Journal
CELL
Volume 162, Issue 3, Pages 478-487Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.07.022
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Funding
- Austrian Academy of Sciences
- ERC [250179]
- Swiss National Science Foundation [P300P3_147897]
- Marie Curie Actions International Fellowship Program (IFP) TransCure
- Swiss National Center of Competence in Research (NCCR TransCure)
- AbbVie
- Bayer Pharma AG
- Boehringer Ingelheim
- Eshelman Institute for Innovation
- Genome Canada
- Janssen
- Merck Co.
- Novartis Pharma AG
- Ontario Ministry of Economic Development and Innovation
- Pfizer
- Sao Paulo Research Foundation-FAPESP
- Takeda
- Wellcome Trust
- Swiss National Science Foundation (SNF) [P300P3_147897] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [250179] Funding Source: European Research Council (ERC)
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Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.
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