Journal
CELL
Volume 161, Issue 1, Pages 106-118Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.02.020
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Funding
- Bakewell Foundation
- Longer Life Foundation (an RGA/Washington University Partnership)
- National Center for Research Resources [UL1 RR024992]
- Italian Federation of Sport Medicine (FMSI)
- European Union's Seventh Framework Programme MOPACT [320333]
- Max Planck Society
- ERC
- Wellcome Trust (UK)
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Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake. Lowered intake of particular nutrients rather than of overall calories is also key, with protein and specific amino acids playing prominent roles. Nutritional modulation of the microbiome can also be important, and there are long-term, including inter-generational, effects of diet. The metabolic, molecular, and cellular mechanisms that mediate both improvement in health during aging to diet and genetic variation in the response to diet are being identified. These new findings are opening the way to specific dietary and pharmacological interventions to recapture the full potential benefits of dietary restriction, which humans can find difficult to maintain voluntarily.
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