Journal
CELL
Volume 162, Issue 3, Pages 635-647Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.07.014
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Funding
- NRSA [1F32MH105053-01, 1F31MH105151-01]
- Hughes Collaborative Innovation Award (HCIA)
- NIMH Silvio Conte Center at Stanford [P50 MH086403]
- Simons Foundation
- Gatsby Foundation
- Wiegers Family Fund
- Nancy and James Grosfeld Foundation
- H. L. Snyder Medical Foundation
- Samuel and Betsy Reeves Fund
- Vincent VC Woo Fund
- Albert Yu Foundation
- Mary Bechman Foundation
- DARPA Neuro-FAST program
- NIMH
- NIDA
- NSF
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1247950] Funding Source: National Science Foundation
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Recent progress in understanding the diversity of midbrain dopamine neurons has highlighted the importance-and the challenges-of defining mammalian neuronal cell types. Although neurons may be best categorized using inclusive criteria spanning biophysical properties, wiring of inputs, wiring of outputs, and activity during behavior, linking all of these measurements to cell types within the intact brains of living mammals has been difficult. Here, using an array of intact-brain circuit interrogation tools, including CLARITY, COLM, optogenetics, viral tracing, and fiber photometry, we explore the diversity of dopamine neurons within the substantia nigra pars compacta (SNc). We identify two parallel nigrostriatal dopamine neuron subpopulations differing in biophysical properties, input wiring, output wiring to dorsomedial striatum (DMS) versus dorsolateral striatum (DLS), and natural activity patterns during free behavior. Our results reveal independently operating nigrostriatal information streams, with implications for understanding the logic of dopaminergic feedback circuits and the diversity of mammalian neuronal cell types.
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