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ORGANIC LETTERS
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c04116
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The biorelevant sulfur-containing Euphorbia diterpenes with scarce 5/7/6/3 premyrsinane-and 5/7/6 myrsinanetype backbones were easily synthesized from naturally abundant lathyrane-type Euphorbia factor L3 by visible-light-triggered tandem thiol-ene click reaction/transannular cyclization and regioselective cyclopropane ring-opening. The universality of this synthesis route was confirmed by successfully obtaining the selenide diterpene. This concise synthesis strategy offers a mild and efficient method for obtaining structurally diverse Euphorbia diterpenes, including a promising anti-HIV bioactive premyrsinane diterpene 3h.
The biorelevant sulfur-containing Euphorbia diterpenes with scarce 5/7/6/3 premyrsinane-and 5/7/6 myrsinanetype backbones were easily constructed from naturally abundant lathyrane-type Euphorbia factor L3 by visible-light-triggered tandem thiol-ene click reaction/transannular cyclization and regioselective cyclopropane ring-opening. The selenide diterpene was also successfully obtained to verify the system universality. This concise synthesis route gives an efficient strategy for obtaining structurally diverse Euphorbia diterpenes under very mild conditions and provides a promising anti-HIV bioactive premyrsinane diterpene 3h.
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