Journal
ORGANIC LETTERS
Volume 24, Issue 51, Pages 9375-9380Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03676
Keywords
-
Categories
Funding
- Agence Nationale de la Recherche [ANR-20-CE07-0008-01]
Ask authors/readers for more resources
Site-selective trifluoromethylation of silyl dienol ethers derived from alpha,ss-unsaturated aldehydes, ketones, and amides was achieved for the first time in the remote gamma position. An unprecedented enantioselective C(sp(3))-H perfluoroalkylation process is disclosed.
Site-selective trifluoromethylation of silyl dienol ethers derived from alpha,ss-unsaturated aldehydes, ketones, and amides was achieved for the first time in the remote gamma position. This photoredox catalyzed process is quite general to compounds bearing many functionalities and is applicable to the late-stage functionalization of biorelevant molecules. The use of S-perfluoroalkyl sulfoximines as center dot R-F radical sources enables the generalization of the reaction to other perfluoroalkyl groups (R-F = CF2H, C4F9). Importantly, an unprecedented enantioselective C(sp(3))-H perfluoroalkylation process is disclosed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available