4.3 Article

High-yield cyclotron production of 203Pb using a sealed 205Tl solid target

Related references

Note: Only part of the references are listed.
Article Radiology, Nuclear Medicine & Medical Imaging

Targeted a-Emitter Therapy with 212Pb-DOTAMTATE for the Treatment of Metastatic SSTR-Expressing Neuroendocrine Tumors: First-in-Humans Dose-Escalation Clinical Trial

Ebrahim S. Delpassand et al.

Summary: The targeted α-therapy with Pb-212-DOTAMTATE showed good tolerability and promising preliminary efficacy in treating patients with somatostatin receptor-positive NETs.

JOURNAL OF NUCLEAR MEDICINE (2022)

Review Radiology, Nuclear Medicine & Medical Imaging

Harnessing α-Emitting Radionuclides for Therapy: Radiolabeling Method Review

Hua Yang et al.

Summary: Targeted alpha-therapy is a promising tool for treating late-stage cancers. By using targeted radiopharmaceuticals, tissue- or cell-specific delivery of a-emitters can be achieved. Researchers are currently focusing on developing effective stable chelators for a-emitters, but there are still challenges to overcome.

JOURNAL OF NUCLEAR MEDICINE (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

First In Vivo and Phantom Imaging of Cyclotron-Produced 133La as a Theranostic Radionuclide for 225Ac and 135La

Bryce J. B. Nelson et al.

Summary: This study focuses on the clinical application of theranostic isotope pairs, specifically investigating the production of La-133 and its imaging characteristics for PET imaging. The study also successfully demonstrated high-resolution tumor visualization using La-133-PSMA-I&T in preclinical PET imaging.

JOURNAL OF NUCLEAR MEDICINE (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Cyclotron production of the 64Cu theranostic radiometal using a novel 68Zn sealed solid target

Bryce Nelson et al.

NUCLEAR MEDICINE AND BIOLOGY (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiolanthanum: Promising theranostic radionuclides for PET, alpha, and Auger-Meitner therapy

Bryce J. B. Nelson et al.

Summary: Lanthanum radiometals have the potential to serve as theranostic PET radiometals for targeted radionuclide therapy. La-132 and La-133 can be used as unique PET imaging agents for Ac-225 targeted alpha-particle therapy, the Ce-134/La-134 pair has PET imaging potential with both Ac-225 and Th-227, and La-135 has potential in targeted Auger-Meitner electron therapy. Recent advances in radiolanthanum production and preclinical applications show the strong potential of these radionuclides in PET and targeted radionuclide therapy.

NUCLEAR MEDICINE AND BIOLOGY (2022)

Article Chemistry, Medicinal

Production of GMP-Compliant Clinical Amounts of Copper-61 Radiopharmaceuticals from Liquid Targets

Alexandra I. Fonseca et al.

Summary: PET imaging, especially in oncology, has seen significant progress in recent years. This study explores the potential of using copper-61 as a radiopharmaceutical for somatostatin analogues. The researchers describe two possible routes for production and demonstrate that clinical doses of 61 Cu-based radiopharmaceuticals can easily be obtained.

PHARMACEUTICALS (2022)

Article Engineering, Biomedical

SPECT imaging of 226Ac as a theranostic isotope for 225Ac radiopharmaceutical development

Helena Koniar et al.

Summary: This study evaluated the performance of Ac-226 imaging using quantitative SPECT imaging and presented the first-ever Ac-226 SPECT images. The results showed the feasibility of preclinical imaging with Ac-226, which demonstrated high resolution. The HEUHR collimator was recommended for imaging the activity distribution of Ac-226 in small animals.

PHYSICS IN MEDICINE AND BIOLOGY (2022)

Article Chemistry, Medicinal

Efficient Production of the PET Radionuclide 133La for Theranostic Purposes in Targeted Alpha Therapy Using the 134Ba(p,2n)133La Reaction

Santiago Andres Bruehlmann et al.

Summary: Targeted Alpha Therapy is a highly researched field in specialized radionuclide therapy, with Ac-225 being a particularly effective radionuclide. The production and purification of La-133 as a diagnostic radionuclide is relatively simple and can be easily scaled up for clinical applications. The theranostic pairing of La-133 with Ac-225 provides a promising approach for targeted therapy.

PHARMACEUTICALS (2022)

Article Chemistry, Multidisciplinary

Developing the 134Ce and 134La pair as companion positron emission tomography diagnostic isotopes for 225Ac and 227Th radiotherapeutics

Tyler A. Bailey et al.

Summary: The development of targeted alpha therapies can potentially revolutionize disease treatment by delivering destructive radiation to diseased cells while sparing healthy tissue. Despite challenges with incompatible isotopes, researchers successfully produced Ce-134 for PET imaging, demonstrating its potential as a candidate for imaging Ac-225 or Th-227. Rigorous control of the Ce-III/Ce-IV redox couple was crucial for success in these experiments.

