Synthesis of Xanthones via Copper(II)-Catalyzed Dehydrogenative Cyclization and Successive Aromatization in a One-Step Sequence

In this study, an unprecedented approach to the xanthone scaffold from cyclohexyl(2-hydroxyphenyl)methanone via dehydrogenative cyclization and a successive aromatization cascade is reported. This methodology affords a novel route to the privileged structure with a wide substrate scope (a total of 29 compounds, <= 96% yield) in a highly atom-economic manner.

Automated summary

This study reports an unprecedented approach to synthesizing xanthone scaffold from cyclohexyl(2-hydroxyphenyl)methanone through dehydrogenative cyclization and aromatization cascade. This method offers a novel route with a high atom-economic manner and a wide substrate scope.