A review on the role of NR2F1-AS1 in the development of cancer

NR2F1-AS1 is a natural antisense transcript with prominent roles in the carcinogenesis. It acts as an oncogene in almost all types of cancers except for cervical and colorectal cancers. It can act as a molecular sponge for miR-17, miR-371a-3p, miR-363, miR-29a-3p, miR-493-5p, miR-190a, miR-140, miR-642a, miR-363, miR-493-5p, miR483-3p, miR-485-5p, miR-146a-5p, miR-877-5p, miR-338-3 P and miR-423-5p to influence expression of several cancer-related genes. Thus, the sponging role of NR2F1-AS1 is the most appreciated route of its contribution in the carcinogenesis. In addition, NR2F1-AS1 affects activity of IGF-1/IGF-1R/ERK, PI3K/AKT/ GSK-3 beta and Hedgehog pathways. The current narrative review aims at summarization of the results of studies that highlighted the role of NR2F1-AS1 in the carcinogenesis.

Automated summary

NR2F1-AS1 is a natural antisense transcript that plays prominent roles in carcinogenesis. It acts as an oncogene in almost all types of cancers, except cervical and colorectal cancers. It functions as a molecular sponge for multiple miRNAs and affects the expression of cancer-related genes. Additionally, NR2F1-AS1 has an impact on several signaling pathways.