Journal
OCULAR IMMUNOLOGY AND INFLAMMATION
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/09273948.2022.2161398
Keywords
Endogenous endophthalmitis; epidemiology; Klebsiella pneumoniae; microbiology; virulence gene
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The purpose of this study was to investigate the clinical features and molecular characteristics of endogenous Klebsiella pneumoniae endophthalmitis (EKPE). Clinical data was collected retrospectively, and K. pneumoniae isolates from EKPE patients were characterized. Results showed that administration of systemic antibiotics and eye treatment within 24 hours of symptom onset was associated with better visual outcomes. Avirulent carbapenem-resistant K. pneumoniae strains were found to cause EKPE.
PurposeTo investigate the clinical features of endogenous Klebsiella pneumoniae endophthalmitis (EKPE) and the molecular characteristics of pathogenic K. pneumoniae.MethodsA retrospective study was conducted between January 2014 and January 2021. Clinical data were extracted. K. pneumoniae isolates cultured from EKPE patients' specimens were characterized by antimicrobial susceptibility testing, multilocus sequence typing, capsular serotyping, and virulence gene profiles. Virulence phenotypes were confirmed by mouse lethality assay.ResultsThirty-nine patients (47 eyes) were diagnosed with EKPE. Administration of systemic antibiotics and eye treatment within 24 hours of ocular symptom onset was statistically associated with better visual outcomes (p = .007). Sixteen K. pneumoniae isolates were collected, three of which were carbapenem-resistant and avirulent. Only salmochelin encoding gene was harbored by all isolates.ConclusionsSystemic and eye treatment administered within 24 hours from the onset improves visual prognosis. Besides hypervirulent strains, avirulent carbapenem-resistant K. pneumoniae can cause EKPE.
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