NATURE CHEMISTRY (2021)

Review Pharmacology & Pharmacy

Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications

Bryce J. B. Nelson et al.

Summary: This review discusses the therapeutic advantages of targeted alpha particle therapy, the properties and radiochemistry of common alpha-emitters, production techniques, ongoing and completed clinical trials, and future outlook of TAT.

PHARMACEUTICS (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Cyclotron-Produced 132La as a PET Imaging Surrogate for Therapeutic 225Ac

Eduardo Aluicio-Sarduy et al.

Summary: This study aimed to explore La-132 as a PET imaging surrogate for Ac-225 and validated its effectiveness and stability in tumor imaging. The results suggest that La-132 is a suitable alternative for probing the in vivo biodistribution of Ac-225 radiotherapeutics.

JOURNAL OF NUCLEAR MEDICINE (2021)

Article Chemistry, Medicinal

Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair

Brooke L. McNeil et al.

Summary: Lead-212 and lead-203 are a matched theranostic radioisotope pair suitable for targeted radionuclide therapy and single-photon emission computed tomography. Produced using TRIUMF's accelerators, these isotopes have high radiolabeling yields and are suitable for direct radiolabeling of chelators and bioconjugates.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Preclinical Evaluation of 203/212Pb-Labeled Low-Molecular-Weight Compounds for Targeted Radiopharmaceutical Therapy of Prostate Cancer

Sangeeta Ray Banerjee et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

Article Oncology

VCAM-1 targeted alpha-particle therapy for early brain metastases

Aurelien Corroyer-Dulmont et al.

NEURO-ONCOLOGY (2020)

Article Chemistry, Multidisciplinary

Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications

Eduardo Aluicio-Sarduy et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Pb-212 alpha-Radioimmunotherapy Targeting CD38 in Multiple Myeloma: A Preclinical Study

Isabelle Quelven et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Taking cyclotron 68Ga production to the next level: Expeditious solid target production of 68Ga for preparation of radiotracers

Bryce J. B. Nelson et al.

NUCLEAR MEDICINE AND BIOLOGY (2020)

Review Biochemistry & Molecular Biology

203/212Pb Theranostic Radiopharmaceuticals for Image-guided Radionuclide Therapy for Cancer

Mengshi Li et al.

CURRENT MEDICINAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine

Bryce J. B. Nelson et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy

Outi Keinanen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, Research & Experimental

Evaluation of a Novel Pb-203-Labeled Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptide for Melanoma Targeting

Jianquan Yang et al.

MOLECULAR PHARMACEUTICS (2019)

Article Multidisciplinary Sciences

Production and in vivo PET/CT imaging of the theranostic pair 132/135La

Eduardo Aluicio-Sarduy et al.

SCIENTIFIC REPORTS (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Development and dosimetry of 203Pb/212Pb-labelled PSMA ligands: bringing the lead into PSMA-targeted alpha therapy?

Jose Carlos dos Santos et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

Article Biochemistry & Molecular Biology

212Pb-Labeled Antibody 225.28 Targeted to Chondroitin Sulfate Proteoglycan 4 for Triple-Negative Breast Cancer Therapy in Mouse Models

Benjamin B. Kasten et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

212Pb-labeled B7-H3-targeting antibody for pancreatic cancer therapy in mouse models

Benjamin B. Kasten et al.

NUCLEAR MEDICINE AND BIOLOGY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Iodine Symporter Targeting with 124I/131I Theranostics

James Nagarajah et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

B7-H3-targeted 212Pb radioimmunotherapy of ovarian cancer in preclinical models

Benjamin B. Kasten et al.

NUCLEAR MEDICINE AND BIOLOGY (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

Dose Escalation and Dosimetry of First-in-Human α Radioimmunotherapy with 212Pb-TCMC-Trastuzumab

Ruby Meredith et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Editorial Material Medicine, Research & Experimental

Molecular Imaging and Radiotherapy: Theranostics for Personalized Patient Management

Irina Velikyan

THERANOSTICS (2012)

Article Chemistry, Inorganic & Nuclear

The use of radiochromic films to measure and analyze the beam profile of charged particle accelerators

M. A. Avila-Rodriguez et al.

APPLIED RADIATION AND ISOTOPES (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

203Pb-labeled α-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection

Yubin Miao et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

Article Oncology

Melanoma therapy via peptide-targeted α-radiation

YB Miao et al.

CLINICAL CANCER RESEARCH (2005)

Article Radiology, Nuclear Medicine & Medical Imaging

Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes Pb-203 and Pb-212

LL Chappell et al.

NUCLEAR MEDICINE AND BIOLOGY (2000)