B-cell precursor acute lymphoblastic leukemia, cervical cancer, pancreatic cancer, and gastric cancer. In breast and lung cancers, LINC00173 has been reported to have both oncogenic and tumor suppressor roles. It acts as a molecular sponge for miRNAs, regulating various miRNA/mRNA axes involved in cancer progression. This review summarizes the current understanding of LINC00173 in these cancers.