Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 21, Issue 4, Pages 775-782Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob02001g
Keywords
-
Categories
Ask authors/readers for more resources
A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C-H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5,1-a]isoindoles is reported. The reaction shows good functional group compatibility and a broad substrate scope with up to 84% yields. Mechanistic studies suggest that the C-H cleavage may be the rate-determining step in this transformation.
A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C-H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5,1-a]isoindoles is described. The reaction features good functional group compatibility and a broad substrate scope with respect to both cyclization components with up to 84% yields. Mechanistic studies indicated that the C-H cleavage might be the rate-determining step in this transformation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available