Journal
CELL
Volume 163, Issue 4, Pages 988-998Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.10.027
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Funding
- NIH [R01 AI080289]
- Bill and Melinda Gates Foundation CAVD [OPP1032817]
- Ragon Institute of MGH, MIT and Harvard
- NIAID [HVTN204]
- [DARPA-BAA-11-65]
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While antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity. As antibodies mediate an array of extra-neutralizing Fc functions, when neutralization fails to predict protection, investigating Fc-mediated activitymay help identify immunological correlates and mechanism(s) of humoral protection. Here, we used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine trials. Each vaccine regimen induced a unique humoral Fc fingerprint. Moreover, analysis of case: control data from the first moderately protective HIV vaccine trial, RV144, pointed to mechanistic insights into immune complex composition that may underlie protective immunity to HIV. Thus, multi-dimensional relational comparisons of vaccine humoral fingerprints offer a unique approach for the evaluation and design of novel vaccines against pathogens for which correlates of protection remain elusive.
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