Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 21, Issue 3, Pages 632-638Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob02203f
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In this study, hybrid molecules combining the structural motifs of geraniol and furan were synthesized, demonstrating enhanced antifouling activity against barnacle cypris larvae. The EC50 values of the nine synthetic hybrids ranged from 1.65 to 4.70 μg mL(-1), outperforming both geraniol and the reference furan compound. This approach of hybridization holds promise for increasing antifouling activity and can be applied to other active structural units as well.
Geraniol, a monoterpene, and furan are structural motifs that exhibit antifouling activity. In this study, monoterpene-furan hybrid molecules with potentially enhanced antifouling activity were designed and synthesized. The nine synthetic hybrids showed antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC50 values of 1.65-4.70 mu g mL(-1). This activity is higher than that of geraniol and the reference furan compound. This hybridization approach to increase antifouling activity is useful and can also be extended to other active structural units.
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