Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 21, Issue 5, Pages 930-934Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob02124b
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Oxidative cross-coupling of two thiols is a direct and desirable method for synthesizing unsymmetrical disulfides. However, the formation of symmetrical by-products is a major issue. This study presents a method where the homo-coupling of thiols is effectively inhibited by sequential addition of the thiols, utilizing the rapid oxidation of thiols by bromodimethylsulfonium bromide.
Oxidative cross-coupling of two thiols is the most direct tool for the synthesis of unsymmetrical disulfides and highly desirable across academia and industry. However, the inevitable formation of significant amounts of the corresponding symmetrical by-products is a major issue. We herein present a method toward the synthesis of unsymmetrical disulfides in which the homo-coupling of the thiols is effectively inhibited by adding the two thiols sequentially, taking advantage of rapid oxidation of the thiol by bromodimethylsulfonium bromide.
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