Journal
CELL
Volume 163, Issue 3, Pages 656-669Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.09.034
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Funding
- European Community's Seventh Framework Programme (FP7)/ERC [281869]
- Simons Foundation [324958]
- EMBO Long Term Fellowship [ALTF 345-2014]
- NIH training grant [F31 NS061697]
- NIH T32 training grant [T32 MH015174-38]
- Research Institute of Molecular Pathology (IMP)
- Boehringer Ingelheim
- European Research Council (ERC) [281869] Funding Source: European Research Council (ERC)
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While isolated motor actions can be correlated with activities of neuronal networks, an unresolved problem is how the brain assembles these activities into organized behaviors like action sequences. Using brain-wide calcium imaging in Caenorhabditis elegans, we show that a large proportion of neurons across the brain share information by engaging in coordinated, dynamical network activity. This brain state evolves on a cycle, each segment of which recruits the activities of different neuronal sub-populations and can be explicitly mapped, on a single trial basis, to the animals' major motor commands. This organization defines the assembly of motor commands into a string of run- and-turn action sequence cycles, including decisions between alternative behaviors. These dynamics serve as a robust scaffold for action selection in response to sensory input. This study shows that the coordination of neuronal activity patterns into global brain dynamics underlies the high-level organization of behavior.
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