Journal
NUTRITION
Volume 105, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2022.111847
Keywords
Nonalcoholic fatty liver disease; Intermittent fasting; Liver enzymes; Time-restricted eating; diet; Fasting; Free sugar diet
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This study investigated the effects of time-restricted feeding (TRF) combined with a low-sugar diet on patients with non-alcoholic fatty liver disease (NAFLD). The results showed that TRF combined with a low-sugar diet can reduce adiposity, improve liver function, lipid profile, and inflammatory markers in patients with NAFLD.
Objectives: Emerging studies have employed time-restricted feeding (TRF) and a low-sugar diet alone in the management of non-alcoholic fatty liver disease (NAFLD), but their combination has not been tested. The aim of this study was to investigate the effects of TRF combined with a low-sugar diet on NAFLD parameters, cardiometabolic and inflammatory biomarkers, and body composition in patients with NAFLD. Methods: A 12-wk randomized controlled trial was performed to compare the effects of TRF (16 h fasting/8 h feeding daily [16/8]) plus a low-sugar diet versus a control diet based on traditional meal distribution in patients with NAFLD. Changes in body composition, anthropometric indices, and liver and cardiometabolic markers were investigated. Results: TRF 16/8 with a low-sugar diet reduced body fat (26.7 + 5.4 to 24.2 + 4.9 kg), body weight (83.8 + 12.7 to 80.5 + 12.1 kg), waist circumference (104.59 +/- 10.47 to 101.91 +/- 7.42 cm), and body mass index (29.1 +/- 2.6 to 28 +/- 2.7 kg/m(2)), as well as circulating levels of fasting blood glucose and liver (alanine aminotransferase, 34 +/- 13.9 to 21.2 +/- 5.4 U/L; aspartate aminotransferase, 26.3 +/- 6.2 to 20.50 +/- 4 U/L; gamma-glutamyl transpeptidase, 33 +/- 15 to 23.2 +/- 11.1 U/L; fibrosis score, 6.3 +/- 1 to 5.2 +/- 1.2 kPa; and controlled attenuation parameter, 322.9 +/- 34.9 to 270.9 36.2 dB/m), lipids (triacylglycerols, 201.5 +/- 35.3 to 133.3 +/- 48.7 mg/dL; total cholesterol, 190 +/- 36.6 to 157.8 +/- 33.6 mg/dL; and low-density lipoprotein cholesterol, 104.6 +/- 27.3 to 84 +/- 26.3 mg/dL), and inflammatory markers (high-sensitivity C-reactive protein, 3.1 +/- 1.1 to 2 +/- 0.9 mg/L; and cytokeratin-18, 1.35 +/- 0.03 to 1.16 +/- 0.03 ng/mL). These results were statistically significant (P < 0.05) compared with the control group. Conclusions: TRF plus a low-sugar diet can reduce adiposity and improve liver, lipid, and inflammatory markers in patients with NAFLD. (c) 2022 Elsevier Inc. All rights reserved.
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