Journal
CELL
Volume 161, Issue 1, Pages 119-132Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.03.008
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Funding
- Wellcome Trust
- MRC
- ERC
- NIHR Cambridge Biomedical Research Centre
- Bernard Wolfe endowment
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The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individuals. A more detailed mechanistic understanding of the molecular, physiological, and behavioral pathways involved in the development of obesity in susceptible individuals is critical for identifying effective mechanism-based preventative and therapeutic interventions.
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