Nutrient transporters: connecting cancer metabolism to therapeutic opportunities

Cancer cells rely on certain extracellular nutrients to sustain their metabolism and growth. Solute carrier (SLC) transporters enable cells to acquire extracellular nutrients or shuttle intracellular nutrients across organelles. However, the function of many SLC transporters in cancer is unknown. Determining the key SLC transporters promoting cancer growth could reveal important therapeutic opportunities. Here we summarize recent findings and knowledge gaps on SLC transporters in cancer. We highlight existing inhibitors for studying these transporters, clinical trials on treating cancer by blocking transporters, and compensatory transporters used by cancer cells to evade treatment. We propose targeting transporters simultaneously or in combination with targeted therapy or immunotherapy as alternative strategies for effective cancer therapy.

Automated summary

Cancer cells depend on specific extracellular nutrients for their metabolism and growth. SLC transporters play a crucial role in acquiring these nutrients and transferring intracellular nutrients. Understanding the function of SLC transporters in cancer could provide therapeutic targets for effective treatment.