Toll-like receptor-2 (TLR-2) rs111200466 variant offers protection against SARS-CoV-2 infections and mortality: a worldwide epidemiological correlation analysis

Article Virology

SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions

Remi Planes et al.

Summary: This study demonstrates the interaction between the SARS-CoV-2 envelope protein and TLR2 receptor, which activates the inflammatory response through the TLR2 pathway. The findings suggest that the envelope protein could serve as a potential molecular target for COVID-19 interventions, including therapeutic antibodies and vaccine development.

VIRUSES-BASEL (2022)

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Review Virology

Role of Toll-like receptors in the pathogenesis of COVID-19

Shaghayegh Khanmohammadi et al.

Summary: COVID-19 caused by SARS-CoV-2 has led to a pandemic. TLRs play a crucial role in activating the immune system in response to the virus, and could potentially be a target for controlling the infection. Understanding the mechanisms of TLR in COVID-19 may help in developing vaccines and treatments.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Immunology

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

Min Zheng et al.

Summary: The study revealed that the envelope protein of SARS-CoV-2 is sensed by TLR2, leading to the production of inflammatory cytokines, and the severity of the disease is associated with the expression of TLR2 and MYD88. The findings demonstrate the critical role of TLR2 signaling in promoting proinflammatory cytokine production during coronavirus infection, providing new insights for therapeutic strategies against the ongoing COVID-19 pandemic.

NATURE IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology