Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 120, Issue 31, Pages 7662-7670Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.6b05209
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Funding
- SERB, Department of Science and Technology (DST)
- Council of Scientific and Industrial Research (CSIR), Government of India
- IIT Kharagpur
- CSIR
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In this article, our aim is to investigate the interaction of L-phenylalanine (L-Phe) fibrils with crown ethers (CEs). For this purpose, two different CEs (15-Crown-5 (15C5) and 18-Crown-6 (18C6)) were used. Interestingly, we have observed that both CEs have the ability to arrest fibril formation. However, 18C6 was found to be a better candidate compared to 15C5. Field emission scanning electron microscopy and fluorescence lifetime imaging microscopy were used to monitor the fibril arresting kinetics of CEs. The arresting process was further confirmed by fluorescence correlation spectroscopy and nuclear magnetic resonance studies.
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